Publications by authors named "Joseph D Mougous"

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Accurate de novo design of high-affinity protein-binding macrocycles using deep learning.
Stephen A Rettie, David Juergens, Victor Adebomi, Yensi Flores Bueso, Qinqin Zhao, Joseph D Mougous

Nat Chem Biol· December 2025

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De Novo Design of High-Affinity Miniprotein Binders Targeting Francisella Tularensis Virulence Factor.
Gizem Gokce-Alpkilic, Buwei Huang, Andi Liu, Lieselotte S M Kreuk, Yaxi Wang, Joseph D Mougous

Angew Chem Int Ed Engl· December 2025

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The unique architecture of umbrella toxins permits a two-tiered molecular bet-hedging strategy for interbacterial antagonism.
Qinqin Zhao, Jiri Vlach, Young-Jun Park, Yongjun Tan, Savannah K Bertolli, Joseph D Mougous

Cell· December 2025

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An electron transport complex required in the gut sensitizes to a pore-forming type VI secretion toxin.
Hannah K Ratner, Brandon D Duong, Pengrui Miao, Savannah K Bertolli, Beth A Shen, Joseph D Mougous

Proc Natl Acad Sci U S A· December 2025

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The type VI secretion system governs strain maintenance in a wild mammalian gut microbiome.
Beth A Shen, Kyle L Asfahl, Bentley Lim, Savannah K Bertolli, Samuel S Minot, Joseph D Mougous

bioRxiv· December 2025

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Pseudomonads coordinate innate defense against viruses and bacteria with a single regulatory system.
David M Brinkley, Savannah K Bertolli, Larry A Gallagher, Yongjun Tan, Minola Motha de Silva, Joseph D Mougous

Cell Host Microbe· August 2025

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De novo design of high-affinity miniprotein binders targeting virulence factor.
Gizem Gokce-Alpkilic, Buwei Huang, Andi Liu, Lieselotte S M Kreuk, Yaxi Wang, Joseph D Mougous

bioRxiv· July 2025

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Twists, turns and jumps: T6SS evolution within species.
Beth A Shen, S Brook Peterson, Joseph D Mougous

Trends Microbiol· April 2025

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Pseudomonads coordinate innate defense against viruses and bacteria with a single regulatory system.
David M Brinkley, Savannah K Bertolli, Larry A Gallagher, Yongjun Tan, Minola Motha de Silva, Joseph D Mougous

bioRxiv· February 2025

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Beyond genomics in Patescibacteria: A trove of unexplored biology packed into ultrasmall bacteria.
Pooja Srinivas, S Brook Peterson, Larry A Gallagher, Yaxi Wang, Joseph D Mougous

Proc Natl Acad Sci U S A· December 2024

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Accurate design of high-affinity protein binding macrocycles using deep learning.
Stephen A Rettie, David Juergens, Victor Adebomi, Yensi Flores Bueso, Qinqin Zhao, Joseph D Mougous

bioRxiv· November 2024

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Protein interactions in human pathogens revealed through deep learning.
Ian R Humphreys, Jing Zhang, Minkyung Baek, Yaxi Wang, Aditya Krishnakumar, Joseph D Mougous

Nat Microbiol· October 2024

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Streptomyces umbrella toxin particles block hyphal growth of competing species.
Qinqin Zhao, Savannah Bertolli, Young-Jun Park, Yongjun Tan, Kevin J Cutler, Joseph D Mougous

Nature· May 2024

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Essential and virulence-related protein interactions of pathogens revealed through deep learning.
Ian R Humphreys, Jing Zhang, Minkyung Baek, Yaxi Wang, Aditya Krishnakumar, Joseph D Mougous

bioRxiv· April 2024

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Genetic manipulation of Patescibacteria provides mechanistic insights into microbial dark matter and the epibiotic lifestyle.
Yaxi Wang, Larry A Gallagher, Pia A Andrade, Andi Liu, Ian R Humphreys, Joseph D Mougous

Cell· October 2023

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Structural disruption of Ntox15 nuclease effector domains by immunity proteins protects against type VI secretion system intoxication in Bacteroidales.
Dustin E Bosch, Romina Abbasian, Bishal Parajuli, S Brook Peterson, Joseph D Mougous

mBio· August 2023

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Discovery of a glutathione utilization pathway in Francisella that shows functional divergence between environmental and pathogenic species.
Yaxi Wang, Hannah E Ledvina, Catherine A Tower, Stanimir Kambarev, Elizabeth Liu, Joseph D Mougous

Cell Host Microbe· August 2023

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Genetic manipulation of candidate phyla radiation bacteria provides functional insights into microbial dark matter.
Yaxi Wang, Larry A Gallagher, Pia A Andrade, Andi Liu, Ian R Humphreys, Joseph D Mougous

bioRxiv· May 2023

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Omnipose: a high-precision morphology-independent solution for bacterial cell segmentation.
Kevin J Cutler, Carsen Stringer, Teresa W Lo, Luca Rappez, Nicholas Stroustrup, Joseph D Mougous

Nat Methods· November 2022

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Genome-wide protein-DNA interaction site mapping in bacteria using a double-stranded DNA-specific cytosine deaminase.
Larry A Gallagher, Elena Velazquez, S Brook Peterson, James C Charity, Matthew C Radey, Joseph D Mougous

Nat Microbiol· June 2022

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Discovery of coordinately regulated pathways that provide innate protection against interbacterial antagonism.
See-Yeun Ting, Kaitlyn D LaCourse, Hannah E Ledvina, Rutan Zhang, Matthew C Radey, Joseph D Mougous

Elife· February 2022

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An interbacterial DNA deaminase toxin directly mutagenizes surviving target populations.
Marcos H de Moraes, FoSheng Hsu, Dean Huang, Dustin E Bosch, Jun Zeng, Joseph D Mougous

Elife· January 2021

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The Central Role of Interbacterial Antagonism in Bacterial Life.
S Brook Peterson, Savannah K Bertolli, Joseph D Mougous

Curr Biol· October 2020

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A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing.
Beverly Y Mok, Marcos H de Moraes, Jun Zeng, Dustin E Bosch, Anna V Kotrys, Joseph D Mougous

Nature· July 2020

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Tn-Seq reveals hidden complexity in the utilization of host-derived glutathione in Francisella tularensis.
Kathryn M Ramsey, Hannah E Ledvina, Tenayaann M Tresko, Jamie M Wandzilak, Catherine A Tower, Joseph D Mougous

PLoS Pathog· June 2020

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