Publications by authors named "Judith Straimer"

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Cryo-EM structures of Nipah virus polymerases and high-throughput RdRp assay development enable anti-NiV drug discovery.
Zhenhang Chen, Jeanne Quirit Dudley, Colin Deniston, Cosmo Z Buffalo, Debjani Patra, Judith Straimer

Nat Commun· July 2025

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Generation of a Transgenic Parasite Expressing Circumsporozoite Protein for Testing CSP-Based Malaria Vaccines in Non-Human Primates.
Maya Aleshnick, Shreeya Hegde, Charlie Jennison, Sebastian A Mikolajczak, Ashley M Vaughan, Judith Straimer

Vaccines (Basel)· May 2025

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A conserved metabolic signature associated with response to fast-acting anti-malarial agents.
Nelson V Simwela, W Armand Guiguemde, Judith Straimer, Clement Regnault, Barbara H Stokes

Microbiol Spectr· December 2023

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A G358S mutation in the Plasmodium falciparum Na pump PfATP4 confers clinically-relevant resistance to cipargamin.
Deyun Qiu, Jinxin V Pei, James E O Rosling, Vandana Thathy, Dongdi Li, Judith Straimer

Nat Commun· September 2022

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Efficacy of Cipargamin (KAE609) in a Randomized, Phase II Dose-Escalation Study in Adults in Sub-Saharan Africa With Uncomplicated Plasmodium falciparum Malaria.
Esther K Schmitt, Gilles Ndayisaba, Adoke Yeka, Kwaku Poku Asante, Martin P Grobusch, Judith Straimer

Clin Infect Dis· May 2022

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High Prevalence of Plasmodium falciparum K13 Mutations in Rwanda Is Associated With Slow Parasite Clearance After Treatment With Artemether-Lumefantrine.
Judith Straimer, Preetam Gandhi, Katalin Csermak Renner, Esther K Schmitt

J Infect Dis· April 2022

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Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria.
Benjamin R Taft, Fumiaki Yokokawa, Tom Kirrane, Anne-Catherine Mata, Richard Huang, Judith Straimer

J Med Chem· March 2022

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K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness.
Barbara H Stokes, Satish K Dhingra, Kelly Rubiano, Sachel Mok, Judith Straimer

Elife· July 2021

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Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13.
Nina F Gnädig, Barbara H Stokes, Rachel L Edwards, Gavreel F Kalantarov, Kim C Heimsch, Judith Straimer

PLoS Pathog· April 2020

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Generation of Transmission-Competent Human Malaria Parasites with Chromosomally-Integrated Fluorescent Reporters.
Kyle Jarrod McLean, Judith Straimer, Christine S Hopp, Joel Vega-Rodriguez, Jennifer L Small-Saunders

Sci Rep· September 2019

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Artemisinin resistance phenotypes and K13 inheritance in a cross and model.
Juliana M Sá, Sarah R Kaslow, Michael A Krause, Viviana A Melendez-Muniz, Rebecca E Salzman, Judith Straimer

Proc Natl Acad Sci U S A· December 2018

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A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance.
Paul M O'Neill, Richard K Amewu, Susan A Charman, Sunil Sabbani, Nina F Gnädig, Judith Straimer

Nat Commun· May 2017

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K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness .
Judith Straimer, Nina F Gnädig, Barbara H Stokes, Michelle Ehrenberger, Audrey A Crane

mBio· April 2017

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Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling.
Amélie Le Bihan, Ruben de Kanter, Iñigo Angulo-Barturen, Christoph Binkert, Christoph Boss, Judith Straimer

PLoS Med· October 2016

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Artemisinin Action and Resistance in Plasmodium falciparum.
Leann Tilley, Judith Straimer, Nina F Gnädig, Stuart A Ralph, David A Fidock

Trends Parasitol· September 2016

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A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms.
Didier Ménard, Nimol Khim, Johann Beghain, Ayola A Adegnika, Mohammad Shafiul-Alam, Judith Straimer

N Engl J Med· June 2016

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Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies.
M Isabel Veiga, Satish K Dhingra, Philipp P Henrich, Judith Straimer, Nina Gnädig

Nat Commun· May 2016

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Balancing drug resistance and growth rates via compensatory mutations in the Plasmodium falciparum chloroquine resistance transporter.
Ines Petersen, Stanislaw J Gabryszewski, Geoffrey L Johnston, Satish K Dhingra, Andrea Ecker, Judith Straimer

Mol Microbiol· July 2015

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Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance.
Con Dogovski, Stanley C Xie, Gaetan Burgio, Jess Bridgford, Sachel Mok, Judith Straimer

PLoS Biol· April 2015

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Editing the Plasmodium vivax genome, using zinc-finger nucleases.
Roberto R Moraes Barros, Judith Straimer, Juliana M Sa, Rebecca E Salzman, Viviana A Melendez-Muniz

J Infect Dis· January 2015

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Drug resistance. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates.
Judith Straimer, Nina F Gnädig, Benoit Witkowski, Chanaki Amaratunga, Valentine Duru

Science· January 2015

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Genome-wide screen identifies new candidate genes associated with artemisinin susceptibility in Plasmodium falciparum in Kenya.
Steffen Borrmann, Judith Straimer, Leah Mwai, Abdirahman Abdi, Anja Rippert

Sci Rep· November 2013

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Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases.
Judith Straimer, Marcus C S Lee, Andrew H Lee, Bryan Zeitler, April E Williams

Nat Methods· October 2012

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In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa.
Philip Sasi, Abdi Abdulrahaman, Leah Mwai, Steven Muriithi, Judith Straimer

J Infect Dis· June 2009

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