Publications by authors named "Jonathan Cheong"

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Comparing the Altis RepliGut Organoid System to MDCK Monolayers in Predicting the Oral Absorption of Lenalidomide.
Cole S Hudson, Jonathan Cheong, Jesse Yu, Eugene C Chen, Laurent Salphati

Pharmaceutics· August 2025

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Transporter expressions as part of required scaling factor to support in vitro in vivo extrapolation for blood-brain barrier drug permeability.
Zubida M Al-Majdoub, Jonathan Cheong, Kunihiko Mizuno, Janita Hogan, Tom De Bruyn

Eur J Pharm Sci· June 2025

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Preclinical assessment of the PI3Kα selective inhibitor inavolisib and prediction of its pharmacokinetics and efficacious dose in human.
Laurent Salphati, Jodie Pang, Emile G Plise, Jonathan Cheong, Marie-Gabrielle Braun

Xenobiotica· October 2024

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Preclinical characterization of the absorption and disposition of the brain penetrant PI3K/mTOR inhibitor paxalisib and prediction of its pharmacokinetics and efficacy in human.
Laurent Salphati, Jodie Pang, Bruno Alicke, Emile G Plise, Jonathan Cheong

Xenobiotica· February 2024

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Effect of magnesium stearate surface coating method on the aerosol performance and permeability of micronized fluticasone propionate.
Virender Kumar, Bharti Sethi, Evelyn Yanez, Dennis H Leung, Yashwardhan Y Ghanwatkar, Jonathan Cheong

Int J Pharm· March 2022

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RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy.
Kyung W Song, Kyle A Edgar, Emily J Hanan, Marc Hafner, Jason Oeh, Jonathan Cheong

Cancer Discov· January 2022

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Improving the Translation of Organic Anion Transporting Polypeptide Substrates using HEK293 Cell Data in the Presence and Absence of Human Plasma via Physiologically Based Pharmacokinetic Modeling.
Christine M Bowman, Buyun Chen, Jonathan Cheong, Liling Liu, Yuan Chen

Drug Metab Dispos· July 2021

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Optimization of globomycin analogs as novel gram-negative antibiotics.
Keira Garland, Homer Pantua, Marie-Gabrielle Braun, Daniel J Burdick, Georgette M Castanedo, Jonathan Cheong

Bioorg Med Chem Lett· October 2020

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Functional similarity of modified cascade impactor to deposit drug particles on cells.
Virender Kumar, Jitender Bariwal, Ajit S Narang, Jerry Tso, Jonathan Cheong

Int J Pharm· June 2020

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Investigating the Impact of Albumin on the Liver Uptake of Pitavastatin and Warfarin in Nagase Analbuminemic Rats.
Jae H Chang, Yi-Chen Chen, Jonathan Cheong, Robert S Jones, Jodie Pang

Drug Metab Dispos· November 2019

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Preclinical assessment of the ADME, efficacy and drug-drug interaction potential of a novel NAMPT inhibitor.
Bianca M Liederer, Jonathan Cheong, Kang-Jye Chou, Peter S Dragovich, Hoa Le

Xenobiotica· September 2019

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Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma.
Sarah M Bronner, Karl A Merrick, Jeremy Murray, Laurent Salphati, John G Moffat, Jonathan Cheong

Bioorg Med Chem Lett· August 2019

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Unremarkable impact of Oatp inhibition on the liver concentration of fluvastatin, lovastatin and pitavastatin in wild-type and Oatp1a/1b knockout mouse.
Jae H Chang, Xiaolin Zhang, Kirsten Messick, Yi-Chen Chen, Eugene Chen, Jonathan Cheong

Xenobiotica· May 2019

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Evaluating the Utility of Canine Mdr1 Knockout Madin-Darby Canine Kidney I Cells in Permeability Screening and Efflux Substrate Determination.
Eugene C Chen, Fabio Broccatelli, Emile Plise, Buyun Chen, Liling Liu, Jonathan Cheong

Mol Pharm· November 2018

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The Effects of Drug Metabolizing Enzyme Inhibitors on Hepatic Efflux and Uptake Transporters.
Jonathan Cheong, Jason S Halladay, Emile Plise, Jasleen K Sodhi, Laurent Salphati

Drug Metab Lett· October 2018

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Brain Distribution and Efficacy of the Brain Penetrant PI3K Inhibitor GDC-0084 in Orthotopic Mouse Models of Human Glioblastoma.
Laurent Salphati, Bruno Alicke, Timothy P Heffron, Sheerin Shahidi-Latham, Merry Nishimura, Jonathan Cheong

Drug Metab Dispos· December 2016

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Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR.
Timothy P Heffron, Chudi O Ndubaku, Laurent Salphati, Bruno Alicke, Jonathan Cheong

ACS Med Chem Lett· April 2016

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Novel antibody-antibiotic conjugate eliminates intracellular S. aureus.
Sophie M Lehar, Thomas Pillow, Min Xu, Leanna Staben, Kimberly K Kajihara, Jonathan Cheong

Nature· November 2015

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Practical permeability-based hepatic clearance classification system (HepCCS) in drug discovery.
Peter W Fan, Yang Song, Leonid M Berezhkovskiy, Jonathan Cheong, Emile G Plise

Future Med Chem· September 2015

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Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors.
James J Crawford, Wendy Lee, Ignacio Aliagas, Simon Mathieu, Klaus P Hoeflich, Jonathan Cheong

J Med Chem· June 2015

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Differential effects of Rifampin and Ketoconazole on the blood and liver concentration of atorvastatin in wild-type and Cyp3a and Oatp1a/b knockout mice.
Jae H Chang, Justin Ly, Emile Plise, Xiaolin Zhang, Kirsten Messick, Jonathan Cheong

Drug Metab Dispos· June 2014

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Use of cassette dosing approach to examine the effects of P-glycoprotein on the brain and cerebrospinal fluid concentrations in wild-type and P-glycoprotein knockout rats.
Xingrong Liu, Jonathan Cheong, Xiao Ding, Gauri Deshmukh

Drug Metab Dispos· April 2014

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Evaluating the in vitro inhibition of UGT1A1, OATP1B1, OATP1B3, MRP2, and BSEP in predicting drug-induced hyperbilirubinemia.
Jae H Chang, Emile Plise, Jonathan Cheong, Quynh Ho, Molly Lin

Mol Pharm· August 2013

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Targeting the PI3K pathway in the brain--efficacy of a PI3K inhibitor optimized to cross the blood-brain barrier.
Laurent Salphati, Timothy P Heffron, Bruno Alicke, Merry Nishimura, Kai Barck, Jonathan Cheong

Clin Cancer Res· November 2012

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The design and identification of brain penetrant inhibitors of phosphoinositide 3-kinase α.
Timothy P Heffron, Laurent Salphati, Bruno Alicke, Jonathan Cheong, Jennafer Dotson

J Med Chem· September 2012

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