Publications by authors named "Jed Hubbs"

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Non-muscle myosin II inhibition at the site of axon injury increases axon regeneration.
Keunjung Heo, Tammy Szu-Yu Ho, Xiangsunze Zeng, Bruna Lenfers Turnes, Maryam Arab, Jed Hubbs

Nat Commun· March 2025

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ALDH5A1-deficient iPSC-derived excitatory and inhibitory neurons display cell type specific alterations.
Wardiya Afshar-Saber, Nicole A Teaney, Kellen D Winden, Hellen Jumo, Xutong Shi, Jed Hubbs

Neurobiol Dis· January 2024

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High-content screening identifies a small molecule that restores AP-4-dependent protein trafficking in neuronal models of AP-4-associated hereditary spastic paraplegia.
Afshin Saffari, Barbara Brechmann, Cedric Böger, Wardiya Afshar Saber, Hellen Jumo, Jed Hubbs

Nat Commun· January 2024

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High-Content Small Molecule Screen Identifies a Novel Compound That Restores AP-4-Dependent Protein Trafficking in Neuronal Models of AP-4-Associated Hereditary Spastic Paraplegia.
Afshin Saffari, Barbara Brechmann, Cedric Boeger, Wardiya Afshar Saber, Hellen Jumo, Jed Hubbs

Res Sq· June 2023

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Itch suppression in mice and dogs by modulation of spinal α2 and α3GABA receptors.
William T Ralvenius, Elena Neumann, Martina Pagani, Mario A Acuña, Hendrik Wildner, Jed Lee Hubbs

Nat Commun· August 2018

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Minimization of drug-drug interaction risk and candidate selection in a natural product-based class of gamma-secretase modulators.
Jed L Hubbs, Nathan O Fuller, Wesley F Austin, Ruichao Shen, Jianguo Ma

Bioorg Med Chem Lett· April 2015

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Efficacy of SPI-1865, a novel gamma-secretase modulator, in multiple rodent models.
Robyn M Loureiro, Jo Ann Dumin, Timothy D McKee, Wesley F Austin, Nathan O Fuller, Jed L Hubbs

Alzheimers Res Ther· May 2014

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Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor.
Joey L Methot, Dawn Mampreian Hoffman, David J Witter, Matthew G Stanton, Paul Harrington, Jed Hubbs

ACS Med Chem Lett· April 2014

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Modulation of gamma-secretase for the treatment of Alzheimer's disease.
Barbara Tate, Timothy D McKee, Robyn M B Loureiro, Jo Ann Dumin, Weiming Xia, Jed L Hubbs

Int J Alzheimers Dis· January 2013

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Optimization of a natural product-based class of γ-secretase modulators.
Jed L Hubbs, Nathan O Fuller, Wesley F Austin, Ruichao Shen, Steffen P Creaser

J Med Chem· November 2012

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Initial Optimization of a New Series of γ-Secretase Modulators Derived from a Triterpene Glycoside.
Nathan O Fuller, Jed L Hubbs, Wesley F Austin, Steffen P Creaser, Timothy D McKee

ACS Med Chem Lett· November 2012

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Purine derivatives as potent gamma-secretase modulators.
Alexey Rivkin, Sean P Ahearn, Stephanie M Chichetti, Christopher L Hamblett, Yudith Garcia, Jed L Hubbs

Bioorg Med Chem Lett· April 2010

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Fluorinated piperidine acetic acids as gamma-secretase modulators.
Matthew G Stanton, Jed Hubbs, David Sloman, Christopher Hamblett, Paula Andrade

Bioorg Med Chem Lett· January 2010

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Amino acid derivatives as histone deacetylase inhibitors.
Jed L Hubbs, Hua Zhou, Astrid M Kral, Judith C Fleming, William K Dahlberg

Bioorg Med Chem Lett· January 2008

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A second-generation synthesis of the C1-C28 portion of the altohyrtins (spongistatins).
Jed L Hubbs, Clayton H Heathcock

J Am Chem Soc· October 2003

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Multigram synthesis of the C29-C51 subunit and completion of the total synthesis of altohyrtin C (spongistatin 2).
Clayton H Heathcock, Mark McLaughlin, Jesus Medina, Jed L Hubbs, Grier A Wallace

J Am Chem Soc· October 2003

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Ni(II) bis(oxazoline)-catalyzed enantioselective syn aldol reactions of N-propionylthiazolidinethiones in the presence of silyl triflates.
David A Evans, C Wade Downey, Jed L Hubbs

J Am Chem Soc· July 2003

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