Publications by authors named "Joseph Metzger"

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Synthetic bottlebrush block copolymer prevents disease onset in Duchenne muscular dystrophy.
Houda Cohen, Addeli Bez Batti Angulski, Joseph D Quick, Taylor S Kuebler, Brian R Thompson, Joseph M Metzger

Proc Natl Acad Sci U S A· October 2025

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Biaxial length-tension relationship in single cardiac myocytes.
Taylor M Rothermel, Houda Cohen, Anna Grosberg, Joseph M Metzger, Patrick W Alford

Biophys J· September 2025

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Elucidating cancer cachexia-mediated aberrant cardiac wasting signaling in human iPSC-derived cardiac muscle.
Nora Hosny, Houda Cohen, Mohamed Waleed Elafany, Jeff Schreifels, John Bauer, Joseph M Metzger

bioRxiv· September 2025

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North Atlantic upper ocean sound channel variations.
Gregg A Jacobs, Robert W Helber, John M Toole, E Joseph Metzger, Tommy G Jensen

J Acoust Soc Am· June 2025

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Isotopic Labeling-Enabled Chemical Proteomics Analysis Revealed Structural and Functional Features of Allysine Modifications in Mammalian Cells and Tissues.
Yi-Cheng Sin, Nora Hosny, Addeli Bez Batti Angulski, Do-Hyung Kim, Joseph M Metzger

Anal Chem· May 2025

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Gene transfer of human cardiomyopathy β-MyHC mutant R403Q directly alters intact cardiac myocyte calcium homeostasis and causes hyper-contractility.
Todd J Herron, Eric Devaney, Guadalupe Guerrero-Serna, Lakshmi Mundada, Joseph M Metzger

bioRxiv· July 2024

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Myofilament-based physiological regulatory compensation preserves diastolic function in failing hearts with severe Ca2+ handling deficits.
Frazer I Heinis, Brian R Thompson, Rishi Gulati, Matthew Wheelwright, Joseph M Metzger

JCI Insight· February 2024

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Inducing positive inotropy in human iPSC-derived cardiac muscle by gene editing-based activation of the cardiac α-myosin heavy chain.
Fikru B Bedada, Brian R Thompson, Jennifer L Mikkila, Sunny S-K Chan, Si Ho Choi, Joseph M Metzger

Sci Rep· February 2024

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Duchenne muscular dystrophy: disease mechanism and therapeutic strategies.
Addeli Bez Batti Angulski, Nora Hosny, Houda Cohen, Ashley A Martin, Dongwoo Hahn, Joseph M Metzger

Front Physiol· June 2023

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Rapid restitution of contractile dysfunction by synthetic copolymers in dystrophin-deficient single live skeletal muscle fibers.
Dongwoo Hahn, Joseph D Quick, Brian R Thompson, Adelyn Crabtree, Benjamin J Hackel, Joseph M Metzger

Skelet Muscle· May 2023

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Molecular homing and retention of muscle membrane stabilizing copolymers by non-invasive optical imaging in vivo.
Addeli Bez Batti Angulski, Houda Cohen, Mihee Kim, Dongwoo Hahn, Nicholas Van Zee, Joseph M Metzger

Mol Ther Methods Clin Dev· March 2023

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Cardiac Sarcomere Signaling in Health and Disease.
Ashley A Martin, Brian R Thompson, Dongwoo Hahn, Addeli Bez Batti Angulski, Nora Hosny, Joseph M Metzger

Int J Mol Sci· December 2022

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Sarcomere dynamics revealed by a myofilament integrated FRET-based biosensor in live skeletal muscle fibers.
Ashley A Martin, Brian R Thompson, Jonathan P Davis, Hluechy Vang, Dongwoo Hahn, Joseph M Metzger

Sci Rep· October 2022

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The road to physiological maturation of stem cell-derived cardiac muscle runs through the sarcomere.
Joseph M Metzger

J Mol Cell Cardiol· September 2022

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Cardiac myocyte intrinsic contractility and calcium handling deficits underlie heart organ dysfunction in murine cancer cachexia.
Michelle L Law, Joseph M Metzger

Sci Rep· December 2021

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Oxidative stress pathogenically remodels the cardiac myocyte cytoskeleton via structural alterations to the microtubule lattice.
Rebecca R Goldblum, Mark McClellan, Kyle White, Samuel J Gonzalez, Brian R Thompson, Joseph M Metzger

Dev Cell· August 2021

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Soluble guanylate cyclase stimulators for the treatment of hypertension: Discovery of MK-2947.
Linda Brockunier, John Stelmach, Jian Guo, Tracy Spencer, Keith Rosauer, Joseph Metzger

Bioorg Med Chem Lett· November 2020

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Advancing physiological maturation in human induced pluripotent stem cell-derived cardiac muscle by gene editing an inducible adult troponin isoform switch.
Matthew Wheelwright, Jennifer Mikkila, Fikru B Bedada, Mohammad A Mandegar, Brian R Thompson, Joseph M Metzger

Stem Cells· October 2020

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Sarcomere integrated biosensor detects myofilament-activating ligands in real time during twitch contractions in live cardiac muscle.
Anthony D Vetter, Ashley A Martin, Brian R Thompson, David D Thomas, Joseph M Metzger

J Mol Cell Cardiol· October 2020

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Investigations of an inducible intact dystrophin gene excision system in cardiac and skeletal muscle in vivo.
Addeli Bez Batti Angulski, John Bauer, Houda Cohen, Kazuhiro Kobuke, Kevin P Campbell, Joseph M Metzger

Sci Rep· July 2020

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Social stress is lethal in the mdx model of Duchenne muscular dystrophy.
Maria Razzoli, Angus Lindsay, Michelle L Law, Christopher M Chamberlain, William M Southern, Joseph M Metzger

EBioMedicine· May 2020

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Spatial Distribution of PEO-PPO-PEO Block Copolymer and PEO Homopolymer in Lipid Bilayers.
Mihee Kim, Frank Heinrich, Greg Haugstad, Guichuan Yu, Guangcui Yuan, Joseph M Metzger

Langmuir· April 2020

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Influence of the Headgroup on the Interaction of Poly(ethylene oxide)-Poly(propylene oxide) Block Copolymers with Lipid Bilayers.
Wenjia Zhang, Joseph M Metzger, Benjamin J Hackel, Frank S Bates, Timothy P Lodge

J Phys Chem B· March 2020

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Dysregulation of Calcium Handling in Duchenne Muscular Dystrophy-Associated Dilated Cardiomyopathy: Mechanisms and Experimental Therapeutic Strategies.
Michelle L Law, Houda Cohen, Ashley A Martin, Addeli Bez Batti Angulski, Joseph M Metzger

J Clin Med· February 2020

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Polar Ocean Observations: A Critical Gap in the Observing System and Its Effect on Environmental Predictions From Hours to a Season.
Gregory C Smith, Richard Allard, Marcel Babin, Laurent Bertino, Matthieu Chevallier, E Joseph Metzger

Front Mar Sci· August 2019

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