Publications by authors named "Joshua Rokach"

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Concise Syntheses of Microsomal Metabolites of a Potent OXE (Oxoeicosanoid) Receptor Antagonist.
Shishir Chourey, Rui Wang, Qiuji Ye, Chintam Nagendra Reddy, Shiyu Sun, Joshua Rokach

Chem Pharm Bull (Tokyo)· January 2024

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Metabolism of anti-inflammatory OXE (oxoeicosanoid) receptor antagonists by nonhuman primates.
Chantal Cossette, Shishir Chourey, Qiuji Ye, Chintam Nagendra Reddy, Rui Wang, Joshua Rokach

Eur J Pharm Sci· May 2022

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Targeting the OXE receptor with a selective antagonist inhibits allergen-induced pulmonary inflammation in non-human primates.
Chantal Cossette, Lisa A Miller, Qiuji Ye, Shishir Chourey, Chintam Nagendra Reddy, Joshua Rokach

Br J Pharmacol· January 2022

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Targeting the OXE receptor as a potential novel therapy for asthma.
William S Powell, Joshua Rokach

Biochem Pharmacol· September 2020

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Inhibition of allergen-induced dermal eosinophilia by an oxoeicosanoid receptor antagonist in non-human primates.
Lisa A Miller, Chantal Cossette, Shishir Chourey, Qiuji Ye, Chintam Nagendra Reddy, Joshua Rokach

Br J Pharmacol· January 2020

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Novel highly potent OXE receptor antagonists with prolonged plasma lifetimes that are converted to active metabolites in vivo in monkeys.
Qiuji Ye, Shishir Chourey, Chintam Nagendra Reddy, Rui Wang, Chantal Cossette, Joshua Rokach

Br J Pharmacol· January 2020

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Corrigendum to "In vivo α-hydroxylation of a 2-alkylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid in monkeys" [Biochem. Pharmacol. 138 (2017) 107-118].
Shishir Chourey, Qiuji Ye, Chintam Nagendra Reddy, Chantal Cossette, Sylvie Gravel, Joshua Rokach

Biochem Pharmacol· August 2018

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Novel Highly Potent and Metabolically Resistant Oxoeicosanoid (OXE) Receptor Antagonists That Block the Actions of the Granulocyte Chemoattractant 5-Oxo-6,8,11,14-Eicosatetraenoic Acid (5-oxo-ETE).
Shishir Chourey, Qiuji Ye, Chintam Nagendra Reddy, Rui Wang, Chantal Cossette, Joshua Rokach

J Med Chem· July 2018

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Metabolism and pharmacokinetics of a potent N-acylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) in rats and monkeys.
Chintam Nagendra Reddy, Hussam Alhamza, Shishir Chourey, Qiuji Ye, Vivek Gore, Joshua Rokach

Eur J Pharm Sci· March 2018

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Structure-activity relationship study of β-oxidation resistant indole-based 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) receptor antagonists.
Qiuji Ye, Shishir Chourey, Rui Wang, Nagendra Reddy Chintam, Sylvie Gravel, Joshua Rokach

Bioorg Med Chem Lett· October 2017

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In vivo α-hydroxylation of a 2-alkylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid in monkeys.
Shishir Chourey, Qiuji Ye, Chintam Nagendra Reddy, Chantal Cossette, Sylvie Gravel, Joshua Rokach

Biochem Pharmacol· August 2017

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Design and synthesis of affinity chromatography ligands for the purification of 5-hydroxyeicosanoid dehydrogenase.
Chintam Nagendra Reddy, Qiuji Ye, Pranav Patel, Sashikala Sivendran, Shishir Chourey, Joshua Rokach

Bioorg Med Chem· January 2017

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Pharmacokinetics and Metabolism of Selective Oxoeicosanoid (OXE) Receptor Antagonists and Their Effects on 5-Oxo-6,8,11,14-eicosatetraenoic Acid (5-Oxo-ETE)-Induced Granulocyte Activation in Monkeys.
Chantal Cossette, Shishir Chourey, Qiuji Ye, Chintam Nagendra Reddy, Vivek Gore, Joshua Rokach

J Med Chem· November 2016

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Biosynthesis and actions of 5-oxoeicosatetraenoic acid (5-oxo-ETE) on feline granulocytes.
Chantal Cossette, Sylvie Gravel, Chintam Nagendra Reddy, Vivek Gore, Shishir Chourey, Joshua Rokach

Biochem Pharmacol· August 2015

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Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid.
William S Powell, Joshua Rokach

Biochim Biophys Acta· April 2015

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Base-dependent formation of cis and trans olefins and their application in the synthesis of 5-oxo-ETE receptor antagonists.
Vivek Gore, Shishir Chourey, Qiuji Ye, Pranav Patel, Yannick Ouedraogo, Joshua Rokach

Bioorg Med Chem Lett· August 2014

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Two Potent OXE-R Antagonists: Assignment of Stereochemistry.
Pranav Patel, Chintam Nagendra Reddy, Vivek Gore, Shishir Chourey, Qiuji Ye, Joshua Rokach

ACS Med Chem Lett· July 2014

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Inhibition of 5-oxo-6,8,11,14-eicosatetraenoic acid-induced activation of neutrophils and eosinophils by novel indole OXE receptor antagonists.
Vivek Gore, Sylvie Gravel, Chantal Cossette, Pranav Patel, Shishir Chourey, Joshua Rokach

J Med Chem· January 2014

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The eosinophil chemoattractant 5-oxo-ETE and the OXE receptor.
William S Powell, Joshua Rokach

Prog Lipid Res· October 2013

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Quantification of lipid mediator metabolites in human urine from asthma patients by electrospray ionization mass spectrometry: controlling matrix effects.
David Balgoma, Johan Larsson, Joshua Rokach, John A Lawson, Kameran Daham

Anal Chem· August 2013

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5-Oxo-ETE receptor antagonists.
Vivek Gore, Pranav Patel, Chih-Tsung Chang, Sashikala Sivendran, Namin Kang, Joshua Rokach

J Med Chem· May 2013

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Quantification of in vivo oxidative damage in Caenorhabditis elegans during aging by endogenous F3-isoprostane measurement.
Christiaan F Labuschagne, Edwin C A Stigter, Margriet M W B Hendriks, Ruud Berger, Joshua Rokach

Aging Cell· April 2013

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Enhanced formation of 5-oxo-6,8,11,14-eicosatetraenoic acid by cancer cells in response to oxidative stress, docosahexaenoic acid and neutrophil-derived 5-hydroxy-6,8,11,14-eicosatetraenoic acid.
Gail E Grant, Stephen Rubino, Sylvie Gravel, Xiaoping Wang, Pranav Patel, Joshua Rokach

Carcinogenesis· June 2011

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5-oxo-ETE is a major oxidative stress-induced arachidonate metabolite in B lymphocytes.
Gail E Grant, Sylvie Gravel, Julie Guay, Pranav Patel, Bruce D Mazer, Joshua Rokach

Free Radic Biol Med· May 2011

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C20-trifluoro-5-oxo-ETE: a metabolically stable 5-oxo-ETE derivative.
Pranav Patel, Vivek Gore, William S Powell, Joshua Rokach

Bioorg Med Chem Lett· April 2011

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