Publications by authors named "Joseph Kalen"

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Granzyme B-Targeting Quenched Activity-Based Probes for Assessing Tumor Response to Immunotherapy.
Muhammad Kazim, Arghya Ganguly, Sebastian M Malespini, Lai Thang, Nimit L Patel, Joseph D Kalen

J Am Chem Soc· October 2025

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Tracking the Fate of Therapeutic Proteins Using Ratiometric Imaging of Responsive Shortwave Infrared Probes.
Pradeep Shrestha, Nimit L Patel, Joseph D Kalen, Syed Muhammad Usama, Martin J Schnermann

J Am Chem Soc· March 2025

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Granzyme-targeting quenched activity-based probes for assessing tumor response to immunotherapy.
Muhammad Kazim, Arghya Ganguly, Sebastian M Malespini, Lai Thang, Nimit L Patel, Joseph D Kalen

bioRxiv· March 2025

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Targeting NAD+ Metabolism Vulnerability in FH-Deficient Hereditary Leiomyomatosis and Renal Cell Carcinoma with the Novel NAMPT Inhibitor OT-82.
Susana S Najera, Christopher J Ricketts, Laura S Schmidt, Julia I Medina, Keita Saito, Joseph D Kalen

Mol Cancer Ther· February 2025

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Benzyl Ammonium Carbamates Undergo Two-Step Linker Cleavage and Improve the Properties of Antibody Conjugates.
Xiaoyi Li, Nimit L Patel, Joseph Kalen, Martin J Schnermann

Angew Chem Int Ed Engl· February 2025

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Metastatic organotropism in small cell lung cancer.
Manan Krishnamurthy, Anjali Dhall, Sarthak Sahoo, Christopher W Schultz, Michelle A Baird, Joseph D Kalen

bioRxiv· January 2025

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Toward a CRISPR-based mouse model of -deficient clear cell kidney cancer: Initial experience and lessons learned.
Laura A Stransky, Wenhua Gao, Laura S Schmidt, Kevin Bi, Christopher J Ricketts, Joseph D Kalen

Proc Natl Acad Sci U S A· October 2024

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Preclinical Therapeutic Efficacy of RAF/MEK/ERK and IGF1R/AKT/mTOR Inhibition in Neuroblastoma.
Stacey Stauffer, Jacob S Roth, Edjay R Hernandez, Joshua T Kowalczyk, Nancy E Sealover, Joseph D Kalen

Cancers (Basel)· June 2024

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A dual-luciferase bioluminescence system for the assessment of cellular therapies.
Alejandro G Torres Chavez, Mary K McKenna, Kishore Balasubramanian, Lisa Riffle, Nimit L Patel, Joseph D Kalen

Mol Ther Oncol· March 2024

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Subcutaneous Alfaxalone-XylazineBuprenorphine for Surgical Anesthesia and Echocardiographic Evaluation of Mice ().
Mina S Young, Jackie C Kelly, Staci R Anderson, Lisa A Riffle, Stella L Spears, Joseph D Kalen

J Am Assoc Lab Anim Sci· January 2024

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Engineering CD276/B7-H3-targeted antibody-drug conjugates with enhanced cancer-eradicating capability.
Yang Feng, Jaewon Lee, Liping Yang, Mary Beth Hilton, Karen Morris, Joseph D Kalen

Cell Rep· December 2023

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Doubly Strapped Zwitterionic NIR-I and NIR-II Heptamethine Cyanine Dyes for Bioconjugation and Fluorescence Imaging.
Dong-Hao Li, Rananjaya S Gamage, Allen G Oliver, Nimit L Patel, Syed Muhammad Usama, Joseph D Kalen

Angew Chem Int Ed Engl· July 2023

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Cross-neutralizing protection of vaginal and oral mucosa from HPV challenge by vaccination in a mouse model.
Chelsea Sanders, Rebecca L Matthews, Sayyed Hamid Zarkesh Esfahani, Nazneen Khan, Nimit L Patel, Joseph D Kalen

Vaccine· July 2023

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Method To Diversify Cyanine Chromophore Functionality Enables Improved Biomolecule Tracking and Intracellular Imaging.
Syed Muhammad Usama, Sierra C Marker, Dong-Hao Li, Donald R Caldwell, Marcus Stroet, Joseph D Kalen

J Am Chem Soc· July 2023

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Modified norcyanines enable ratiometric pH imaging beyond 1000 nm.
Syed Muhammad Usama, Donald R Caldwell, Pradeep Shrestha, Michael P Luciano, Nimit L Patel, Joseph D Kalen

Biosens Bioelectron· December 2022

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3'-[F]fluoro-3'-deoxythymidine ([F]FLT) Positron Emission Tomography as an In Vivo Biomarker of inhibition of CDK 4/6-Rb pathway by Palbociclib in a patient derived bladder tumor.
James L Tatum, Joseph D Kalen, Paula M Jacobs, Lisa A Riffle, Amy James

J Transl Med· August 2022

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Growth factor dependency in mammary organoids regulates ductal morphogenesis during organ regeneration.
Sounak Sahu, Mary E Albaugh, Betty K Martin, Nimit L Patel, Lisa Riffle, Joseph D Kalen

Sci Rep· May 2022

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Cyanine Masking: A Strategy to Test Functional Group Effects on Antibody Conjugate Targeting.
Ek Raj Thapaliya, Syed Muhammad Usama, Nimit L Patel, Yang Feng, Joseph D Kalen

Bioconjug Chem· April 2022

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Targeted multicolor in vivo imaging over 1,000 nm enabled by nonamethine cyanines.
Venu G Bandi, Michael P Luciano, Mara Saccomano, Nimit L Patel, Thomas S Bischof, Joseph D Kalen

Nat Methods· March 2022

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Targeted Fluorogenic Cyanine Carbamates Enable Analysis of Antibody-Drug Conjugate Linker Chemistry.
Syed Muhammad Usama, Sierra C Marker, Donald R Caldwell, Nimit L Patel, Yang Feng, Joseph D Kalen

J Am Chem Soc· December 2021

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Design and Implementation of the Pre-Clinical DICOM Standard in Multi-Cohort Murine Studies.
Joseph D Kalen, David A Clunie, Yanling Liu, James L Tatum, Paula M Jacobs

Tomography· March 2021

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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model.
Robert Y S Cheng, Nimit L Patel, Timothy Back, Debashree Basudhar, Veena Somasundaram, Joseph D Kalen

J Vis Exp· March 2020

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A spontaneously metastatic model of bladder cancer: imaging characterization.
James L Tatum, Joseph D Kalen, Paula M Jacobs, Lilia V Ileva, Lisa A Riffle

J Transl Med· December 2019

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TFE3 Xp11.2 Translocation Renal Cell Carcinoma Mouse Model Reveals Novel Therapeutic Targets and Identifies GPNMB as a Diagnostic Marker for Human Disease.
Masaya Baba, Mitsuko Furuya, Takanobu Motoshima, Martin Lang, Shintaro Funasaki, Joseph D Kalen

Mol Cancer Res· August 2019

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A Nonaggregating Heptamethine Cyanine for Building Brighter Labeled Biomolecules.
Michael P Luciano, Stephen N Crooke, Saghar Nourian, Ivan Dingle, Roger R Nani, Joseph D Kalen

ACS Chem Biol· May 2019

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