Publications by authors named "Meriem Semache"

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Virtual library docking for cannabinoid-1 receptor agonists with reduced side effects.
Tia A Tummino, Christos Iliopoulos-Tsoutsouvas, Joao M Braz, Evan S O'Brien, Reed M Stein, Meriem Semache

Nat Commun· March 2025

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Large library docking for cannabinoid-1 receptor agonists with reduced side effects.
Tia A Tummino, Christos Iliopoulos-Tsoutsouvas, Joao M Braz, Evan S O'Brien, Reed M Stein, Meriem Semache

bioRxiv· February 2024

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Chronic UCN2 treatment desensitizes CRHR2 and improves insulin sensitivity.
Stephen E Flaherty, Olivier Bezy, Wei Zheng, Dong Yan, Xiangping Li, Meriem Semache

Nat Commun· July 2023

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Ackr3-Venus knock-in mouse lights up brain vasculature.
Aliza T Ehrlich, Meriem Semache, Pierre Couvineau, Stefan Wojcik, Hiroyuki Kobayashi

Mol Brain· September 2021

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Mechanistic insights into dopaminergic and serotonergic neurotransmission - concerted interactions with helices 5 and 6 drive the functional outcome.
Tomasz Maciej Stepniewski, Arturo Mancini, Richard Ågren, Mariona Torrens-Fontanals, Meriem Semache

Chem Sci· August 2021

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The PAR2 inhibitor I-287 selectively targets Gα and Gα signaling and has anti-inflammatory effects.
Charlotte Avet, Claudio Sturino, Sébastien Grastilleur, Christian Le Gouill, Meriem Semache

Commun Biol· November 2020

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Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons.
Aliza T Ehrlich, Meriem Semache, Florence Gross, Dillon F Da Fonte, Leonie Runtz

iScience· April 2019

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Mapping GPR88-Venus illuminates a novel role for GPR88 in sensory processing.
Aliza T Ehrlich, Meriem Semache, Julie Bailly, Stefan Wojcik, Tanzil M Arefin

Brain Struct Funct· April 2018

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Pancreatic and duodenal homeobox-1 nuclear localization is regulated by glucose in dispersed rat islets but not in insulin-secreting cell lines.
Meriem Semache, Julien Ghislain, Bader Zarrouki, Caroline Tremblay, Vincent Poitout

Islets· July 2015

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Per-Arnt-Sim kinase regulates pancreatic duodenal homeobox-1 protein stability via phosphorylation of glycogen synthase kinase 3β in pancreatic β-cells.
Meriem Semache, Bader Zarrouki, Ghislaine Fontés, Sarah Fogarty, Chintan Kikani

J Biol Chem· August 2013

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Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via Toll-Like Receptor-4 and NF-κB signalling.
Julie Amyot, Meriem Semache, Mourad Ferdaoussi, Ghislaine Fontés, Vincent Poitout

PLoS One· September 2012

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Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion.
Francesca Semplici, Martine Vaxillaire, Sarah Fogarty, Meriem Semache, Amélie Bonnefond

J Biol Chem· December 2011

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Glucolipotoxicity of the pancreatic beta cell.
Vincent Poitout, Julie Amyot, Meriem Semache, Bader Zarrouki, Derek Hagman

Biochim Biophys Acta· March 2010

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Lack of preservation of insulin gene expression by a glucagon-like peptide 1 agonist or a dipeptidyl peptidase 4 inhibitor in an in vivo model of glucolipotoxicity.
Ghislaine Fontés, Derek K Hagman, Martin G Latour, Meriem Semache, Vincent Poitout

Diabetes Res Clin Pract· March 2010

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Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.
Ghislaine Fontés, Meriem Semache, Derek K Hagman, Caroline Tremblay, Ramila Shah

Diabetes· September 2009

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Lipolysis and the integrated physiology of lipid energy metabolism.
Shupei Wang, Krishnakant G Soni, Meriem Semache, Stéphanie Casavant, Mélanie Fortier

Mol Genet Metab· November 2008

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The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding.
Melkam Kebede, Thierry Alquier, Martin G Latour, Meriem Semache, Caroline Tremblay

Diabetes· September 2008

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Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets.
Derek K Hagman, Martin G Latour, Swarup K Chakrabarti, Ghislaine Fontes, Julie Amyot, Meriem Semache

Diabetes· February 2008

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Carboxylesterase 3 (EC 3.1.1.1) is a major adipocyte lipase.
Krishnakant G Soni, Richard Lehner, Pavel Metalnikov, Paul O'Donnell, Meriem Semache

J Biol Chem· September 2004

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Hormone-sensitive lipase-independent adipocyte lipolysis during beta-adrenergic stimulation, fasting, and dietary fat loading.
Mélanie Fortier, Shu Pei Wang, Pascale Mauriège, Meriem Semache, Léandra Mfuma

Am J Physiol Endocrinol Metab· August 2004

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