Publications by authors named "Patrick Frost"

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Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail.
Mysore S Veena, Jungmo J Gahng, Mustafa Alani, Albert Y Ko, Saroj K Basak, Patrick Frost

Cancer Res Commun· March 2024

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Acidification of intracellular pH in MM tumor cells overcomes resistance to hypoxia-mediated apoptosis and .
Gilberto Gastelum, Jeffry Kraut, Mysore Veena, Alisher Baibussinov, Christopher Lamb, Patrick Frost

Front Oncol· November 2023

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AcidoCEST MRI Evaluates the Bone Microenvironment in Multiple Myeloma.
Alecio F Lombardi, Jonathan H Wong, Rachel High, Yajun Ma, Saeed Jerban, Patrick Frost

Mol Imaging Biol· December 2021

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Can Targeting Hypoxia-Mediated Acidification of the Bone Marrow Microenvironment Kill Myeloma Tumor Cells?
Gilberto Gastelum, Mysore Veena, Kylee Lyons, Christopher Lamb, Nicole Jacobs, Patrick Frost

Front Oncol· July 2021

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A Novel Therapeutic Induces DEPTOR Degradation in Multiple Myeloma Cells with Resulting Tumor Cytotoxicity.
Mario I Vega, Yijiang Shi, Patrick Frost, Sara Huerta-Yepez, Gabriela Antonio-Andres

Mol Cancer Ther· October 2019

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Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice.
Gilbert Gastelum, Eric Y Chang, David Shackleford, Nicholas Bernthal, Jeffery Kraut, Patrick Frost

J Vis Exp· January 2019

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Restoration of the prolyl-hydroxylase domain protein-3 oxygen-sensing mechanism is responsible for regulation of HIF2α expression and induction of sensitivity of myeloma cells to hypoxia-mediated apoptosis.
Gilberto Gastelum, Aleksandra Poteshkina, Mysore Veena, Edgar Artiga, Geraldine Weckstein, Patrick Frost

PLoS One· December 2017

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Cytotoxic Properties of a DEPTOR-mTOR Inhibitor in Multiple Myeloma Cells.
Yijiang Shi, Tracy R Daniels-Wells, Patrick Frost, Jihye Lee, Richard S Finn

Cancer Res· October 2016

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SGK Kinase Activity in Multiple Myeloma Cells Protects against ER Stress Apoptosis via a SEK-Dependent Mechanism.
Bao Hoang, Yijiang Shi, Patrick J Frost, Veena Mysore, Carolyne Bardeleben

Mol Cancer Res· April 2016

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A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity.
Veena S Mysore, Jerzy Szablowski, Peter B Dervan, Patrick J Frost

Mol Cancer Res· March 2016

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MNK1-induced eIF-4E phosphorylation in myeloma cells: a pathway mediating IL-6-induced expansion and expression of genes involved in metabolic and proteotoxic responses.
Yijiang Shi, Patrick Frost, Bao Hoang, Yonghui Yang, Carolyne Bardeleben

PLoS One· January 2015

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DEPTOR is linked to a TORC1-p21 survival proliferation pathway in multiple myeloma cells.
Yonghui Yang, Carolyne Bardeleben, Patrick Frost, Bao Hoang, Yijiang Shi

Genes Cancer· November 2014

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Metabolomics identifies pyrimidine starvation as the mechanism of 5-aminoimidazole-4-carboxamide-1-β-riboside-induced apoptosis in multiple myeloma cells.
Carolyne Bardeleben, Sanjai Sharma, Joseph R Reeve, Sara Bassilian, Patrick Frost

Mol Cancer Ther· July 2013

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Dietary β-glucan stimulate complement and C-reactive protein acute phase responses in common carp (Cyprinus carpio) during an Aeromonas salmonicida infection.
Nicolas Pionnier, Alberto Falco, Joanna Miest, Patrick Frost, Ilgiz Irnazarow

Fish Shellfish Immunol· March 2013

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Mammalian target of rapamycin inhibitors induce tumor cell apoptosis in vivo primarily by inhibiting VEGF expression and angiogenesis.
Patrick Frost, Eileen Berlanger, Veena Mysore, Bao Hoang, Yijiang Shi

J Oncol· March 2013

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PAK1 kinase promotes cell motility and invasiveness through CRK-II serine phosphorylation in non-small cell lung cancer cells.
Matthew Rettig, Kenny Trinidad, G Pezeshkpour, Patrick Frost, Sherven Sharma

PLoS One· January 2013

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Reduced inflammatory response to Aeromonas salmonicida infection in common carp (Cyprinus carpio L.) fed with β-glucan supplements.
Alberto Falco, Patrick Frost, Joanna Miest, Nicolas Pionnier, Ilgiz Irnazarow

Fish Shellfish Immunol· June 2012

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The PP242 mammalian target of rapamycin (mTOR) inhibitor activates extracellular signal-regulated kinase (ERK) in multiple myeloma cells via a target of rapamycin complex 1 (TORC1)/eukaryotic translation initiation factor 4E (eIF-4E)/RAF pathway and activation is a mechanism of resistance.
Bao Hoang, Angelica Benavides, Yijiang Shi, Yonghui Yang, Patrick Frost

J Biol Chem· June 2012

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Molecular cloning and expression of two β-defensin and two mucin genes in common carp (Cyprinus carpio L.) and their up-regulation after β-glucan feeding.
Maria van der Marel, Mikołaj Adamek, Santiago F Gonzalez, Patrick Frost, Jan H W M Rombout

Fish Shellfish Immunol· March 2012

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IL-6-induced enhancement of c-Myc translation in multiple myeloma cells: critical role of cytoplasmic localization of the rna-binding protein hnRNP A1.
Yijiang Shi, Patrick Frost, Bao Hoang, Angelica Benavides, Joseph Gera

J Biol Chem· January 2011

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Targeting TORC2 in multiple myeloma with a new mTOR kinase inhibitor.
Bao Hoang, Patrick Frost, Yijiang Shi, Eileen Belanger, Angelica Benavides

Blood· November 2010

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Effect of autophagy on multiple myeloma cell viability.
Bao Hoang, Angelica Benavides, Yijiang Shi, Patrick Frost, Alan Lichtenstein

Mol Cancer Ther· July 2009

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Regulation of D-cyclin translation inhibition in myeloma cells treated with mammalian target of rapamycin inhibitors: rationale for combined treatment with extracellular signal-regulated kinase inhibitors and rapamycin.
Patrick Frost, Yijiang Shi, Bao Hoang, Joseph Gera, Alan Lichtenstein

Mol Cancer Ther· January 2009

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IL-6-induced stimulation of c-myc translation in multiple myeloma cells is mediated by myc internal ribosome entry site function and the RNA-binding protein, hnRNP A1.
Yijiang Shi, Patrick J Frost, Bao Q Hoang, Angelica Benavides, Sanjai Sharma

Cancer Res· December 2008

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Oncogenic RAS mutations in myeloma cells selectively induce cox-2 expression, which participates in enhanced adhesion to fibronectin and chemoresistance.
Bao Hoang, Li Zhu, Yijiang Shi, Patrick Frost, Huajun Yan

Blood· June 2006

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