Publications by authors named "Jonathan C Cruz"

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Discovery of novel triazolobenzazepinones as γ-secretase modulators with central Aβ42 lowering in rodents and rhesus monkeys.
Christian Fischer, Susan L Zultanski, Hua Zhou, Joey L Methot, Sanjiv Shah, Jonathan C Cruz

Bioorg Med Chem Lett· September 2015

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Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor.
Joey L Methot, Dawn Mampreian Hoffman, David J Witter, Matthew G Stanton, Paul Harrington, Jonathan C Cruz

ACS Med Chem Lett· April 2014

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Triazoles as γ-secretase modulators.
Christian Fischer, Susan L Zultanski, Hua Zhou, Joey L Methot, W Colby Brown, Jonathan C Cruz

Bioorg Med Chem Lett· July 2011

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Purine derivatives as potent gamma-secretase modulators.
Alexey Rivkin, Sean P Ahearn, Stephanie M Chichetti, Christopher L Hamblett, Yudith Garcia, Jonathan C Cruz

Bioorg Med Chem Lett· April 2010

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Fluorinated piperidine acetic acids as gamma-secretase modulators.
Matthew G Stanton, Jed Hubbs, David Sloman, Christopher Hamblett, Paula Andrade, Jonathan C Cruz

Bioorg Med Chem Lett· January 2010

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Histone deacetylase inhibitors with a primary amide zinc binding group display antitumor activity in xenograft model.
Barbara Attenni, Jesus M Ontoria, Jonathan C Cruz, Michael Rowley, Carsten Schultz-Fademrecht

Bioorg Med Chem Lett· June 2009

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Parallel medicinal chemistry approaches to selective HDAC1/HDAC2 inhibitor (SHI-1:2) optimization.
Solomon D Kattar, Laura M Surdi, Anna Zabierek, Joey L Methot, Richard E Middleton, Jonathan C Cruz

Bioorg Med Chem Lett· February 2009

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SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2).
Joey L Methot, Christopher L Hamblett, Dawn M Mampreian, Joon Jung, Andreas Harsch, Jonathan C Cruz

Bioorg Med Chem Lett· December 2008

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Quantitative analysis of histone deacetylase-1 selective histone modifications by differential mass spectrometry.
Anita Y H Lee, Cloud P Paweletz, Roy M Pollock, Robert E Settlage, Jonathan C Cruz

J Proteome Res· December 2008

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Phenylglycine and phenylalanine derivatives as potent and selective HDAC1 inhibitors (SHI-1).
Kevin J Wilson, David J Witter, Jonathan B Grimm, Phieng Siliphaivanh, Karin M Otte, Jonathan C Cruz

Bioorg Med Chem Lett· March 2008

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Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2).
Joey L Methot, Prasun K Chakravarty, Melissa Chenard, Joshua Close, Jonathan C Cruz

Bioorg Med Chem Lett· February 2008

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The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors.
Christopher L Hamblett, Joey L Methot, Dawn M Mampreian, David L Sloman, Matthew G Stanton, Jonathan C Cruz

Bioorg Med Chem Lett· October 2007

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p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo.
Jonathan C Cruz, Dohoon Kim, Lily Y Moy, Matthew M Dobbin, Xiaoyan Sun

J Neurosci· October 2006

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Niemann-Pick type C disease and intracellular cholesterol trafficking.
Ta-Yuan Chang, Patrick C Reid, Shigeki Sugii, Nobutaka Ohgami, Jonathan C Cruz

J Biol Chem· June 2005

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Cdk5 deregulation in the pathogenesis of Alzheimer's disease.
Jonathan C Cruz, Li-Huei Tsai

Trends Mol Med· September 2004

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A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease.
Jonathan C Cruz, Li-Huei Tsai

Curr Opin Neurobiol· June 2004

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Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles.
Jonathan C Cruz, Huang-Chun Tseng, Joseph A Goldman, Heather Shih, Li-Huei Tsai

Neuron· October 2003

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Synthesis and biochemical properties of a new photoactivatable cholesterol analog 7,7-azocholestanol and its linoleate ester in Chinese hamster ovary cell lines.
Jonathan C Cruz, Matthew Thomas, Edmund Wong, Nobutaka Ohgami, Shigeki Sugii

J Lipid Res· August 2002

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