Publications by authors named "Joseph Rahuel"

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Embryonic stem cell-derived neurons as a cellular system to study gene function: lack of amyloid precursor proteins APP and APLP2 leads to defective synaptic transmission.
Katrin Schrenk-Siemens, Siro Perez-Alcala, Jens Richter, Emmanuel Lacroix, Joseph Rahuel

Stem Cells· August 2008

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Novel 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamide transition state peptidomimetics are potent and orally active inhibitors of human renin.
Richard Göschke, Stefan Stutz, Vittorio Rasetti, Nissim-Claude Cohen, Joseph Rahuel

J Med Chem· October 2007

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Structural modification of the P2' position of 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamides: the discovery of aliskiren, a potent nonpeptide human renin inhibitor active after once daily dosing in marmosets.
Jürgen Maibaum, Stefan Stutz, Richard Göschke, Pascal Rigollier, Yasuchika Yamaguchi, Joseph Rahuel

J Med Chem· October 2007

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Structure-based design of aliskiren, a novel orally effective renin inhibitor.
Jeanette M Wood, Jürgen Maibaum, Joseph Rahuel, Markus G Grütter, Nissim-Claude Cohen

Biochem Biophys Res Commun· September 2003

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