Publications by authors named "Joshua Pacheco"

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Galactosylsphingosine does not interfere with the quantitation of plasma glucosylsphingosine levels in Gaucher patients.
Wei-Lien Chuang, Joshua Pacheco, Dritan Hoxha, Gerard Sanderink, Crystal Sung

Clin Chim Acta· July 2019

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Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease.
Yumiko V Taguchi, Jun Liu, Jiapeng Ruan, Joshua Pacheco, Xiaokui Zhang

J Neurosci· October 2017

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A Simple, High-Throughput Method for Analysis of Ceramide, Glucosylceramide, and Ceramide Trihexoside in Dried Blood Spots by LC/MS/MS.
Wei-Lien Chuang, Joshua Pacheco, Kate Zhang

Methods Mol Biol· September 2016

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Glycosphingolipids are modulators of disease pathogenesis in amyotrophic lateral sclerosis.
James C Dodge, Christopher M Treleaven, Joshua Pacheco, Samantha Cooper, Channa Bao

Proc Natl Acad Sci U S A· June 2015

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Improved sensitivity of an acid sphingomyelinase activity assay using a C6:0 sphingomyelin substrate.
Wei-Lien Chuang, Joshua Pacheco, Samantha Cooper, Jonathan S Kingsbury, John Hinds

Mol Genet Metab Rep· June 2015

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Nonclinical safety assessment of recombinant human acid sphingomyelinase (rhASM) for the treatment of acid sphingomyelinase deficiency:the utility of animal models of disease in the toxicological evaluation of potential therapeutics.
James M Murray, Anne Marie Thompson, Allison Vitsky, Michael Hawes, Wei-Lien Chuang, Joshua Pacheco

Mol Genet Metab· February 2015

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Synthesis of terephthalic acid via Diels-Alder reactions with ethylene and oxidized variants of 5-hydroxymethylfurfural.
Joshua J Pacheco, Mark E Davis

Proc Natl Acad Sci U S A· June 2014

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Lyso-sphingomyelin is elevated in dried blood spots of Niemann-Pick B patients.
Wei-Lien Chuang, Joshua Pacheco, Samantha Cooper, Margaret M McGovern, Gerald F Cox

Mol Genet Metab· February 2014

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Iminosugar-based inhibitors of glucosylceramide synthase prolong survival but paradoxically increase brain glucosylceramide levels in Niemann-Pick C mice.
Jennifer B Nietupski, Joshua J Pacheco, Wei-Lien Chuang, Kimberly Maratea, Lingyun Li

Mol Genet Metab· April 2012

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Adeno-associated virus-mediated expression of acid sphingomyelinase decreases atherosclerotic lesion formation in apolipoprotein E(-/-) mice.
Andrew J Leger, Leocadia M Mosquea, Lingyun Li, Weilien Chuang, Joshua Pacheco

J Gene Med· June 2011

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The chemosensitizing activity of inhibitors of glucosylceramide synthase is mediated primarily through modulation of P-gp function.
Lilly Chai, Rajashree P McLaren, Ann Byrne, Wei-Lien Chuang, Yinyin Huang, Joshua Pacheco

Int J Oncol· March 2011

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Substrate reduction augments the efficacy of enzyme therapy in a mouse model of Fabry disease.
John Marshall, Karen M Ashe, Dinesh Bangari, KerryAnne McEachern, Wei-Lien Chuang, Joshua Pacheco

PLoS One· November 2010

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Inhibiting glycosphingolipid synthesis ameliorates hepatic steatosis in obese mice.
Hongmei Zhao, Malgorzata Przybylska, I-Huan Wu, Jinhua Zhang, Panagiotis Maniatis, Joshua Pacheco

Hepatology· July 2009

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