Publications by authors named "Joseph Dempsey"

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Soluble Triggering Receptor Expressed on Myeloid Cells 2 is a Biomarker but Not a Mediator of Fibrosing Steatohepatitis.
Joseph L Dempsey, Christopher Savard, Vishal Kothari, Jingjing Tang, Sum P Lee

Gastro Hep Adv· December 2025

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Defining key parameters of therapeutic activity using mouse cancer neoepitopes.
Summit Singhaviranon, Joseph P Dempsey, Hakimeh Ebrahimi-Nik, Pramod Kumar Srivastava

J Immunol· September 2025

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Soluble TREM2 is a biomarker but not a mediator of fibrosing steatohepatitis.
Joseph L Dempsey, Christopher Savard, Vishal Kothari, Jingjing Tang, Sum P Lee

bioRxiv· March 2025

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Low-avidity T cells drive endogenous tumor immunity in mice and humans.
Summit Singhaviranon, Joseph P Dempsey, Adam T Hagymasi, Ion I Mandoiu, Pramod K Srivastava

Nat Immunol· February 2025

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Oral exposure to benzalkonium chlorides in male and female mice reveals alteration of the gut microbiome and bile acid profile.
Vanessa A Lopez, Joe J Lim, Ryan P Seguin, Joseph L Dempsey, Gabrielle Kunzman

Toxicol Sci· December 2024

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Oral Exposure to Benzalkonium Chlorides in Male and Female Mice Reveals Sex-Dependent Alteration of the Gut Microbiome and Bile Acid Profile.
Vanessa A Lopez, Joe L Lim, Ryan P Seguin, Joseph L Dempsey, Gabrielle Kunzman

bioRxiv· May 2024

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A missense variant in human perilipin 2 ( Ser251Pro) reduces hepatic steatosis in mice.
Eleonora Scorletti, Yedidya Saiman, Sookyoung Jeon, Carolin V Schneider, Delfin G Buyco, Joseph L Dempsey

JHEP Rep· January 2024

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Ceramide synthase 6 (CerS6) is upregulated in alcohol-associated liver disease and exhibits sex-based differences in the regulation of energy homeostasis and lipid droplet accumulation.
Sookyoung Jeon, Eleonora Scorletti, Joseph Dempsey, Delfin Buyco, Chelsea Lin

Mol Metab· December 2023

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Mechanisms of Lipid Droplet Accumulation in Steatotic Liver Diseases.
Joseph L Dempsey, George N Ioannou, Rotonya M Carr

Semin Liver Dis· November 2023

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Concomitant western diet and chronic-binge alcohol dysregulate hepatic metabolism.
Delfin Gerard Buyco, Joseph L Dempsey, Eleonora Scorletti, Sookyoung Jeon, Chelsea Lin

PLoS One· May 2023

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Heat-Shock Proteins.
Adam T Hagymasi, Joseph P Dempsey, Pramod K Srivastava

Curr Protoc· November 2022

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Neonatal Exposure to BPA, BDE-99, and PCB Produces Persistent Changes in Hepatic Transcriptome Associated With Gut Dysbiosis in Adult Mouse Livers.
Joe Jongpyo Lim, Moumita Dutta, Joseph L Dempsey, Hans-Joachim Lehmler, James MacDonald

Toxicol Sci· October 2021

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Impact of Microbiome on Hepatic Metabolizing Enzymes and Transporters in Mice during Pregnancy.
Lyrialle W Han, Lu Wang, Yuanyuan Shi, Joseph L Dempsey, Olesya V Pershutkina

Drug Metab Dispos· August 2020

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Chronic G signaling in AgRP neurons does not cause obesity.
Sedona N Ewbank, Carlos A Campos, Jane Y Chen, Anna J Bowen, Stephanie L Padilla, Joseph L Dempsey

Proc Natl Acad Sci U S A· August 2020

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Gut microbiome: An intermediary to neurotoxicity.
Joseph L Dempsey, Mallory Little, Julia Yue Cui

Neurotoxicology· December 2019

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Metabolism of Benzalkonium Chlorides by Human Hepatic Cytochromes P450.
Ryan P Seguin, Josi M Herron, Vanessa A Lopez, Joseph L Dempsey, Libin Xu

Chem Res Toxicol· December 2019

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Microbiome is a functional modifier of P450 drug metabolism.
Joseph L Dempsey, Julia Yue Cui

Curr Pharmacol Rep· December 2019

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Polybrominated Diphenyl Ethers and Gut Microbiome Modulate Metabolic Syndrome-Related Aqueous Metabolites in Mice.
David K Scoville, Cindy Yanfei Li, Dongfang Wang, Joseph L Dempsey, Daniel Raftery

Drug Metab Dispos· August 2019

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Pharmacological Activation of PXR and CAR Downregulates Distinct Bile Acid-Metabolizing Intestinal Bacteria and Alters Bile Acid Homeostasis.
Joseph L Dempsey, Dongfang Wang, Gunseli Siginir, Qiang Fei, Daniel Raftery

Toxicol Sci· March 2019

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Regulation of Hepatic Long Noncoding RNAs by Pregnane X Receptor and Constitutive Androstane Receptor Agonists in Mouse Liver.
Joseph L Dempsey, Julia Yue Cui

Drug Metab Dispos· March 2019

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Coordinate regulation of long non-coding RNAs and protein-coding genes in germ-free mice.
Joseph Dempsey, Angela Zhang, Julia Yue Cui

BMC Genomics· November 2018

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PBDEs Altered Gut Microbiome and Bile Acid Homeostasis in Male C57BL/6 Mice.
Cindy Yanfei Li, Joseph L Dempsey, Dongfang Wang, SooWan Lee, Kris M Weigel

Drug Metab Dispos· August 2018

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Physiological Regulation of Drug Metabolism and Transport: Pregnancy, Microbiome, Inflammation, Infection, and Fasting.
Edward T Morgan, Joseph L Dempsey, Sylvie M Mimche, Tracey J Lamb, Supriya Kulkarni

Drug Metab Dispos· May 2018

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Long Non-Coding RNAs: A Novel Paradigm for Toxicology.
Joseph L Dempsey, Julia Yue Cui

Toxicol Sci· January 2017

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