Publications by authors named "Joseph Roitelman"

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Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis.
Anke Loregger, Matthijs Raaben, Josephine Tan, Saskia Scheij, Martina Moeton, Joseph Roitelman

Arterioscler Thromb Vasc Biol· November 2017

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Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system.
Yien Che Tsai, Gil S Leichner, Margaret M P Pearce, Gaye Lynn Wilson, Richard J H Wojcikiewicz, Joseph Roitelman

Mol Biol Cell· December 2012

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Metabolically regulated endoplasmic reticulum-associated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase: evidence for requirement of a geranylgeranylated protein.
Gil S Leichner, Rachel Avner, Dror Harats, Joseph Roitelman

J Biol Chem· September 2011

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SPFH1 and SPFH2 mediate the ubiquitination and degradation of inositol 1,4,5-trisphosphate receptors in muscarinic receptor-expressing HeLa cells.
Yuan Wang, Margaret M P Pearce, Danielle A Sliter, James A Olzmann, John C Christianson, Joseph Roitelman

Biochim Biophys Acta· November 2009

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Dislocation of HMG-CoA reductase and Insig-1, two polytopic endoplasmic reticulum proteins, en route to proteasomal degradation.
Gil S Leichner, Rachel Avner, Dror Harats, Joseph Roitelman

Mol Biol Cell· July 2009

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The low-density lipoprotein receptor plays a role in the infection of primary human hepatocytes by hepatitis C virus.
Sonia Molina, Valérie Castet, Chantal Fournier-Wirth, Lydiane Pichard-Garcia, Rachel Avner, Joseph Roitelman

J Hepatol· March 2007

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Ubiquitin is conjugated by membrane ubiquitin ligase to three sites, including the N terminus, in transmembrane region of mammalian 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for sterol-regulated enzyme degradation.
Ram Doolman, Gil S Leichner, Rachel Avner, Joseph Roitelman

J Biol Chem· September 2004

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Apomine, a novel hypocholesterolemic agent, accelerates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and stimulates low density lipoprotein receptor activity.
Joseph Roitelman, Danièle Masson, Rachel Avner, Corinne Ammon-Zufferey, Anne Perez

J Biol Chem· February 2004

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Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum.
Marjolein Kikkert, Ram Doolman, Min Dai, Rachel Avner, Gerco Hassink, Joseph Roitelman

J Biol Chem· January 2004

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Lovastatin and phospholipase Cgamma regulate constitutive and protein kinase C dependent integrin mediated interactions of human T-cells with collagen.
Ilan Bank, Alexander Koltakov, Eva Nir-Glickman, Itamar Goldstein, JianFeng Li, Joseph Roitelman

Cell Immunol· May 2003

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