Publications by authors named "Julie Lade"

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Use of a Transgenic Human PNPLA3 Knock-in Mouse for Translational Safety Evaluations of siRNA Therapeutics.
Ben Brooks, Artem Shkumatov, Jackson Kalanzi, Kim Henderson Park, Julie M Lade

Nucleic Acid Ther· December 2025

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Liver-specific mitochondrial amidoxime-reducing component 1 (Mtarc1) knockdown protects the liver from diet-induced MASH in multiple mouse models.
Yuanjun Guo, Zhengyu Gao, Edward L LaGory, Lewis Wilson Kristin, Jamila Gupte, Julie Lade

Hepatol Commun· May 2024

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Hypoxia enhances interactions between Na/H exchanger isoform 1 and actin filaments ezrin in pulmonary vascular smooth muscle.
Julie M Lade, Manuella R Andrade, Clark Undem, Jasmine Walker, Haiyang Jiang

Front Physiol· February 2023

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Design and Measurement of Drug Tissue Concentration Asymmetry and Tissue Exposure-Effect (Tissue PK-PD) Evaluation.
Richard Zang, Aline Barth, Harvey Wong, Jan Marik, Jie Shen, Julie Lade

J Med Chem· July 2022

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Prolonged cultured human hepatocytes as an in vitro experimental system for the evaluation of potency and duration of activity of RNA therapeutics: Demonstration of prolonged duration of gene silencing effects of a GalNAc-conjugated human hypoxanthine phosphoribosyl transferase (HPRT1) siRNA.
Qian Yang, Sara C Humphreys, Julie M Lade, Albert P Li

Biochem Pharmacol· July 2021

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Metabolism of Long-Acting Rilpivirine After Intramuscular Injection: HIV Prevention Trials Network Study 076 (HPTN 076).
Herana Kamal Seneviratne, Joseph Tillotson, Julie M Lade, Linda-Gail Bekker, Sue Li

AIDS Res Hum Retroviruses· March 2021

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Introducing an In Vitro Liver Stability Assay Capable of Predicting the In Vivo Pharmacodynamic Efficacy of siRNAs for IVIVC.
Babak Basiri, Fang Xie, Bin Wu, Sara C Humphreys, Julie M Lade

Mol Ther Nucleic Acids· September 2020

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Emerging siRNA Design Principles and Consequences for Biotransformation and Disposition in Drug Development.
Sara C Humphreys, Mai B Thayer, Jabbar Campbell, Wen Li Kelly Chen, Dan Adams, Julie M Lade

J Med Chem· June 2020

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POE Immunoassay: Plate-based oligonucleotide electro-chemiluminescent immunoassay for the quantification of nucleic acids in biological matrices.
Mai B Thayer, Sara C Humphreys, Kyu S Chung, Julie M Lade, Kevin D Cook

Sci Rep· June 2020

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Plasma and Liver Protein Binding of -Acetylgalactosamine-Conjugated Small Interfering RNA.
Sara C Humphreys, Mai B Thayer, Julie M Lade, Bin Wu, Kelvin Sham

Drug Metab Dispos· October 2019

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Fraction Unbound for Liver Microsome and Hepatocyte Incubations for All Major Species Can Be Approximated Using a Single-Species Surrogate.
John T Barr, Julie M Lade, Thuy B Tran, Upendra P Dahal

Drug Metab Dispos· April 2019

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Application of Locked Nucleic Acid Oligonucleotides for siRNA Preclinical Bioanalytics.
Mai B Thayer, Julie M Lade, David Doherty, Fang Xie, Babak Basiri

Sci Rep· March 2019

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Rho kinase and Na /H exchanger mediate endothelin-1-induced pulmonary arterial smooth muscle cell proliferation and migration.
John C Huetsch, Jasmine Walker, Clark Undem, Julie Lade, Xin Yun

Physiol Rep· May 2018

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Probing Ligand Structure-Activity Relationships in Pregnane X Receptor (PXR): Efavirenz and 8-Hydroxyefavirenz Exhibit Divergence in Activation.
Bhargavi Narayanan, Julie M Lade, Carley J S Heck, Kevin D Dietz, Herschel Wade

ChemMedChem· April 2018

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Role of Rho kinase and Na+/H+ exchange in hypoxia-induced pulmonary arterial smooth muscle cell proliferation and migration.
Jasmine Walker, Clark Undem, Xin Yun, Julie Lade, Haiyang Jiang

Physiol Rep· March 2016

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Discovery of Genetic Variants of the Kinases That Activate Tenofovir in a Compartment-specific Manner.
Julie M Lade, Elaine E To, Craig W Hendrix, Namandjé N Bumpus

EBioMedicine· September 2015

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The aquaporin 1 C-terminal tail is required for migration and growth of pulmonary arterial myocytes.
Ning Lai, Julie Lade, Kyle Leggett, Xin Yun, Syeda Baksh

Am J Respir Cell Mol Biol· June 2014

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Human biotransformation of the nonnucleoside reverse transcriptase inhibitor rilpivirine and a cross-species metabolism comparison.
Julie M Lade, Lindsay B Avery, Namandjé N Bumpus

Antimicrob Agents Chemother· October 2013

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