Publications by authors named "Julian Fuchs"

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Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control.
Julien Chilloux, Francois Brial, Amandine Everard, David Smyth, Petros Andrikopoulos, Julian E Fuchs

Nat Metab· December 2025

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Discovery of Macrocyclic Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors that Demonstrate Potent Cellular Efficacy and In Vivo Activity in a Mouse Solid Tumor Xenograft Model.
James C Tarr, Kyuok Jeon, Nagarathanam Veerasamy, Martin Aichinger, James M Salovich, Julian Emanuel Fuchs

J Med Chem· September 2025

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Discovery of BI-2493, a Pan-KRAS Inhibitor Showing Efficacy.
Joachim Bröker, Alex G Waterson, Timothy R Hodges, Jason R Abbott, Allison Arnold, Julian E Fuchs

J Med Chem· August 2025

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Drugit: crowd-sourcing molecular design of non-peptidic VHL binders.
Thomas Scott, Christian Alan Paul Smethurst, Yvonne Westermaier, Moriz Mayer, Peter Greb, Julian E Fuchs

Nat Commun· April 2025

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Biogeochemical Traits of a High Latitude South Pacific Ocean Calcareous Nannoplankton Community During the Oligocene.
Rosie M Sheward, Jens O Herrle, Julian Fuchs, Samantha J Gibbs, Paul R Bown

Paleoceanogr Paleoclimatol· December 2024

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Probing Protein-Ligand Methyl-π Interaction Geometries through Chemical Shift Measurements of Selectively Labeled Methyl Groups.
Andreas Beier, Gerald Platzer, Theresa Höfurthner, Aleksandra L Ptaszek, Roman J Lichtenecker, Julian E Fuchs

J Med Chem· August 2024

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Ligandability assessment of the C-terminal Rel-homology domain of NFAT1.
Jark Böttcher, Julian E Fuchs, Moriz Mayer, Jan Kahmann, Krzysztof M Zak

Arch Pharm (Weinheim)· June 2024

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Ligand H NMR Chemical Shifts as Accurate Reporters for Protein-Ligand Binding Interfaces in Solution.
Gerald Platzer, Aleksandra L Ptaszek, Jark Böttcher, Julian E Fuchs, Leonhard Geist

Chemphyschem· January 2024

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Discovery of a Chemical Probe to Study Implications of BPTF Bromodomain Inhibition in Cellular and in vivo Experiments.
Paola Martinelli, Otmar Schaaf, Andreas Mantoulidis, Laetitia J Martin, Julian E Fuchs

ChemMedChem· March 2023

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A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo.
Christiane Kofink, Nicole Trainor, Barbara Mair, Simon Wöhrle, Melanie Wurm, Julian E Fuchs

Nat Commun· October 2022

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Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signaling.
Birgit Wilding, Dirk Scharn, Dietrich Böse, Anke Baum, Valeria Santoro, Julian E Fuchs

Nat Cancer· July 2022

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The impact of body mass index on prognosis in patients with colon carcinoma.
Julian Fuchs, Vera S Schellerer, Maximilian Brunner, Carol I Geppert, Robert Grützmann

Int J Colorectal Dis· May 2022

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A Step toward NRF2-DNA Interaction Inhibitors by Fragment-Based NMR Methods.
Sven Brüschweiler, Julian E Fuchs, Gerd Bader, Darryl B McConnell, Robert Konrat

ChemMedChem· December 2021

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Getting a Grip on the Undrugged: Targeting β-Catenin with Fragment-Based Methods.
Dirk Kessler, Moriz Mayer, Stephan K Zahn, Markus Zeeb, Simon Wöhrle, Julian E Fuchs

ChemMedChem· May 2021

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PI by NMR: Probing CH-π Interactions in Protein-Ligand Complexes by NMR Spectroscopy.
Gerald Platzer, Moriz Mayer, Andreas Beier, Sven Brüschweiler, Julian E Fuchs

Angew Chem Int Ed Engl· August 2020

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Correcting electrostatic artifacts due to net-charge changes in the calculation of ligand binding free energies.
Christoph Öhlknecht, Bettina Lier, Drazen Petrov, Julian Fuchs, Chris Oostenbrink

J Comput Chem· April 2020

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Pharmacological Targets of Kaempferol Within Inflammatory Pathways-A Hint Towards the Central Role of Tryptophan Metabolism.
Stefanie Hofer, Simon Geisler, Rebecca Lisandrelli, Hieu Nguyen Ngoc, Markus Ganzera, Dietmar Fuchs, Julian E Fuchs

Antioxidants (Basel)· February 2020

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Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors.
Harald Engelhardt, Dietrich Böse, Mark Petronczki, Dirk Scharn, Gerd Bader, Julian E Fuchs

J Med Chem· November 2019

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Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3.
Jark Böttcher, David Dilworth, Ulrich Reiser, Ralph A Neumüller, Michael Schleicher, Julian E Fuchs

Nat Chem Biol· August 2019

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Sulfated Ceria Catalyzed Synthesis of Imidazopyridines and Their Implementation as DNA Minor Groove Binders.
Surender Mohan, Shobith Rangappa, Nirvanappa C Anilkumar, Julian E Fuchs, Andreas Bender

Chem Biodivers· May 2019

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Targeted Synthesis of Complex Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-ones by Intramolecular Cyclization of Azomethine Ylides: Highly Potent MDM2-p53 Inhibitors.
Andreas Gollner, Harald Weinstabl, Julian E Fuchs, Dorothea Rudolph, Geraldine Garavel

ChemMedChem· January 2019

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Understanding Structure-Activity Relationships for Trypanosomal Cysteine Protease Inhibitors by Simulations and Free Energy Calculations.
Lucianna H Santos, Birgit J Waldner, Julian E Fuchs, Glaécia A N Pereira, Klaus R Liedl

J Chem Inf Model· January 2019

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Electrostatic recognition in substrate binding to serine proteases.
Birgit J Waldner, Johannes Kraml, Ursula Kahler, Alexander Spinn, Michael Schauperl, Julian E Fuchs

J Mol Recognit· October 2018

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Discovery of a small-molecule inhibitor of specific serine residue BAD phosphorylation.
Vijay Pandey, Baocheng Wang, Chakrabhavi Dhananjaya Mohan, Ainiah Rushdiana Raquib, Shobith Rangappa, Julian E Fuchs

Proc Natl Acad Sci U S A· October 2018

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Peptidic Macrocycles - Conformational Sampling and Thermodynamic Characterization.
Anna S Kamenik, Uta Lessel, Julian E Fuchs, Thomas Fox, Klaus R Liedl

J Chem Inf Model· May 2018

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