Publications by authors named "Jonathan D Geiger"

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Involvement of endolysosome iron in HIV-1 gp120-, morphine-, and iron supplementation-induced disruption of the reactive species interactome and induction of neurotoxicity.
Nirmal Kumar, Peter W Halcrow, Darius N K Quansah, Braelyn Liang, Olimpia Meucci, Jonathan D Geiger

Redox Rep· December 2025

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Involvement of Endolysosomes and Aurora Kinase A in the Regulation of Amyloid β Protein Levels in Neurons.
Zahra Afghah, Nabab Khan, Gaurav Datta, Peter W Halcrow, Jonathan D Geiger

Int J Mol Sci· June 2024

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HERV-K (HML-2) Envelope Protein Induces Mitochondrial Depolarization and Neurotoxicity via Endolysosome Iron Dyshomeostasis.
Peter W Halcrow, Darius N K Quansah, Nirmal Kumar, Joseph P Steiner, Avindra Nath, Jonathan D Geiger

J Neurosci· April 2024

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Weak base drug-induced endolysosome iron dyshomeostasis controls the generation of reactive oxygen species, mitochondrial depolarization, and cytotoxicity.
Peter W Halcrow, Darius N K Quansah, Nirmal Kumar, Rebecca L Solloway, Kayla M Teigen, Jonathan D Geiger

NeuroImmune Pharm Ther· March 2024

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Mu opioid receptor-mediated release of endolysosome iron increases levels of mitochondrial iron, reactive oxygen species, and cell death.
Peter W Halcrow, Nirmal Kumar, Emily Hao, Nabab Khan, Olimpia Meucci, Jonathan D Geiger

NeuroImmune Pharm Ther· March 2023

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Correction: Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease.
Xuesong Chen, Jeremy W Gawryluk, John F Wagener, Othman Ghribi, Jonathan D Geiger

J Neuroinflammation· February 2023

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HIV-1 gp120-Induced Endolysosome de-Acidification Leads to Efflux of Endolysosome Iron, and Increases in Mitochondrial Iron and Reactive Oxygen Species.
Peter W Halcrow, Koffi L Lakpa, Nabab Khan, Zahra Afghah, Nicole Miller, Jonathan D Geiger

J Neuroimmune Pharmacol· June 2022

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Dimethoxycurcumin Acidifies Endolysosomes and Inhibits SARS-CoV-2 Entry.
Nabab Khan, Zahra Afghah, Aparajita Baral, Jonathan D Geiger, Xuesong Chen

Front Virol· June 2022

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Endolysosome Iron Chelation Inhibits HIV-1 Protein-Induced Endolysosome De-Acidification-Induced Increases in Mitochondrial Fragmentation, Mitophagy, and Cell Death.
Peter W Halcrow, Nirmal Kumar, Darius N K Quansah, Aparajita Baral, Braelyn Liang, Jonathan D Geiger

Cells· May 2022

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Heterogeneity of ferrous iron-containing endolysosomes and effects of endolysosome iron on endolysosome numbers, sizes, and localization patterns.
Peter W Halcrow, Nirmal Kumar, Zahra Afghah, Jalyn P Fischer, Nabab Khan, Jonathan D Geiger

J Neurochem· April 2022

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HIV-1 Tat endocytosis and retention in endolysosomes affects HIV-1 Tat-induced LTR transactivation in astrocytes.
Nabab Khan, Peter W Halcrow, Zahra Afghah, Aparajita Baral, Jonathan D Geiger

FASEB J· March 2022

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The impact of methodology on the reproducibility and rigor of DNA methylation data.
Detlev Boison, Susan A Masino, Farah D Lubin, Kai Guo, Theresa Lusardi, Jonathan D Geiger

Sci Rep· January 2022

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A common approach for fighting tuberculosis and leprosy: controlling endoplasmic reticulum stress in myeloid-derived suppressor cells.
Nirmal Kumar, Nabab Khan, Dawn Cleveland, Jonathan D Geiger

Immunotherapy· December 2021

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Endolysosome Localization of ERα Is Involved in the Protective Effect of 17α-Estradiol against HIV-1 gp120-Induced Neuronal Injury.
Gaurav Datta, Nicole M Miller, Wenjuan Du, Jonathan D Geiger, Sulie Chang

J Neurosci· December 2021

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Role of endolysosome function in iron metabolism and brain carcinogenesis.
Peter W Halcrow, Miranda L Lynch, Jonathan D Geiger, Joyce E Ohm

Semin Cancer Biol· November 2021

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Endolysosome iron restricts Tat-mediated HIV-1 LTR transactivation by increasing HIV-1 Tat oligomerization and β-catenin expression.
Nabab Khan, Peter W Halcrow, Leo K Lakpa, Mohd Rehan, Xuesong Chen, Jonathan D Geiger

J Neurovirol· October 2021

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SARS-CoV-2 S1 Protein Induces Endolysosome Dysfunction and Neuritic Dystrophy.
Gaurav Datta, Nicole M Miller, Peter W Halcrow, Nabab Khan, Timothy Colwell, Jonathan D Geiger

Front Cell Neurosci· October 2021

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Role of Viral Protein U (Vpu) in HIV-1 Infection and Pathogenesis.
Nabab Khan, Jonathan D Geiger

Viruses· July 2021

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Lysosomal Stress Response (LSR): Physiological Importance and Pathological Relevance.
Koffi L Lakpa, Nabab Khan, Zahra Afghah, Xuesong Chen, Jonathan D Geiger

J Neuroimmune Pharmacol· June 2021

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Overcoming Chemoresistance: Altering pH of Cellular Compartments by Chloroquine and Hydroxychloroquine.
Peter W Halcrow, Jonathan D Geiger, Xuesong Chen

Front Cell Dev Biol· February 2021

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Possible therapeutic targets for SARS-CoV-2 infection and COVID-19.
Nabab Khan, Nirmal Kumar, Jonathan D Geiger

J Allergy Infect Dis· January 2021

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Possible Therapeutic Use of Natural Compounds Against COVID-19.
Nabab Khan, Xuesong Chen, Jonathan D Geiger

J Cell Signal· January 2021

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Possible Role of Adenosine in COVID-19 Pathogenesis and Therapeutic Opportunities.
Jonathan D Geiger, Nabab Khan, Madhuvika Murugan, Detlev Boison

Front Pharmacol· November 2020

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Role of Endolysosomes in Severe Acute Respiratory Syndrome Coronavirus-2 Infection and Coronavirus Disease 2019 Pathogenesis: Implications for Potential Treatments.
Nabab Khan, Xuesong Chen, Jonathan D Geiger

Front Pharmacol· October 2020

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Janus sword actions of chloroquine and hydroxychloroquine against COVID-19.
Xuesong Chen, Jonathan D Geiger

Cell Signal· September 2020

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