Publications by authors named "Jonathan Maybaum"

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The contribution of DNA replication stress marked by high-intensity, pan-nuclear γH2AX staining to chemosensitization by CHK1 and WEE1 inhibitors.
Leslie A Parsels, Joshua D Parsels, Daria M Tanska, Jonathan Maybaum, Theodore S Lawrence

Cell Cycle· December 2019

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Dose Escalation Trial of the Wee1 Inhibitor Adavosertib (AZD1775) in Combination With Gemcitabine and Radiation for Patients With Locally Advanced Pancreatic Cancer.
Kyle C Cuneo, Meredith A Morgan, Vaibhav Sahai, Matthew J Schipper, Leslie A Parsels, Jonathan Maybaum

J Clin Oncol· October 2019

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PARP1 Trapping and DNA Replication Stress Enhance Radiosensitization with Combined WEE1 and PARP Inhibitors.
Leslie A Parsels, David Karnak, Joshua D Parsels, Qiang Zhang, Jonathan Vélez-Padilla, Jonathan Maybaum

Mol Cancer Res· February 2018

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Dissociation of gemcitabine chemosensitization by CHK1 inhibition from cell cycle checkpoint abrogation and aberrant mitotic entry.
Leslie A Parsels, Daria M Tanska, Joshua D Parsels, Sonya D Zabludoff, Kyle C Cuneo, Jonathan Maybaum

Cell Cycle· December 2016

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Wee1 Kinase Inhibitor AZD1775 Radiosensitizes Hepatocellular Carcinoma Regardless of TP53 Mutational Status Through Induction of Replication Stress.
Kyle C Cuneo, Meredith A Morgan, Mary A Davis, Leslie A Parcels, Joshua Parcels, Jonathan Maybaum

Int J Radiat Oncol Biol Phys· June 2016

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Sensitization of Pancreatic Cancers to Gemcitabine Chemoradiation by WEE1 Kinase Inhibition Depends on Homologous Recombination Repair.
Tasneem Kausar, Jason S Schreiber, David Karnak, Leslie A Parsels, Joshua D Parsels, Jonathan Maybaum

Neoplasia· October 2015

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Combined inhibition of Wee1 and PARP1/2 for radiosensitization in pancreatic cancer.
David Karnak, Carl G Engelke, Leslie A Parsels, Tasneem Kausar, Dongping Wei, Jonathan Maybaum

Clin Cancer Res· October 2014

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Improving the efficacy of chemoradiation with targeted agents.
Meredith A Morgan, Leslie A Parsels, Jonathan Maybaum, Theodore S Lawrence

Cancer Discov· March 2014

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Inhibition of protein phosphatase 2A radiosensitizes pancreatic cancers by modulating CDC25C/CDK1 and homologous recombination repair.
Dongping Wei, Leslie A Parsels, David Karnak, Mary A Davis, Joshua D Parsels, Jonathan Maybaum

Clin Cancer Res· August 2013

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Sensitization of pancreatic cancer to chemoradiation by the Chk1 inhibitor MK8776.
Carl G Engelke, Leslie A Parsels, Yushen Qian, Qiang Zhang, David Karnak, Jonathan Maybaum

Clin Cancer Res· August 2013

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Sensitization of pancreatic cancer stem cells to gemcitabine by Chk1 inhibition.
Venkatasubbaiah A Venkatesha, Leslie A Parsels, Joshua D Parsels, Lili Zhao, Sonya D Zabludoff, Jonathan Maybaum

Neoplasia· June 2012

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Selective radiosensitization of p53 mutant pancreatic cancer cells by combined inhibition of Chk1 and PARP1.
Sean Vance, Erqi Liu, Lili Zhao, Joshua D Parsels, Leslie A Parsels, Jonathan Maybaum

Cell Cycle· December 2011

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Assessment of chk1 phosphorylation as a pharmacodynamic biomarker of chk1 inhibition.
Leslie A Parsels, Yushen Qian, Daria M Tanska, Marisa Gross, Lili Zhao, Jonathan Maybaum

Clin Cancer Res· June 2011

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Bayesian hierarchical changepoint methods in modeling the tumor growth profiles in xenograft experiments.
Lili Zhao, Meredith A Morgan, Leslie A Parsels, Jonathan Maybaum, Theodore S Lawrence

Clin Cancer Res· March 2011

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Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.
Meredith A Morgan, Leslie A Parsels, Lili Zhao, Joshua D Parsels, Mary A Davis, Jonathan Maybaum

Cancer Res· June 2010

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Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells.
Leslie A Parsels, Meredith A Morgan, Daria M Tanska, Joshua D Parsels, Brian D Palmer, Jonathan Maybaum

Mol Cancer Ther· January 2009

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Improving gemcitabine-mediated radiosensitization using molecularly targeted therapy: a review.
Meredith A Morgan, Leslie A Parsels, Jonathan Maybaum, Theodore S Lawrence

Clin Cancer Res· November 2008

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The combination of epidermal growth factor receptor inhibitors with gemcitabine and radiation in pancreatic cancer.
Meredith A Morgan, Leslie A Parsels, Laura E Kollar, Daniel P Normolle, Jonathan Maybaum

Clin Cancer Res· August 2008

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The relationship of premature mitosis to cytotoxicity in response to checkpoint abrogation and antimetabolite treatment.
Meredith A Morgan, Leslie A Parsels, Joshua D Parsels, Theodore S Lawrence, Jonathan Maybaum

Cell Cycle· September 2006

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Role of checkpoint kinase 1 in preventing premature mitosis in response to gemcitabine.
Meredith A Morgan, Leslie A Parsels, Joshua D Parsels, Alefiyah K Mesiwala, Jonathan Maybaum

Cancer Res· August 2005

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5-fluoro-2'-deoxyuridine-induced cdc25A accumulation correlates with premature mitotic entry and clonogenic death in human colon cancer cells.
Leslie Anne Parsels, Joshua David Parsels, Daniel Chung-Ho Tai, Daniel James Coughlin, Jonathan Maybaum

Cancer Res· September 2004

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Effects of dexamethasone or celecoxib on biliary toxicity after hepatic arterial infusion of 5-fluorodeoxyuridine in a canine model.
William Ensminger, James Knol, Susan DeRemer, Erby Wilkinson, Suzette Walker, Jonathan Maybaum

Cancer Res· January 2004

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