Publications by authors named "Julien Muffat"

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mTORC1 and mTORC2 synergy in human neural development, disease, and regeneration.
Navroop K Dhaliwal, Julien Muffat, Yun Li

Neural Regen Res· April 2026

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Long-read proteogenomic atlas of human neuronal differentiation reveals isoform diversity informing neurodevelopmental risk mechanisms.
Nuo Xu, Katherine M Rynard, Elizabeth Radley, Ai Tian, Maahil Arshad, Julien Muffat

bioRxiv· December 2025

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Expanding the neuroimmune research toolkit with in vivo brain organoid technologies.
Ai Tian, Afrin Bhattacharya, Julien Muffat, Yun Li

Dis Model Mech· April 2025

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The use of a multi-metric readout screen to identify EHMT2/G9a-inhibition as a modulator of cancer-associated fibroblast activation state.
Nila C Wu, Rene Quevedo, Michelle Nurse, Kebria Hezaveh, Haijiao Liu, Julien Muffat

Biomaterials· March 2025

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Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids.
Navroop K Dhaliwal, Octavia Yifang Weng, Xiaoxue Dong, Afrin Bhattacharya, Mai Ahmed, Julien Muffat

Cell Rep· May 2024

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Universal, label-free, single-molecule visualization of DNA origami nanodevices across biological samples using origamiFISH.
Wendy Xueyi Wang, Travis R Douglas, Haiwang Zhang, Afrin Bhattacharya, Meghan Rothenbroker, Julien Muffat

Nat Nanotechnol· January 2024

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Understanding neural development and diseases using CRISPR screens in human pluripotent stem cell-derived cultures.
Mai Ahmed, Julien Muffat, Yun Li

Front Cell Dev Biol· April 2023

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Modeling Developmental Brain Diseases Using Human Pluripotent Stem Cells-Derived Brain Organoids - Progress and Perspective.
Afrin Bhattacharya, Wendy W Y Choi, Julien Muffat, Yun Li

J Mol Biol· February 2022

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Modeling PTEN overexpression-induced microcephaly in human brain organoids.
Navroop Dhaliwal, Wendy W Y Choi, Julien Muffat, Yun Li

Mol Brain· August 2021

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Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases.
Martin Trapecar, Emile Wogram, Devon Svoboda, Catherine Communal, Attya Omer, Julien Muffat

Sci Adv· January 2021

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Emerging technologies to study glial cells.
Hélène Hirbec, Nicole Déglon, Lynette C Foo, Inbal Goshen, Jaime Grutzendler, Julien Muffat

Glia· September 2020

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Studying Human Neurodevelopment and Diseases Using 3D Brain Organoids.
Ai Tian, Julien Muffat, Yun Li

J Neurosci· February 2020

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Genome-wide CRISPR screen for Zika virus resistance in human neural cells.
Yun Li, Julien Muffat, Attya Omer Javed, Heather R Keys, Tenzin Lungjangwa

Proc Natl Acad Sci U S A· May 2019

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Microcephaly Modeling of Kinetochore Mutation Reveals a Brain-Specific Phenotype.
Attya Omer Javed, Yun Li, Julien Muffat, Kuan-Chung Su, Malkiel A Cohen

Cell Rep· October 2018

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Human induced pluripotent stem cell-derived glial cells and neural progenitors display divergent responses to Zika and dengue infections.
Julien Muffat, Yun Li, Attya Omer, Ann Durbin, Irene Bosch

Proc Natl Acad Sci U S A· July 2018

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Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene.
X Shawn Liu, Hao Wu, Marine Krzisch, Xuebing Wu, John Graef, Julien Muffat

Cell· February 2018

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Induction of Expansion and Folding in Human Cerebral Organoids.
Yun Li, Julien Muffat, Attya Omer, Irene Bosch, Madeline A Lancaster

Cell Stem Cell· March 2017

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CNS disease models with human pluripotent stem cells in the CRISPR age.
Julien Muffat, Yun Li, Rudolf Jaenisch

Curr Opin Cell Biol· December 2016

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Efficient derivation of microglia-like cells from human pluripotent stem cells.
Julien Muffat, Yun Li, Bingbing Yuan, Maisam Mitalipova, Attya Omer

Nat Med· November 2016

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A three-dimensional human neural cell culture model of Alzheimer's disease.
Se Hoon Choi, Young Hye Kim, Matthias Hebisch, Christopher Sliwinski, Seungkyu Lee, Julien Muffat

Nature· November 2014

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ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state.
Yakov Chudnovsky, Dohoon Kim, Siyuan Zheng, Warren A Whyte, Mukesh Bansal, Julien Muffat

Cell Rep· January 2014

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Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.
Chee Yeun Chung, Vikram Khurana, Pavan K Auluck, Daniel F Tardiff, Joseph R Mazzulli, Julien Muffat

Science· November 2013

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Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons.
Yun Li, Haoyi Wang, Julien Muffat, Albert W Cheng, David A Orlando

Cell Stem Cell· October 2013

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Surface-engineered substrates for improved human pluripotent stem cell culture under fully defined conditions.
Krishanu Saha, Ying Mei, Colin M Reisterer, Neena Kenton Pyzocha, Jing Yang, Julien Muffat

Proc Natl Acad Sci U S A· November 2011

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Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations.
Christopher J Lengner, Alexander A Gimelbrant, Jennifer A Erwin, Albert Wu Cheng, Matthew G Guenther, Julien Muffat

Cell· May 2010

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