Publications by authors named "Jonathan J Lyon"

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DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc.
Stéphanie Braillard, Martine Keenan, Karen J Breese, Jacob Heppell, Michael Abbott, Jonathan J Lyon

Sci Transl Med· December 2023

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The generation of HepG2 transmitochondrial cybrids to reveal the role of mitochondrial genotype in idiosyncratic drug-induced liver injury.
Amy Louise Ball, Carol E Jolly, Mark G Lennon, Jonathan J Lyon, Ana Alfirevic

Elife· June 2023

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Time to Change: A Systems Pharmacology Approach to Disentangle Mechanisms of Drug-Induced Mitochondrial Toxicity.
Charlotte A Hoogstraten, Jonathan J Lyon, Jan A M Smeitink, Frans G M Russel, Tom J J Schirris

Pharmacol Rev· May 2023

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Enhanced hepatic respiratory capacity and altered lipid metabolism support metabolic homeostasis during short-term hypoxic stress.
Katie A O'Brien, Ben D McNally, Alice P Sowton, Antonio Murgia, James Armitage, Jonathan J Lyon

BMC Biol· December 2021

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Assessment of the impact of mitochondrial genotype upon drug-induced mitochondrial dysfunction in platelets derived from healthy volunteers.
Amy L Ball, Katarzyna M Bloch, Lucille Rainbow, Xuan Liu, John Kenny, Jonathan J Lyon

Arch Toxicol· April 2021

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Identification of the Additional Mitochondrial Liabilities of 2-Hydroxyflutamide When Compared With its Parent Compound, Flutamide in HepG2 Cells.
Amy L Ball, Laleh Kamalian, Ana Alfirevic, Jonathan J Lyon, Amy E Chadwick

Toxicol Sci· October 2016

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Effects of mid-respiratory chain inhibition on mitochondrial function and .
Ashley J Broom, Jeffrey Ambroso, Gino Brunori, Angie K Burns, James R Armitage, Jonathan J Lyon

Toxicol Res (Camb)· January 2016

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Doxorubicin in vivo rapidly alters expression and translation of myocardial electron transport chain genes, leads to ATP loss and caspase 3 activation.
Amy V Pointon, Tracy M Walker, Kate M Phillips, Jinli Luo, Joan Riley, Jonathan J Lyon

PLoS One· September 2010

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Pivotal role for two electron reduction in 2,3-dimethoxy-1,4-naphthoquinone and 2-methyl-1,4-naphthoquinone metabolism and kinetics in vivo that prevents liver redox stress.
Joel D Parry, Amy V Pointon, Ursula Lutz, Friederike Teichert, Joanne K Charlwood, Jonathan J Lyon

Chem Res Toxicol· April 2009

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