Publications by authors named "Pascal Rigollier"

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JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRAS for the Treatment of Solid Tumors.
Edwige Lorthiois, Marc Gerspacher, Kim S Beyer, Andrea Vaupel, Catherine Leblanc, Pascal Rigollier

J Med Chem· December 2022

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Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C.
Andreas Weiss, Edwige Lorthiois, Louise Barys, Kim S Beyer, Claudio Bomio-Confaglia, Pascal Rigollier

Cancer Discov· June 2022

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Discovery of Orally Active Hydroxyethylamine Based SPPL2a Inhibitors.
Juraj Velcicky, Casey J N Mathison, Victor Nikulin, Daniel Pflieger, Robert Epple, Pascal Rigollier

ACS Med Chem Lett· June 2019

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Discovery of the First Potent, Selective, and Orally Bioavailable Signal Peptide Peptidase-Like 2a (SPPL2a) Inhibitor Displaying Pronounced Immunomodulatory Effects In Vivo.
Juraj Velcicky, Ursula Bodendorf, Pascal Rigollier, Robert Epple, Daniel R Beisner

J Med Chem· February 2018

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Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39.
Frederic Bassilana, Adam Carlson, Jennifer A DaSilva, Bianka Grosshans, Solange Vidal, Pascal Rigollier

Nat Chem Biol· May 2014

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Fragment-based screening by biochemical assays: Systematic feasibility studies with trypsin and MMP12.
Andreas Boettcher, Simon Ruedisser, Paulus Erbel, Daniela Vinzenz, Nikolaus Schiering, Pascal Rigollier

J Biomol Screen· October 2010

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Novel 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamide transition state peptidomimetics are potent and orally active inhibitors of human renin.
Richard Göschke, Stefan Stutz, Vittorio Rasetti, Nissim-Claude Cohen, Joseph Rahuel, Pascal Rigollier

J Med Chem· October 2007

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Structural modification of the P2' position of 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamides: the discovery of aliskiren, a potent nonpeptide human renin inhibitor active after once daily dosing in marmosets.
Jürgen Maibaum, Stefan Stutz, Richard Göschke, Pascal Rigollier, Yasuchika Yamaguchi

J Med Chem· October 2007

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Key aspects of the Novartis compound collection enhancement project for the compilation of a comprehensive chemogenomics drug discovery screening collection.
Edgar Jacoby, Ansgar Schuffenhauer, Maxim Popov, Kamal Azzaoui, Benjamin Havill, Pascal Rigollier

Curr Top Med Chem· June 2005

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Discovery and SAR of potent, orally available and brain-penetrable 5,6-dihydro-4H-3-thia-1-aza-benzo[e]azulen- and 4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen derivatives as neuropeptide Y Y5 receptor antagonists.
Heinrich Rueeger, Marc Gerspacher, Peter Buehlmayer, Pascal Rigollier, Yasuchika Yamaguchi

Bioorg Med Chem Lett· May 2004

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Structure-based design of aliskiren, a novel orally effective renin inhibitor.
Jeanette M Wood, Jürgen Maibaum, Joseph Rahuel, Markus G Grütter, Nissim-Claude Cohen, Pascal Rigollier

Biochem Biophys Res Commun· September 2003

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