Publications by authors named "Joseph H Chan"

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1,4-Bis(5-(naphthalen-1-yl)thiophen-2-yl)naphthalene, a small molecule, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular Lens epithelium-derived growth factor.
Wan-gang Gu, Denis Tsz-Ming Ip, Si-jie Liu, Joseph H Chan, Yan Wang

Chem Biol Interact· April 2014

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Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors.
Jingshan Ren, Philip P Chamberlain, Anna Stamp, Steven A Short, Kurt L Weaver, Joseph H Chan

J Med Chem· August 2008

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Relationship of potency and resilience to drug resistant mutations for GW420867X revealed by crystal structures of inhibitor complexes for wild-type, Leu100Ile, Lys101Glu, and Tyr188Cys mutant HIV-1 reverse transcriptases.
Jingshan Ren, Charles E Nichols, Philip P Chamberlain, Kurt L Weaver, Steven A Short, Joseph H Chan

J Med Chem· May 2007

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Structure-activity relationship studies of novel benzophenones leading to the discovery of a potent, next generation HIV nonnucleoside reverse transcriptase inhibitor.
Karen R Romines, George A Freeman, Lee T Schaller, Jill R Cowan, Steve S Gonzales, Joseph H Chan

J Med Chem· January 2006

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Anti-human immunodeficiency virus type 1 activity of the nonnucleoside reverse transcriptase inhibitor GW678248 in combination with other antiretrovirals against clinical isolate viruses and in vitro selection for resistance.
Richard J Hazen, Robert J Harvey, Marty H St Clair, Robert G Ferris, George A Freeman, Joseph H Chan

Antimicrob Agents Chemother· November 2005

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Antiviral activity of GW678248, a novel benzophenone nonnucleoside reverse transcriptase inhibitor.
Robert G Ferris, Richard J Hazen, Grace B Roberts, Marty H St Clair, Joseph H Chan

Antimicrob Agents Chemother· October 2005

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Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1.
Andrew L Hopkins, Jingshan Ren, John Milton, Richard J Hazen, Joseph H Chan

J Med Chem· November 2004

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Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2.
George A Freeman, C Webster Andrews Iii, Andrew L Hopkins, Gina S Lowell, Lee T Schaller, Joseph H Chan

J Med Chem· November 2004

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Novel benzophenones as non-nucleoside reverse transcriptase inhibitors of HIV-1.
Joseph H Chan, George A Freeman, Jeffrey H Tidwell, Karen R Romines, Lee T Schaller

J Med Chem· February 2004

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