Publications by authors named "Dominique Brees"

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Impact of pre-existing immunity on safety and biodistribution of a single AAV9 vectorintrathecal injection in cynomolgus monkeys.
Maria Vono, Tony Del Rio, Eduardo Magdaleno, Nathalie R Loll, Philip Jarvis, Dominique Brees

Mol Ther Methods Clin Dev· December 2025

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Assessment of antigen-specific T cell recall responses in non-human primates using a composite AIM assay.
Jan M Schmidt, Mayuri Prasad, Kenna Degner, Rebecca Schiavo, Allison Repic, Dominique Brees

Front Immunol· November 2025

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Innovative Medicines Initiative public-private partnerships to enhance translational safety.
Salah-Dine Chibout, Dominique Brees, Magda Chlebus, Philippe Detilleux, Loic Laplanche

Nat Rev Drug Discov· October 2025

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The challenge to identify sensitive safety biomarkers of peripheral neurotoxicity in the rat: A collaborative effort across industry and academia (IMI NeuroDeRisk project).
Laura Micheli, David Balayssac, Jérôme Busserolles, Cristelle Dalbos, Laetitia Prival, Dominique Brees

Toxicology· January 2025

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Characterizing Antisense Oligonucleotide-Induced Histopathology Findings in Spinal Cord of Mauritius Cynomolgus Monkeys by Molecular Localization Investigation.
Valérie Dubost, Kuno Wuersch, Kelley Penraat, Eric Johnson, Anja Wekkeli, Dominique Brees

Toxicol Pathol· January 2025

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Digital quantitation of bridging fibrosis and septa reveals changes in natural history and treatment not seen with conventional histology.
Nikolai V Naoumov, David E Kleiner, Elaine Chng, Dominique Brees, Chandra Saravanan

Liver Int· December 2024

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Patients with naproxen-induced liver injury display T-cell memory responses toward an oxidative (S)-O-desmethyl naproxen metabolite but not the acyl glucuronide.
Paul Thomson, Nik Fragkas, Laila M Kafu, Guruprasad P Aithal, M Isabel Lucena, Dominique Brees

Allergy· January 2024

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Neurofilament Light Chain: A Translational Safety Biomarker for Drug-Induced Peripheral Neurotoxicity.
Diethilde Theil, Jens Kuhle, Dominique Brees, Elaine Tritto, François Pognan

Toxicol Pathol· April 2023

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Anti-brolucizumab immune response as one prerequisite for rare retinal vasculitis/retinal vascular occlusion adverse events.
Anette C Karle, Matthias B Wrobel, Stephan Koepke, Michael Gutknecht, Sascha Gottlieb, Ingrid Pruimboom-Brees, Dominique Brees

Sci Transl Med· February 2023

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A root cause analysis to identify the mechanistic drivers of immunogenicity against the anti-VEGF biotherapeutic brolucizumab.
Jeffrey D Kearns, Paul Wassmann, Ufuk Olgac, Marie Fichter, Brigitte Christen, Dominique Brees

Sci Transl Med· February 2023

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Digital pathology with artificial intelligence analyses provides greater insights into treatment-induced fibrosis regression in NASH.
Nikolai V Naoumov, Dominique Brees, Juergen Loeffler, Elaine Chng, Yayun Ren

J Hepatol· November 2022

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Therapeutic antibody glycosylation impacts antigen recognition and immunogenicity.
Babette Wolf, Mateusz Piksa, Isabelle Beley, Agnes Patoux, Thierry Besson, Dominique Brees

Immunology· July 2022

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Effect of ofatumumab on pregnancy, parturition, and lactation in cynomolgus monkeys.
Muriel Bellot, C Marc Luetjens, Morten Bagger, Courtney Horvath, Esther Sutter, Dominique Brees

Reprod Toxicol· March 2022

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The use of emerging safety biomarkers in nonclinical and clinical safety assessment - The current and future state: An IQ DruSafe industry survey.
Tanja S Zabka, John Burkhardt, William J Reagan, Jean-Charles Gautier, Warren E Glaab, Dominique Brees

Regul Toxicol Pharmacol· March 2021

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TNF-α antagonists differentially induce TGF-β1-dependent resuscitation of dormant-like Mycobacterium tuberculosis.
Ainhoa Arbués, Dominique Brees, Salah-Dine Chibout, Todd Fox, Michael Kammüller

PLoS Pathog· February 2020

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Safety differentiation: emerging competitive edge in drug development.
Marianne Uteng, Laszlo Urban, Dominique Brees, Patrick Y Muller, Gerd A Kullak-Ublick

Drug Discov Today· January 2019

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Inhibition of IL-17A by secukinumab shows no evidence of increased infections.
Michael Kammüller, Tsen-Fang Tsai, Christopher Em Griffiths, Nidhi Kapoor, Pappachan E Kolattukudy, Dominique Brees

Clin Transl Immunology· August 2017

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Controlled Mycobacterium tuberculosis infection in mice under treatment with anti-IL-17A or IL-17F antibodies, in contrast to TNFα neutralization.
Noria Segueni, Elaine Tritto, Marie-Laure Bourigault, Stéphanie Rose, François Erard, Dominique Brees

Sci Rep· November 2016

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Alisporivir Has Limited Antiviral Effects Against Ebola Virus Strains Makona and Mayinga.
Abhilash I Chiramel, Logan Banadyga, Jonathan D Dougherty, Darryl Falzarano, Cynthia Martellaro, Dominique Brees

J Infect Dis· October 2016

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Antibody blockade of IL-17 family cytokines in immunity to acute murine oral mucosal candidiasis.
Natasha Whibley, Elaine Tritto, Elisabetta Traggiai, Frank Kolbinger, Pierre Moulin, Dominique Brees

J Leukoc Biol· June 2016

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Rat Urinary Osteopontin and Neutrophil Gelatinase-Associated Lipocalin Improve Certainty of Detecting Drug-Induced Kidney Injury.
Jonathan A Phillips, Daniel J Holder, Daniela Ennulat, Jean-Charles Gautier, John-Michael Sauer, Dominique Brees

Toxicol Sci· June 2016

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Minipigs in Translational Immunosafety Sciences: A Perspective.
Tina Rubic-Schneider, Brigitte Christen, Dominique Brees, Michael Kammüller

Toxicol Pathol· April 2016

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Metabolic adaptive ALT isoenzyme response in livers of C57/BL6 mice treated with dexamethasone.
William J Reagan, Rong-Ze Yang, Soohyun Park, Richard Goldstein, Dominique Brees

Toxicol Pathol· December 2012

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Investigative safety science as a competitive advantage for Pharma.
Jonathan Moggs, Pierre Moulin, Francois Pognan, Dominique Brees, Michele Leonard

Expert Opin Drug Metab Toxicol· September 2012

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Quantitative analyses and transcriptomic profiling of circulating messenger RNAs as biomarkers of rat liver injury.
Barbara A Wetmore, Dominique J Brees, Reetu Singh, Paul B Watkins, Melvin E Andersen

Hepatology· June 2010

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