Publications by authors named "Joshua Close"

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Discovery of MK-8318, a Potent and Selective CRTh2 Receptor Antagonist for the Treatment of Asthma.
Xianhai Huang, Jason Brubaker, Wei Zhou, Purakkattle J Biju, Li Xiao, Joshua Close

ACS Med Chem Lett· July 2018

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The Discovery of 3-((4-Chloro-3-methoxyphenyl)amino)-1-((3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl)-1H-pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties.
Tony Siu, Jason Brubaker, Peter Fuller, Luis Torres, Hongbo Zeng, Joshua Close

J Med Chem· December 2017

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Divergent kinetics differentiate the mechanism of action of two HDAC inhibitors.
Astrid M Kral, Nicole Ozerova, Joshua Close, Joon Jung, Melissa Chenard

Biochemistry· February 2014

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Lead optimization of 4,4-biaryl piperidine amides as γ-secretase inhibitors.
Joshua Close, Richard Heidebrecht, John Hendrix, Chaomin Li, Ben Munoz

Bioorg Med Chem Lett· May 2012

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Exploring the pharmacokinetic properties of phosphorus-containing selective HDAC 1 and 2 inhibitors (SHI-1:2).
Richard W Heidebrecht, Melissa Chenard, Joshua Close, William K Dahlberg, Judith Fleming

Bioorg Med Chem Lett· April 2009

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Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2).
Joey L Methot, Prasun K Chakravarty, Melissa Chenard, Joshua Close, Jonathan C Cruz

Bioorg Med Chem Lett· February 2008

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