Publications by authors named "Jonathan Gilley"

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Chronically Low NMNAT2 Expression Causes Sub-lethal SARM1 Activation and Altered Response to Nicotinamide Riboside in Axons.
Christina Antoniou, Andrea Loreto, Jonathan Gilley, Elisa Merlini, Giuseppe Orsomando

Mol Neurobiol· March 2025

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Author Correction: NMNAT2 is a druggable target to drive neuronal NAD production.
James R Tribble, Melissa Jöe, Carmine Varricchio, Amin Otmani, Alessio Canovai, Jonathan Gilley

Nat Commun· September 2024

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NMNAT2 is a druggable target to drive neuronal NAD production.
James R Tribble, Melissa Jöe, Carmine Varricchio, Amin Otmani, Alessio Canovai, Jonathan Gilley

Nat Commun· July 2024

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Adaptation of a Commercial NAD Quantification Kit to Assay the Base-Exchange Activity and Substrate Preferences of SARM1.
Ilenia Cirilli, Adolfo Amici, Jonathan Gilley, Michael P Coleman, Giuseppe Orsomando

Molecules· February 2024

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NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport.
Sen Yang, Zhen-Xian Niou, Andrea Enriquez, Jacob LaMar, Jui-Yen Huang, Jonathan Gilley

Mol Neurodegener· January 2024

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NMN: The NAD precursor at the intersection between axon degeneration and anti-ageing therapies.
Andrea Loreto, Christina Antoniou, Elisa Merlini, Jonathan Gilley, Michael P Coleman

Neurosci Res· December 2023

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NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport.
Sen Yang, Zhen-Xian Niou, Andrea Enriquez, Jacob LaMar, Jui-Yen Huang, Jonathan Gilley

Res Sq· May 2023

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The NAD precursor NMN activates dSarm to trigger axon degeneration in .
Arnau Llobet Rosell, Maria Paglione, Jonathan Gilley, Magdalena Kocia, Giulia Perillo

Elife· December 2022

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Natural variants of human SARM1 cause both intrinsic and dominant loss-of-function influencing axon survival.
Mirlinda Ademi, Xiuna Yang, Michael P Coleman, Jonathan Gilley

Sci Rep· August 2022

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SARM1 is a multi-functional NAD(P)ase with prominent base exchange activity, all regulated bymultiple physiologically relevant NAD metabolites.
Carlo Angeletti, Adolfo Amici, Jonathan Gilley, Andrea Loreto, Antonio G Trapanotto

iScience· February 2022

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Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1.
Andrea Loreto, Carlo Angeletti, Weixi Gu, Andrew Osborne, Bart Nieuwenhuis, Jonathan Gilley

Elife· December 2021

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Sarm1 haploinsufficiency or low expression levels after antisense oligonucleotides delay programmed axon degeneration.
Stacey Anne Gould, Jonathan Gilley, Karen Ling, Paymaan Jafar-Nejad, Frank Rigo

Cell Rep· December 2021

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Enrichment of alleles encoding variants with constitutively hyperactive NADase in patients with ALS and other motor nerve disorders.
Jonathan Gilley, Oscar Jackson, Menelaos Pipis, Mehrdad A Estiar, Ammar Al-Chalabi

Elife· November 2021

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Axon Degeneration Assays in Superior Cervical Ganglion Explant Cultures.
Andrea Loreto, Jonathan Gilley

Methods Mol Biol· March 2021

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Microinjection of Superior Cervical Ganglion Neurons for Studying Axon Degeneration.
Jonathan Gilley, Andrea Loreto

Methods Mol Biol· March 2021

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Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration.
Andrea Loreto, Ciaran S Hill, Victoria L Hewitt, Giuseppe Orsomando, Carlo Angeletti, Jonathan Gilley

Neurobiol Dis· February 2020

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Novel HDAC6 Inhibitors Increase Tubulin Acetylation and Rescue Axonal Transport of Mitochondria in a Model of Charcot-Marie-Tooth Type 2F.
Robert Adalbert, Akira Kaieda, Christina Antoniou, Andrea Loreto, Xiuna Yang, Jonathan Gilley

ACS Chem Neurosci· February 2020

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Homozygous NMNAT2 mutation in sisters with polyneuropathy and erythromelalgia.
Peter Huppke, Eike Wegener, Jonathan Gilley, Carlo Angeletti, Ingo Kurth

Exp Neurol· October 2019

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Severe biallelic loss-of-function mutations in nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) in two fetuses with fetal akinesia deformation sequence.
Marshall Lukacs, Jonathan Gilley, Yi Zhu, Giuseppe Orsomando, Carlo Angeletti

Exp Neurol· October 2019

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NAD cleavage activity by animal and plant TIR domains in cell death pathways.
Shane Horsefield, Hayden Burdett, Xiaoxiao Zhang, Mohammad K Manik, Yun Shi, Jonathan Gilley

Science· August 2019

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Low levels of NMNAT2 compromise axon development and survival.
Jonathan Gilley, Paul R Mayer, Gang Yu, Michael P Coleman

Hum Mol Genet· February 2019

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Sarm1 Deletion, but Not Wld, Confers Lifelong Rescue in a Mouse Model of Severe Axonopathy.
Jonathan Gilley, Richard R Ribchester, Michael P Coleman

Cell Rep· October 2017

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NMN Deamidase Delays Wallerian Degeneration and Rescues Axonal Defects Caused by NMNAT2 Deficiency In Vivo.
Michele Di Stefano, Andrea Loreto, Giuseppe Orsomando, Valerio Mori, Federica Zamporlini, Jonathan Gilley

Curr Biol· March 2017

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Application of virtual screening to the discovery of novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with potential for the treatment of cancer and axonopathies.
David E Clark, Bohdan Waszkowycz, Melanie Wong, Peter M Lockey, Robert Adalbert, Jonathan Gilley

Bioorg Med Chem Lett· June 2016

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Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice.
Jonathan Gilley, Kunie Ando, Anjan Seereeram, Teresa Rodríguez-Martín, Amy M Pooler

Neurobiol Aging· March 2016

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