Publications by authors named "Jonathan Moggs"

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Innovative Medicines Initiative public-private partnerships to enhance translational safety.
Salah-Dine Chibout, Dominique Brees, Magda Chlebus, Philippe Detilleux, Loic Laplanche, Jonathan Moggs

Nat Rev Drug Discov· October 2025

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Novel strategies to assess cytokine release mediated by chimeric antigen receptor T cells based on the adverse outcome pathway concept.
Miriam Alb, Kristin Reiche, Michael Rade, Katherina Sewald, Peter Loskill, Jonathan Moggs

J Immunotoxicol· October 2024

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Unaltered hepatic wound healing response in male rats with ancestral liver injury.
Johanna Beil, Juliane Perner, Lena Pfaller, Marie-Apolline Gérard, Alessandro Piaia, Jonathan Moggs

Nat Commun· October 2023

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Using human genetics to improve safety assessment of therapeutics.
Keren J Carss, Aimee M Deaton, Alberto Del Rio-Espinola, Dorothée Diogo, Mark Fielden, Jonathan Moggs

Nat Rev Drug Discov· February 2023

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Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies.
Ying Huang, Martin Sendzik, Jeff Zhang, Zhenting Gao, Yongfeng Sun, Jonathan Moggs

J Med Chem· April 2022

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Correction: The genetic consequences of dog breed formation-Accumulation of deleterious genetic variation and fixation of mutations associated with myxomatous mitral valve disease in cavalier King Charles spaniels.
Erik Axelsson, Ingrid Ljungvall, Priyasma Bhoumik, Laura Bas Conn, Eva Muren, Jonathan Moggs

PLoS Genet· January 2022

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The genetic consequences of dog breed formation-Accumulation of deleterious genetic variation and fixation of mutations associated with myxomatous mitral valve disease in cavalier King Charles spaniels.
Erik Axelsson, Ingrid Ljungvall, Priyasma Bhoumik, Laura Bas Conn, Eva Muren, Jonathan Moggs

PLoS Genet· September 2021

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Outcomes of the European Federation of Pharmaceutical Industries and Associations Oligonucleotide Working Group Survey on Nonclinical Practices and Regulatory Expectations for Therapeutic Oligonucleotide Safety Assessment.
Yann Tessier, William Achanzar, Lauren Mihalcik, Chidozie Amuzie, Patrik Andersson, Jonathan Moggs

Nucleic Acid Ther· February 2021

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Nonclinical safety assessment of epigenetic modulatory drugs: Current status and industry perspective.
Vincent L Reynolds, Paul Butler, Matthew M Abernathy, Laura Aschenbrenner, Derek D Best, Jonathan Moggs

Regul Toxicol Pharmacol· November 2020

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A cross-sector call to improve carcinogenicity risk assessment through use of genomic methodologies.
Carole L Yauk, Alison H Harrill, Heidrun Ellinger-Ziegelbauer, Jan Willem van der Laan, Jonathan Moggs

Regul Toxicol Pharmacol· February 2020

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Drug-induced chromatin accessibility changes associate with sensitivity to liver tumor promotion.
Antonio Vitobello, Juliane Perner, Johanna Beil, Jiang Zhu, Alberto Del Río-Espínola, Jonathan Moggs

Life Sci Alliance· October 2019

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Constitutive androstane receptor 1 is constitutively bound to chromatin and 'primed' for transactivation in hepatocytes.
Michael McMahon, Shaohong Ding, Lourdes Acosta Jimenez, Remi Terranova, Marie-Apolline Gerard, Jonathan Moggs

Mol Pharmacol· January 2019

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Chromatin dynamics underlying latent responses to xenobiotics.
Jonathan Moggs, Rémi Terranova

Toxicol Res (Camb)· July 2018

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Human relevance of rodent liver tumors: Key insights from a Toxicology Forum workshop on nongenotoxic modes of action.
Susan P Felter, Jennifer E Foreman, Alan Boobis, J Christopher Corton, Adriana M Doi, Jonathan Moggs

Regul Toxicol Pharmacol· February 2018

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Defining baseline epigenetic landscapes in the rat liver.
John P Thomson, Raffaele Ottaviano, Roland Buesen, Jonathan G Moggs, Michael Schwarz

Epigenomics· December 2017

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Xenobiotic CAR Activators Induce Dlk1-Dio3 Locus Noncoding RNA Expression in Mouse Liver.
Lucie Pouché, Antonio Vitobello, Michael Römer, Milica Glogovac, A Kenneth MacLeod, Jonathan G Moggs

Toxicol Sci· August 2017

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A Synopsis of the "Influence of Epigenetics, Genetics, and Immunology" Session Part A at the 35th Annual Society of Toxicologic Pathology Symposium.
Alison H Harrill, Jonathan G Moggs, Karissa K Adkins, Hellmut G Augustin, Robert C Johnson

Toxicol Pathol· January 2017

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Translational Safety Genetics.
Priyasma Bhoumik, Alberto Del Rio-Espinola, Florian Hahne, Jonathan Moggs, Olivier Grenet

Toxicol Pathol· January 2017

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Derisking Drug-Induced Carcinogenicity for Novel Therapeutics.
Jonathan G Moggs, Timothy MacLachlan, Hans-Joerg Martus, Philip Bentley

Trends Cancer· August 2016

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Loss of Tet1-Associated 5-Hydroxymethylcytosine Is Concomitant with Aberrant Promoter Hypermethylation in Liver Cancer.
John P Thomson, Raffaele Ottaviano, Elif B Unterberger, Harri Lempiäinen, Arne Muller, Jonathan G Moggs

Cancer Res· May 2016

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Reciprocal changes in DNA methylation and hydroxymethylation and a broad repressive epigenetic switch characterize FMR1 transcriptional silencing in fragile X syndrome.
Sarah Brasa, Arne Mueller, Sébastien Jacquemont, Florian Hahne, Izabela Rozenberg, Jonathan Moggs

Clin Epigenetics· April 2016

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Evaluation of 5-methylcytosine and 5-hydroxymethylcytosine as potential biomarkers for characterisation of chemical allergens.
Victoria L Chapman, Rémi Terranova, Jonathan G Moggs, Ian Kimber, Rebecca J Dearman

Toxicology· January 2016

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Importance of investigating epigenetic alterations for industry and regulators: An appraisal of current efforts by the Health and Environmental Sciences Institute.
Isabelle R Miousse, Richard Currie, Kaushik Datta, Heidrun Ellinger-Ziegelbauer, John E French, Jonathan G Moggs

Toxicology· September 2015

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Chemical allergen induced perturbations of the mouse lymph node DNA methylome.
Victoria Louise Chapman, Tulipan Zollinger, Rémi Terranova, Jonathan Moggs, Ian Kimber

Toxicol Sci· June 2014

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Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors.
Raphaëlle Luisier, Harri Lempiäinen, Nina Scherbichler, Albert Braeuning, Miriam Geissler, Jonathan G Moggs

Toxicol Sci· June 2014

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