Publications by authors named "Joseph R Walker"

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PON1 Q192R genetic variant and response to clopidogrel and prasugrel: pharmacokinetics, pharmacodynamics, and a meta-analysis of clinical outcomes.
Jessica L Mega, Sandra L Close, Stephen D Wiviott, Michael Man, Suman Duvvuru, Joseph R Walker

J Thromb Thrombolysis· April 2016

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Genetics and the clinical response to warfarin and edoxaban: findings from the randomised, double-blind ENGAGE AF-TIMI 48 trial.
Jessica L Mega, Joseph R Walker, Christian T Ruff, Alexander G Vandell, Francesco Nordio

Lancet· June 2015

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Clopidogrel metaboliser status based on point-of-care CYP2C19 genetic testing in patients with coronary artery disease.
David Erlinge, Stefan James, Suman Duvvuru, Joseph A Jakubowski, Henrik Wagner, Joseph R Walker

Thromb Haemost· May 2014

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Enhanced active metabolite generation and platelet inhibition with prasugrel compared to clopidogrel regardless of genotype in thienopyridine metabolic pathways.
Oscar Ö Braun, Dominick J Angiolillo, Jose L Ferreiro, Joseph A Jakubowski, Kenneth J Winters, Joseph R Walker

Thromb Haemost· December 2013

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Population pharmacokinetic model for a novel oral hypoglycemic formed in vivo: comparing the use of active metabolite data alone versus using data of upstream and downstream metabolites.
Helen Kastrissios, Joseph R Walker, Timothy J Carrothers, Smita Kshirsagar, Tatiana Khariton

J Clin Pharmacol· March 2012

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Pharmacokinetics and pharmacodynamics following maintenance doses of prasugrel and clopidogrel in Chinese carriers of CYP2C19 variants.
Ronan P Kelly, Sandra L Close, Nagy A Farid, Kenneth J Winters, Lei Shen, Joseph R Walker

Br J Clin Pharmacol· January 2012

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Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysis.
Jessica L Mega, Sandra L Close, Stephen D Wiviott, Lei Shen, Joseph R Walker

Lancet· October 2010

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Effect of the bile acid sequestrant colesevelam on the pharmacokinetics of pioglitazone, repaglinide, estrogen estradiol, norethindrone, levothyroxine, and glyburide.
Karen S Brown, Ingrid C Armstrong, Antonia Wang, Joseph R Walker, Robert J Noveck

J Clin Pharmacol· May 2010

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Quantitative structure-property relationships modeling to predict in vitro and in vivo binding of drugs to the bile sequestrant, colesevelam (Welchol).
Joseph R Walker, Karen Brown, Shashank Rohatagi, Mohinder S Bathala, Chao Xu

J Clin Pharmacol· October 2009

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Cytochrome P450 genetic polymorphisms and the response to prasugrel: relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes.
Jessica L Mega, Sandra L Close, Stephen D Wiviott, Lei Shen, Richard D Hockett, Joseph R Walker

Circulation· May 2009

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Cytochrome p-450 polymorphisms and response to clopidogrel.
Jessica L Mega, Sandra L Close, Stephen D Wiviott, Lei Shen, Richard D Hockett, Joseph R Walker

N Engl J Med· January 2009

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Population exposure-response modeling of metformin in patients with type 2 diabetes mellitus.
Ying Hong, Shashank Rohatagi, Bahru Habtemariam, Joseph R Walker, Sherwyn L Schwartz

J Clin Pharmacol· June 2008

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beta-Adrenergic receptor polymorphisms and responses during titration of metoprolol controlled release/extended release in heart failure.
Steven G Terra, Daniel F Pauly, Craig R Lee, J Herbert Patterson, Kirkwood F Adams, Joseph R Walker

Clin Pharmacol Ther· March 2005

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Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or efficacy in hypertension.
Issam Zineh, Amber L Beitelshees, Andrea Gaedigk, Joseph R Walker, Daniel F Pauly

Clin Pharmacol Ther· December 2004

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