Publications by authors named "Joshua D Noe"

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Hybrid Population Pharmacokinetic-Machine Learning Modeling to Predict Infliximab Pharmacokinetics in Pediatric and Young Adult Patients with Crohn's Disease.
Kei Irie, Phillip Minar, Jack Reifenberg, Brendan M Boyle, Joshua D Noe

Clin Pharmacokinet· November 2025

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Model-Informed Deep Q-Networks to Guide Infliximab Dosing in Pediatric Crohn's Disease.
Kei Irie, Phillip Minar, Jack Reifenberg, Brendan M Boyle, Joshua D Noe

Clin Pharmacol Ther· November 2025

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Model-informed Deep Q-Networks to Guide Infliximab Dosing in Pediatric Crohn's Disease.
Kei Irie, Phillip Minar, Jack Reifenberg, Brendan M Boyle, Joshua D Noe

bioRxiv· July 2025

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Machine Learning Modeling for Predicting Infliximab Pharmacokinetics in Pediatric and Young Adult Patients With Crohn Disease: Leveraging Ensemble Modeling With Synthetic and Real-World Data.
Kei Irie, Phillip Minar, Jack Reifenberg, Brendan M Boyle, Joshua D Noe

Ther Drug Monit· June 2025

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Hybrid Population PK-Machine Learning Modeling to Predict Infliximab Pharmacokinetics in Pediatric and Young Adult Patients with Crohn's Disease.
Kei Irie, Phillip Minar, Jack Reifenberg, Brendan M Boyle, Joshua D Noe

bioRxiv· May 2025

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Progression of Pediatric Crohn's Disease Is Associated With Anti-Tumor Necrosis Factor Timing and Body Mass Index Z-Score Normalization.
Duke Geem, David Hercules, Ranjit S Pelia, Suresh Venkateswaran, Anne Griffiths, Joshua D Noe

Clin Gastroenterol Hepatol· February 2024

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Exome Sequencing Implicates DGKZ , ESRRA , and GXYLT1 for Modulating Granuloma Formation in Crohn Disease.
R Alan Harris, Allyson H Bush, Todd N Eagar, Justin Qian, Michael P Greenwood, Joshua D Noe

J Pediatr Gastroenterol Nutr· September 2023

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Real world population pharmacokinetic study in children and young adults with inflammatory bowel disease discovers novel blood and stool microbial predictors of vedolizumab clearance.
Ruben J Colman, Tomoyuki Mizuno, Keizo Fukushima, David B Haslam, Jeffrey S Hyams, Joshua D Noe

Aliment Pharmacol Ther· March 2023

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Antibodies-to-infliximab accelerate clearance while dose intensification reverses immunogenicity and recaptures clinical response in paediatric Crohn's disease.
Ruben J Colman, Ye Xiong, Tomoyuki Mizuno, Jeffrey S Hyams, Joshua D Noe

Aliment Pharmacol Ther· March 2022

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Stratification of risk of progression to colectomy in ulcerative colitis via measured and predicted gene expression.
Angela Mo, Sini Nagpal, Kyle Gettler, Talin Haritunians, Mamta Giri, Joshua D Noe

Am J Hum Genet· September 2021

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Achieving Target Infliximab Drug Concentrations Improves Blood and Fecal Neutrophil Biomarkers in Crohn's Disease.
Ruben J Colman, Yi-Ting Tsai, Kimberly Jackson, Brendan M Boyle, Joshua D Noe

Inflamm Bowel Dis· June 2021

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Real-World Infliximab Pharmacokinetic Study Informs an Electronic Health Record-Embedded Dashboard to Guide Precision Dosing in Children with Crohn's Disease.
Ye Xiong, Tomoyuki Mizuno, Ruben Colman, Jeffrey Hyams, Joshua D Noe

Clin Pharmacol Ther· June 2021

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Mucosal Inflammatory and Wound Healing Gene Programs Reveal Targets for Stricturing Behavior in Pediatric Crohn's Disease.
Yael Haberman, Phillip Minar, Rebekah Karns, Phillip J Dexheimer, Sudhir Ghandikota, Joshua D Noe

J Crohns Colitis· February 2021

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Prioritizing Crohn's disease genes by integrating association signals with gene expression implicates monocyte subsets.
Kyle Gettler, Mamta Giri, Ephraim Kenigsberg, Jerome Martin, Ling-Shiang Chuang, Joshua D Noe

Genes Immun· September 2019

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Variation in Care in the Management of Children With Crohn's Disease: Data From a Multicenter Inception Cohort Study.
Chenthan Krishnakumar, Cortney R Ballengee, Chunyan Liu, Mi-Ok Kim, Susan S Baker, Joshua D Noe

Inflamm Bowel Dis· June 2019

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Blood-Derived DNA Methylation Signatures of Crohn's Disease and Severity of Intestinal Inflammation.
Hari K Somineni, Suresh Venkateswaran, Varun Kilaru, Urko M Marigorta, Angela Mo, Joshua D Noe

Gastroenterology· June 2019

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Serum Protein Biomarkers of Fibrosis Aid in Risk Stratification of Future Stricturing Complications in Pediatric Crohn's Disease.
Jing Wu, David M Lubman, Subra Kugathasan, Lee A Denson, Jeffrey S Hyams, Joshua D Noe

Am J Gastroenterol· May 2019

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Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis.
Yael Haberman, Melanie Schirmer, Phillip J Dexheimer, Rebekah Karns, Tzipi Braun, Joshua D Noe

Mucosal Immunol· March 2019

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Genetic variants and pathways implicated in a pediatric inflammatory bowel disease cohort.
Kelly A Shaw, David J Cutler, David Okou, Anne Dodd, Bruce J Aronow, Joshua D Noe

Genes Immun· February 2019

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Genetic and Transcriptomic Variation Linked to Neutrophil Granulocyte-Macrophage Colony-Stimulating Factor Signaling in Pediatric Crohn's Disease.
Lee A Denson, Ingrid Jurickova, Rebekah Karns, Kelly A Shaw, David J Cutler, Joshua D Noe

Inflamm Bowel Dis· February 2019

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Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response.
Yael Haberman, Rebekah Karns, Phillip J Dexheimer, Melanie Schirmer, Judith Somekh, Joshua D Noe

Nat Commun· January 2019

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The Effect of Early-Life Environmental Exposures on Disease Phenotype and Clinical Course of Crohn's Disease in Children.
Livia Lindoso, Kajari Mondal, Suresh Venkateswaran, Hari K Somineni, Cortney Ballengee, Joshua D Noe

Am J Gastroenterol· October 2018

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Evolution of Pediatric Inflammatory Bowel Disease Unclassified (IBD-U): Incorporated With Serological and Gene Expression Profiles.
Raguraj Chandradevan, Tatyana Hofmekler, Kajari Mondal, Nusrat Harun, Suresh Venkateswaran, Joshua D Noe

Inflamm Bowel Dis· September 2018

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Serologic Reactivity Reflects Clinical Expression of Ulcerative Colitis in Children.
Elizabeth A Spencer, Sonia M Davis, David R Mack, Brendan M Boyle, Anne M Griffiths, Joshua D Noe

Inflamm Bowel Dis· May 2018

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Moving On: Transition Readiness in Adolescents and Young Adults With IBD.
Amitha Prasad Gumidyala, Rachel N Greenley, Jill M Plevinsky, Natasha Poulopoulos, Jose Cabrera, Joshua D Noe

Inflamm Bowel Dis· February 2018

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