Publications by authors named "Joseph Gera"

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A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells.
Xiaoyong Chen, Xiangjun Tang, Ying Xie, Benedette J Cuffari, Caroline Tang, Joseph Gera

Sci Signal· March 2025

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Cellular protection from HO toxicity by Fv-Hsp70: protection via catalase and gamma-glutamyl-cysteine synthase.
Chris Hino, Grace Chan, Gwen Jordaan, Sophia S Chang, Jacquelyn T Saunders, Joseph Gera

Cell Stress Chaperones· July 2023

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mA-modification of cyclin D1 and c-myc IRESs in glioblastoma controls ITAF activity and resistance to mTOR inhibition.
Angelica Benavides-Serrato, Jacquelyn T Saunders, Sunil Kumar, Brent Holmes, Kennedy E Benavides, Joseph Gera

Cancer Lett· May 2023

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Translation of circHGF RNA encodes an HGF protein variant promoting glioblastoma growth through stimulation of c-MET.
Jacquelyn T Saunders, Sunil Kumar, Angelica Benavides-Serrato, Brent Holmes, Kennedy E Benavides, Joseph Gera

J Neurooncol· May 2023

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Critical Role for Cap-Independent c-MYC Translation in Progression of Multiple Myeloma.
Yijiang Shi, Fumou Sun, Yan Cheng, Brent Holmes, Binod Dhakal, Joseph F Gera

Mol Cancer Ther· April 2022

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Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation.
Mario Vega, Yu Chen, Yijiang Shi, Joseph Gera, Alan Lichtenstein

J Biol Chem· April 2022

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Hypocretin/Orexin Interactions with Norepinephrine Contribute to the Opiate Withdrawal Syndrome.
Ronald McGregor, Ming-Fung Wu, Brent Holmes, Hoa Anh Lam, Nigel T Maidment, Joseph Gera

J Neurosci· January 2022

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mTORC2-mediated direct phosphorylation regulates YAP activity promoting glioblastoma growth and invasive characteristics.
Brent Holmes, Angelica Benavides-Serrato, Jacquelyn T Saunders, Sunil Kumar, Robert N Nishimura, Joseph Gera

Neoplasia· September 2021

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Targeting the YAP-TEAD interaction interface for therapeutic intervention in glioblastoma.
Jacquelyn T Saunders, Brent Holmes, Angelica Benavides-Serrato, Sunil Kumar, Robert N Nishimura, Joseph Gera

J Neurooncol· April 2021

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Repurposing Potential of Riluzole as an ITAF Inhibitor in mTOR Therapy Resistant Glioblastoma.
Angelica Benavides-Serrato, Jacquelyn T Saunders, Brent Holmes, Robert N Nishimura, Alan Lichtenstein, Joseph Gera

Int J Mol Sci· January 2020

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A Novel Therapeutic Induces DEPTOR Degradation in Multiple Myeloma Cells with Resulting Tumor Cytotoxicity.
Mario I Vega, Yijiang Shi, Patrick Frost, Sara Huerta-Yepez, Gabriela Antonio-Andres, Joseph F Gera

Mol Cancer Ther· October 2019

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The protein arginine methyltransferase PRMT5 confers therapeutic resistance to mTOR inhibition in glioblastoma.
Brent Holmes, Angelica Benavides-Serrato, Jacquelyn T Saunders, Kenna A Landon, Adam J Schreck, Joseph Gera

J Neurooncol· October 2019

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Correction: Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma.
Angelica Benavides-Serrato, Jihye Lee, Brent Holmes, Kenna A Landon, Tariq Bashir, Joseph Gera

PLoS One· February 2019

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Structure-activity relationship study of small molecule inhibitors of the DEPTOR-mTOR interaction.
Jihye Lee, Yijiang Shi, Mario Vega, Yonghui Yang, Joseph Gera

Bioorg Med Chem Lett· October 2017

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Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma.
Angelica Benavides-Serrato, Jihye Lee, Brent Holmes, Kenna A Landon, Tariq Bashir, Joseph Gera

PLoS One· September 2017

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Cytotoxic Properties of a DEPTOR-mTOR Inhibitor in Multiple Myeloma Cells.
Yijiang Shi, Tracy R Daniels-Wells, Patrick Frost, Jihye Lee, Richard S Finn, Joseph Gera

Cancer Res· October 2016

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Mechanistic Target of Rapamycin (mTOR) Inhibition Synergizes with Reduced Internal Ribosome Entry Site (IRES)-mediated Translation of Cyclin D1 and c-MYC mRNAs to Treat Glioblastoma.
Brent Holmes, Jihye Lee, Kenna A Landon, Angelica Benavides-Serrato, Tariq Bashir, Joseph Gera

J Biol Chem· July 2016

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Phosphorylation of the Hippo Pathway Component AMOTL2 by the mTORC2 Kinase Promotes YAP Signaling, Resulting in Enhanced Glioblastoma Growth and Invasiveness.
Nicholas Artinian, Cheri Cloninger, Brent Holmes, Angelica Benavides-Serrato, Tariq Bashir, Joseph Gera

J Biol Chem· August 2015

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MNK1-induced eIF-4E phosphorylation in myeloma cells: a pathway mediating IL-6-induced expansion and expression of genes involved in metabolic and proteotoxic responses.
Yijiang Shi, Patrick Frost, Bao Hoang, Yonghui Yang, Carolyne Bardeleben, Joseph Gera

PLoS One· January 2015

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mTORC2 modulates feedback regulation of p38 MAPK activity via DUSP10/MKP5 to confer differential responses to PP242 in glioblastoma.
Angelica Benavides-Serrato, Lauren Anderson, Brent Holmes, Cheri Cloninger, Nicholas Artinian, Joseph Gera

Genes Cancer· November 2014

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DEPTOR is linked to a TORC1-p21 survival proliferation pathway in multiple myeloma cells.
Yonghui Yang, Carolyne Bardeleben, Patrick Frost, Bao Hoang, Yijiang Shi, Joseph Gera

Genes Cancer· November 2014

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Conditional astroglial Rictor overexpression induces malignant glioma in mice.
Tariq Bashir, Cheri Cloninger, Nicholas Artinian, Lauren Anderson, Andrew Bernath, Joseph Gera

PLoS One· April 2013

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Mammalian target of rapamycin inhibitors induce tumor cell apoptosis in vivo primarily by inhibiting VEGF expression and angiogenesis.
Patrick Frost, Eileen Berlanger, Veena Mysore, Bao Hoang, Yijiang Shi, Joseph Gera

J Oncol· March 2013

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A cell-penetrating bispecific antibody for therapeutic regulation of intracellular targets.
Richard H Weisbart, Joseph F Gera, Grace Chan, James E Hansen, Erica Li

Mol Cancer Ther· October 2012

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Targeting cancer with a lupus autoantibody.
James E Hansen, Grace Chan, Yanfeng Liu, Denise C Hegan, Shibani Dalal, Joseph Gera

Sci Transl Med· October 2012

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