Publications by authors named "Joseph A Ware"

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Bioequivalence and Relative Bioavailability Studies to Assess a New Acalabrutinib Formulation That Enables Coadministration With Proton-Pump Inhibitors.
Shringi Sharma, Xavier Pepin, Harini Burri, Lianqing Zheng, Nataliya Kuptsova-Clarkson, Joseph A Ware

Clin Pharmacol Drug Dev· November 2022

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Bioavailability of acalabrutinib suspension delivered via nasogastric tube in the presence or absence of a proton pump inhibitor in healthy subjects.
Shringi Sharma, Xavier Pepin, Jean Cheung, Lianqing Zheng, Hua Wei, Joseph A Ware

Br J Clin Pharmacol· October 2022

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Evaluation of the Pharmacokinetics and Safety of a Single Dose of Acalabrutinib in Subjects With Hepatic Impairment.
Yan Xu, Raquel Izumi, Helen Nguyen, Anna Kwan, Howard Kuo, Joseph A Ware

J Clin Pharmacol· June 2022

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Quantitative systems pharmacology model-based investigation of adverse gastrointestinal events associated with prolonged treatment with PI3-kinase inhibitors.
Kapil Gadkar, Christina Friedrich, Vincent Hurez, Maria-Luisa Ruiz, Leslie Dickmann, Joseph A Ware

CPT Pharmacometrics Syst Pharmacol· May 2022

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Mechanistic physiology-based pharmacokinetic modeling to elucidate vincristine-induced peripheral neuropathy following treatment with novel kinase inhibitors.
Venkatesh Pilla Reddy, Adrian J Fretland, Diansong Zhou, Shringi Sharma, Buyun Chen, Joseph A Ware

Cancer Chemother Pharmacol· September 2021

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Absorption, metabolism and excretion of pictilisib, a potent pan-class I phosphatidylinositol-3-Kinase (PI3K) inhibitor, in rats, dogs, and humans.
Qin Yue, S Cyrus Khojasteh, Sungjoon Cho, Shuguang Ma, Teresa Mulder, Joseph A Ware

Xenobiotica· July 2021

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Intrinsic and Extrinsic Pharmacokinetic Variability of Small Molecule Targeted Cancer Therapy.
Eric Reyner, Bert Lum, Jing Jing, Matts Kagedal, Joseph A Ware

Clin Transl Sci· March 2020

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Investigation of the absolute bioavailability and human mass balance of navoximod, a novel IDO1 inhibitor.
Shuguang Ma, Julia Suchomel, Evelyn Yanez, Edward Yost, Xiaorong Liang, Joseph A Ware

Br J Clin Pharmacol· August 2019

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Disease-Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium.
Raymond Evers, Micheline Piquette-Miller, Joseph W Polli, Frans G M Russel, Jason A Sprowl, Joseph A Ware

Clin Pharmacol Ther· November 2018

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ITC Commentary on Metformin Clinical Drug-Drug Interaction Study Design That Enables an Efficacy- and Safety-Based Dose Adjustment Decision.
Maciej J Zamek-Gliszczynski, Xiaoyan Chu, Jack A Cook, Joseph M Custodio, Aleksandra Galetin, Joseph A Ware

Clin Pharmacol Ther· November 2018

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A Phase I Dose-Escalation Study of the Safety and Pharmacokinetics of Pictilisib in Combination with Erlotinib in Patients with Advanced Solid Tumors.
Stephen Leong, Rebecca A Moss, Daniel W Bowles, Joseph A Ware, Jing Zhou

Oncologist· December 2017

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Combining "Bottom-up" and "Top-down" Approaches to Assess the Impact of Food and Gastric pH on Pictilisib (GDC-0941) Pharmacokinetics.
Tong Lu, Grazyna Fraczkiewicz, Laurent Salphati, Nageshwar Budha, Gena Dalziel, Joseph A Ware

CPT Pharmacometrics Syst Pharmacol· November 2017

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Phase I Dose-Escalation Study of Taselisib, an Oral PI3K Inhibitor, in Patients with Advanced Solid Tumors.
Dejan Juric, Ian Krop, Ramesh K Ramanathan, Timothy R Wilson, Joseph A Ware

