Publications by authors named "Joshua D Parsels"

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H3K27M diffuse midline glioma is homologous recombination defective and sensitized to radiotherapy and NK cell-mediated antitumor immunity by PARP inhibition.
Yupei Guo, Zian Li, Leslie A Parsels, Zhuwen Wang, Joshua D Parsels

Neuro Oncol· September 2025

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Olaparib and Radiotherapy Induce Type I Interferon- and CD8+ T Cell-Dependent Sensitization to Immunotherapy in Pancreatic Cancer.
Victoria M Valvo, Qiang Zhang, Long Jiang, Erin A Holcomb, Ashley N Pearson, Leslie A Parsels, Joshua D Parsels

Mol Cancer Ther· June 2025

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H3K27M diffuse midline glioma is homologous recombination defective and sensitized to radiotherapy and NK cell-mediated antitumor immunity by PARP inhibition.
Yupei Guo, Zian Li, Leslie A Parsels, Zhuwen Wang, Joshua D Parsels

bioRxiv· August 2024

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Potentiating the radiation-induced type I interferon antitumoral immune response by ATM inhibition in pancreatic cancer.
Qiang Zhang, Long Jiang, Weiwei Wang, Amanda K Huber, Victoria M Valvo, Leslie A Parsels, Joshua D Parsels

JCI Insight· February 2024

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DNA-PK Inhibition and Radiation Promote Antitumoral Immunity through RNA Polymerase III in Pancreatic Cancer.
Weiwei Wang, Matthew T McMillan, Xinyi Zhao, Zhuwen Wang, Long Jiang, Joshua D Parsels, Leslie A Parsels

Mol Cancer Res· July 2022

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Translation of DNA Damage Response Inhibitors as Chemoradiation Sensitizers From the Laboratory to the Clinic.
Leslie A Parsels, Qiang Zhang, David Karnak, Joshua D Parsels, Kwok Lam

Int J Radiat Oncol Biol Phys· December 2021

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Cytidine Deaminase APOBEC3A Regulates PD-L1 Expression in Cancer Cells in a JNK/c-JUN-Dependent Manner.
Kailiang Zhao, Qiang Zhang, Sheryl A Flanagan, Xueting Lang, Long Jiang, Leslie A Parsels, Joshua D Parsels

Mol Cancer Res· September 2021

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The contribution of DNA replication stress marked by high-intensity, pan-nuclear γH2AX staining to chemosensitization by CHK1 and WEE1 inhibitors.
Leslie A Parsels, Joshua D Parsels, Daria M Tanska, Jonathan Maybaum, Theodore S Lawrence

Cell Cycle· December 2019

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Dose Escalation Trial of the Wee1 Inhibitor Adavosertib (AZD1775) in Combination With Gemcitabine and Radiation for Patients With Locally Advanced Pancreatic Cancer.
Kyle C Cuneo, Meredith A Morgan, Vaibhav Sahai, Matthew J Schipper, Leslie A Parsels, Joshua D Parsels

J Clin Oncol· October 2019

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Inhibition of ATM Increases Interferon Signaling and Sensitizes Pancreatic Cancer to Immune Checkpoint Blockade Therapy.
Qiang Zhang, Michael D Green, Xueting Lang, Jenny Lazarus, Joshua D Parsels, Leslie A Parsels

Cancer Res· August 2019

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PARP1 Trapping and DNA Replication Stress Enhance Radiosensitization with Combined WEE1 and PARP Inhibitors.
Leslie A Parsels, David Karnak, Joshua D Parsels, Qiang Zhang, Jonathan Vélez-Padilla

Mol Cancer Res· February 2018

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Glioblastoma Therapy Can Be Augmented by Targeting IDH1-Mediated NADPH Biosynthesis.
Daniel R Wahl, Joseph Dresser, Kari Wilder-Romans, Joshua D Parsels, Shuang G Zhao

Cancer Res· February 2017

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Dissociation of gemcitabine chemosensitization by CHK1 inhibition from cell cycle checkpoint abrogation and aberrant mitotic entry.
Leslie A Parsels, Daria M Tanska, Joshua D Parsels, Sonya D Zabludoff, Kyle C Cuneo

Cell Cycle· December 2016

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Fbxw7 Deletion Accelerates Kras-Driven Pancreatic Tumorigenesis via Yap Accumulation.
Qiang Zhang, Yaqing Zhang, Joshua D Parsels, Ines Lohse, Theodore S Lawrence

Neoplasia· November 2016

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Sensitization of Pancreatic Cancers to Gemcitabine Chemoradiation by WEE1 Kinase Inhibition Depends on Homologous Recombination Repair.
Tasneem Kausar, Jason S Schreiber, David Karnak, Leslie A Parsels, Joshua D Parsels

Neoplasia· October 2015

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Inhibition of protein phosphatase 2A radiosensitizes pancreatic cancers by modulating CDC25C/CDK1 and homologous recombination repair.
Dongping Wei, Leslie A Parsels, David Karnak, Mary A Davis, Joshua D Parsels

Clin Cancer Res· August 2013

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Sensitization of pancreatic cancer to chemoradiation by the Chk1 inhibitor MK8776.
Carl G Engelke, Leslie A Parsels, Yushen Qian, Qiang Zhang, David Karnak, Joshua D Parsels

Clin Cancer Res· August 2013

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Sensitization of pancreatic cancer stem cells to gemcitabine by Chk1 inhibition.
Venkatasubbaiah A Venkatesha, Leslie A Parsels, Joshua D Parsels, Lili Zhao, Sonya D Zabludoff

Neoplasia· June 2012

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Selective radiosensitization of p53 mutant pancreatic cancer cells by combined inhibition of Chk1 and PARP1.
Sean Vance, Erqi Liu, Lili Zhao, Joshua D Parsels, Leslie A Parsels

Cell Cycle· December 2011

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Assessment of chk1 phosphorylation as a pharmacodynamic biomarker of chk1 inhibition.
Leslie A Parsels, Yushen Qian, Daria M Tanska, Marisa Gross, Lili Zhao, Joshua D Parsels

Clin Cancer Res· June 2011

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Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.
Meredith A Morgan, Leslie A Parsels, Lili Zhao, Joshua D Parsels, Mary A Davis

Cancer Res· June 2010

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Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells.
Leslie A Parsels, Meredith A Morgan, Daria M Tanska, Joshua D Parsels, Brian D Palmer

Mol Cancer Ther· January 2009

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The relationship of premature mitosis to cytotoxicity in response to checkpoint abrogation and antimetabolite treatment.
Meredith A Morgan, Leslie A Parsels, Joshua D Parsels, Theodore S Lawrence, Jonathan Maybaum

Cell Cycle· September 2006

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Role of checkpoint kinase 1 in preventing premature mitosis in response to gemcitabine.
Meredith A Morgan, Leslie A Parsels, Joshua D Parsels, Alefiyah K Mesiwala, Jonathan Maybaum

Cancer Res· August 2005

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5-fluoro-2'-deoxyuridine-induced cdc25A accumulation correlates with premature mitotic entry and clonogenic death in human colon cancer cells.
Leslie Anne Parsels, Joshua David Parsels, Daniel Chung-Ho Tai, Daniel James Coughlin, Jonathan Maybaum

Cancer Res· September 2004

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