Publications by authors named "Julien Ghislain"

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The role of the beta cell in type 2 diabetes: new findings from the last 5 years.
Belinda Yau, Julien Ghislain, Melkam A Kebede, Jing Hughes, Vincent Poitout

Diabetologia· October 2025

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Free fatty acid receptor 4 agonists stimulate insulin secretion via different mechanisms in mouse versus human islets.
Laura Reininger, Muhammad Rehman, Amélia Bouabcha, Sarah Ferragne, Caroline Tremblay, Julien Ghislain

bioRxiv· August 2025

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Single-Cell RNA Sequencing Reveals a Role for Reactive Oxygen Species and Peroxiredoxins in Fatty Acid-Induced Rat β-Cell Proliferation.
Alexis Vivoli, Julien Ghislain, Ali Filali-Mouhim, Zuraya Elisa Angeles, Anne-Laure Castell

Diabetes· January 2023

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β Cell mass expansion during puberty involves serotonin signaling and determines glucose homeostasis in adulthood.
Anne-Laure Castell, Clara Goubault, Mélanie Ethier, Grace Fergusson, Caroline Tremblay, Julien Ghislain

JCI Insight· November 2022

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Very-Long-Chain Unsaturated Sphingolipids Mediate Oleate-Induced Rat β-Cell Proliferation.
Anne-Laure Castell, Alexis Vivoli, Trevor S Tippetts, Isabelle Robillard Frayne, Zuraya Elisa Angeles, Julien Ghislain

Diabetes· June 2022

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Pronounced proliferation of non-beta cells in response to beta-cell mitogens in isolated human islets of Langerhans.
Hasna Maachi, Julien Ghislain, Caroline Tremblay, Vincent Poitout

Sci Rep· May 2021

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Free fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice.
Marine L Croze, Marcus F Flisher, Arthur Guillaume, Caroline Tremblay, Glyn M Noguchi, Julien Ghislain

Mol Metab· March 2021

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Targeting lipid GPCRs to treat type 2 diabetes mellitus - progress and challenges.
Julien Ghislain, Vincent Poitout

Nat Rev Endocrinol· March 2021

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Combined Deletion of Free Fatty-Acid Receptors 1 and 4 Minimally Impacts Glucose Homeostasis in Mice.
Marine L Croze, Arthur Guillaume, Mélanie Ethier, Grace Fergusson, Caroline Tremblay, Julien Ghislain

Endocrinology· March 2021

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HB-EGF Signaling Is Required for Glucose-Induced Pancreatic β-Cell Proliferation in Rats.
Hasna Maachi, Grace Fergusson, Melanie Ethier, Gabriel N Brill, Liora S Katz, Julien Ghislain

Diabetes· March 2020

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The autonomic nervous system regulates pancreatic β-cell proliferation in adult male rats.
Valentine S Moullé, Caroline Tremblay, Anne-Laure Castell, Kevin Vivot, Mélanie Ethier, Julien Ghislain

Am J Physiol Endocrinol Metab· August 2019

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Deletion of Protein Kinase D1 in Pancreatic β-Cells Impairs Insulin Secretion in High-Fat Diet-Fed Mice.
Valérie Bergeron, Julien Ghislain, Kevin Vivot, Natalia Tamarina, Louis H Philipson

Diabetes· January 2018

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Nutrient regulation of pancreatic β-cell proliferation.
Valentine S Moullé, Julien Ghislain, Vincent Poitout

Biochimie· December 2017

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The Role and Future of FFA1 as a Therapeutic Target.
Julien Ghislain, Vincent Poitout

Handb Exp Pharmacol· September 2017

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Glucose and fatty acids synergistically and reversibly promote beta cell proliferation in rats.
Valentine S Moullé, Kevin Vivot, Caroline Tremblay, Bader Zarrouki, Julien Ghislain

Diabetologia· May 2017

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The P21-activated kinase PAK4 is implicated in fatty-acid potentiation of insulin secretion downstream of free fatty acid receptor 1.
Valérie Bergeron, Julien Ghislain, Vincent Poitout

Islets· November 2016

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The regulator of G-protein signaling RGS16 promotes insulin secretion and β-cell proliferation in rodent and human islets.
Kevin Vivot, Valentine S Moullé, Bader Zarrouki, Caroline Tremblay, Arturo D Mancini, Julien Ghislain

Mol Metab· October 2016

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Urea impairs β cell glycolysis and insulin secretion in chronic kidney disease.
Laetitia Koppe, Elsa Nyam, Kevin Vivot, Jocelyn E Manning Fox, Xiao-Qing Dai, Julien Ghislain

J Clin Invest· September 2016

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Dual-Reporter β-Cell-Specific Male Transgenic Rats for the Analysis of β-Cell Functional Mass and Enrichment by Flow Cytometry.
Julien Ghislain, Ghislaine Fontés, Caroline Tremblay, Melkam A Kebede, Vincent Poitout

Endocrinology· March 2016

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The ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Is Associated With Progressive Insulin Resistance and Decreased Functional β-Cell Mass in Mice.
Ghislaine Fontés, Julien Ghislain, Isma Benterki, Bader Zarrouki, Dominique Trudel

Diabetes· December 2015

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β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1.
Arturo D Mancini, Gyslaine Bertrand, Kevin Vivot, Éric Carpentier, Caroline Tremblay, Julien Ghislain

J Biol Chem· August 2015

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Pancreatic and duodenal homeobox-1 nuclear localization is regulated by glucose in dispersed rat islets but not in insulin-secreting cell lines.
Meriem Semache, Julien Ghislain, Bader Zarrouki, Caroline Tremblay, Vincent Poitout

Islets· July 2015

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Spontaneous glycine-induced calcium transients in spinal cord progenitors promote neurogenesis.
Edna Brustein, Sébastien Côté, Julien Ghislain, Pierre Drapeau

Dev Neurobiol· February 2013

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FGF-receptor signalling controls neural cell diversity in the zebrafish hindbrain by regulating olig2 and sox9.
Virginie Esain, John H Postlethwait, Patrick Charnay, Julien Ghislain

Development· January 2010

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Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors.
Michel A Wassef, Diane Chomette, Marie Pouilhe, Aline Stedman, Emmanuelle Havis, Julien Ghislain

Development· October 2008

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