Cancer Discov· July 2017

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Pharmacogenomics in the age of personalized medicine.
Leslie J Dickmann, Joseph A Ware

Drug Discov Today Technol· February 2017

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A multicenter, single-arm, open-label, phase 2 study of apitolisib (GDC-0980) for the treatment of recurrent or persistent endometrial carcinoma (MAGGIE study).
Vicky Makker, Fernando O Recio, Ling Ma, Ursula A Matulonis, Jennifer O Lauchle, Joseph A Ware

Cancer· November 2016

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Corrigendum to "Simultaneous determination of itraconazole, hydroxy itraconazole, keto itraconazole and N-desalkyl itraconazole concentration in human plasma using liquid chromatography with tandem mass spectrometry" [J. Chromatogr. B 1020 (2016) 111-119].
Xiaorong Liang, Michael Van Parys, Xiao Ding, Ning Zeng, Luke Bi, Joseph A Ware

J Chromatogr B Analyt Technol Biomed Life Sci· September 2016

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Phase I Study of Apitolisib (GDC-0980), Dual Phosphatidylinositol-3-Kinase and Mammalian Target of Rapamycin Kinase Inhibitor, in Patients with Advanced Solid Tumors.
Saoirse O Dolly, Andrew J Wagner, Johanna C Bendell, Hedy L Kindler, Lee M Krug, Joseph A Ware

Clin Cancer Res· June 2016

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Randomized Open-Label Phase II Trial of Apitolisib (GDC-0980), a Novel Inhibitor of the PI3K/Mammalian Target of Rapamycin Pathway, Versus Everolimus in Patients With Metastatic Renal Cell Carcinoma.
Thomas Powles, Mark R Lackner, Stéphane Oudard, Bernard Escudier, Christy Ralph, Joseph A Ware

J Clin Oncol· May 2016

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Simultaneous determination of itraconazole, hydroxy itraconazole, keto itraconazole and N-desalkyl itraconazole concentration in human plasma using liquid chromatography with tandem mass spectrometry.
Xiaorong Liang, Michael Van Parys, Xiao Ding, Ning Zeng, Luke Bi, Joseph A Ware

J Chromatogr B Analyt Technol Biomed Life Sci· May 2016

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Breast cancer resistance protein (ABCG2) in clinical pharmacokinetics and drug interactions: practical recommendations for clinical victim and perpetrator drug-drug interaction study design.
Caroline A Lee, Meeghan A O'Connor, Tasha K Ritchie, Aleksandra Galetin, Jack A Cook, Joseph A Ware

Drug Metab Dispos· April 2015

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First-in-human phase I study of pictilisib (GDC-0941), a potent pan-class I phosphatidylinositol-3-kinase (PI3K) inhibitor, in patients with advanced solid tumors.
Debashis Sarker, Joo Ern Ang, Richard Baird, Rebecca Kristeleit, Krunal Shah, Joseph A Ware

Clin Cancer Res· January 2015

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Breast cancer resistance protein substrate and inhibition evaluation: why, when, and how?
Joseph A Ware, Bradley L Urquhart, Yuichi Sugiyama, Maciej J Zamek-Gliszczynski

Drug Metab Dispos· December 2014

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The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria.
Marc R Yago, Adam Frymoyer, Leslie Z Benet, Gillian S Smelick, Lynda A Frassetto, Joseph A Ware

AAPS J· November 2014

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Impact of food and the proton pump inhibitor rabeprazole on the pharmacokinetics of GDC-0941 in healthy volunteers: bench to bedside investigation of pH-dependent solubility.
Joseph A Ware, Gena Dalziel, Jin Y Jin, Jackson D Pellett, Gillian S Smelick

Mol Pharm· November 2013

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Physical chemical drug-drug interactions from drug discovery to registration: new opportunities for the pharmaceutical scientist to impact drug development.
Joseph A Ware, Gena Dalziel

Mol Pharm· November 2013

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