Publications by authors named "Jordan U Gutterman"

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Can natural selection and druggable targets synergize? Of nutrient scarcity, cancer, and the evolution of cooperation.
Neil W Blackstone, Jordan U Gutterman

Bioessays· February 2021

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Avicin G is a potent sphingomyelinase inhibitor and blocks oncogenic K- and H-Ras signaling.
Christian M Garrido, Karen M Henkels, Kristen M Rehl, Hong Liang, Yong Zhou, Jordan U Gutterman

Sci Rep· June 2020

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Glycosylation facilitates transdermal transport of macromolecules.
Christopher J Pino, Jordan U Gutterman, Daniel Vonwil, Samir Mitragotri, V Prasad Shastri

Proc Natl Acad Sci U S A· December 2012

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The anticancer plant triterpenoid, avicin D, regulates glucocorticoid receptor signaling: implications for cellular metabolism.
Valsala Haridas, Zhi-Xiang Xu, Doug Kitchen, Anna Jiang, Peter Michels, Jordan U Gutterman

PLoS One· April 2012

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Red blood cell permeabilization by hypotonic treatments, saponin, and anticancer avicins.
Mauricio Arias, Jairo C Quijano, Valsala Haridas, Jordan U Gutterman, Victor V Lemeshko

Biochim Biophys Acta· June 2010

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Natural triterpenoid avicins selectively induce tumor cell death.
Huibo Wang, Valsala Haridas, Jordan U Gutterman, Zhi-Xiang Xu

Commun Integr Biol· May 2010

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Avicin D, a plant triterpenoid, induces cell apoptosis by recruitment of Fas and downstream signaling molecules into lipid rafts.
Zhi-Xiang Xu, Tian Ding, Valsala Haridas, Fiona Connolly, Jordan U Gutterman

PLoS One· December 2009

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Avicin D: a protein reactive plant isoprenoid dephosphorylates Stat 3 by regulating both kinase and phosphatase activities.
Valsala Haridas, Goshi Nishimura, Zhi-Xiang Xu, Fiona Connolly, Margaret Hanausek, Jordan U Gutterman

PLoS One· August 2009

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Avicin D selectively induces apoptosis and downregulates p-STAT-3, bcl-2, and survivin in cutaneous T-cell lymphoma cells.
Chunlei Zhang, Baoqiang Li, Amos S Gaikwad, Valsala Haridas, Zhixiang Xu, Jordan U Gutterman

J Invest Dermatol· November 2008

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Three catalytic lives linked by the Lasker Awards.
Jordan U Gutterman, Neen Hunt

Nat Med· October 2008

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Avicins, a novel plant-derived metabolite lowers energy metabolism in tumor cells by targeting the outer mitochondrial membrane.
Valsala Haridas, Xiaoxian Li, Takatsugu Mizumachi, Masahiro Higuchi, Viktor V Lemeshko, Jordan U Gutterman

Mitochondrion· May 2007

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The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis.
Jiyong Liang, Shan H Shao, Zhi-Xiang Xu, Bryan Hennessy, Zhiyong Ding, Jordan U Gutterman

Nat Cell Biol· February 2007

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Avicins, natural anticancer saponins, permeabilize mitochondrial membranes.
Victor V Lemeshko, Valsala Haridas, Jairo C Quijano Pérez, Jordan U Gutterman

Arch Biochem Biophys· October 2006

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Effects of the tumor inhibitory triterpenoid avicin G on cell integrity, cytokinesis, and protein ubiquitination in fission yeast.
Jordan U Gutterman, Hong T Lai, Peirong Yang, Valsala Haridas, Amos Gaikwad

Proc Natl Acad Sci U S A· September 2005

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Avicinylation (thioesterification): a protein modification that can regulate the response to oxidative and nitrosative stress.
Valsala Haridas, Sung-Oog Kim, Goshi Nishimura, Alfred Hausladen, Jonathan S Stamler, Jordan U Gutterman

Proc Natl Acad Sci U S A· July 2005

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Proapoptotic triterpene electrophiles (avicins) form channels in membranes: cholesterol dependence.
Xiao Xian Li, Bridgette Davis, Valsala Haridas, Jordan U Gutterman, Marco Colombini

Biophys J· April 2005

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Mitochondria as integrators of information in an early-evolving animal: insights from a triterpenoid metabolite.
Neil W Blackstone, Molly M Kelly, Valsala Haridas, Jordan U Gutterman

Proc Biol Sci· March 2005

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Triterpenoid electrophiles (avicins) activate the innate stress response by redox regulation of a gene battery.
Valsala Haridas, Margaret Hanausek, Goshi Nishimura, Holly Soehnge, Amos Gaikwad, Jordan U Gutterman

J Clin Invest· January 2004

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Isolation and structures of avicins D and G: in vitro tumor-inhibitory saponins derived from Acacia victoriae.
Gamini S Jayatilake, Delano R Freeberg, Zhengjie Liu, Steve L Richheimer, Mary E Blake Nieto, Jordan U Gutterman

J Nat Prod· June 2003

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Metabolomics of plant saponins: bioprospecting triterpene glycoside diversity with respect to mammalian cell targets.
Lokesh Joshi, Joyce M Van Eck, Kristin Mayo, Regina Di Silvestro, Mary E Blake Nieto, Jordan U Gutterman

OMICS· March 2003

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