Publications by authors named "Junya Isobe"

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Combination therapy with levofloxacin and the probiotic Clostridium butyricum MIYAIRI 588 enhances immune checkpoint inhibitor efficacy.
Kohei Tajima, Masahiro Hosonuma, Eiji Funayama, Junya Isobe, Yuta Baba

Int J Cancer· September 2025

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Inosine shapes PD-1 blockade responses and synergizes with dual PD-1/CTLA-4 immunotherapy to enhance antitumor immunity.
Yoichiro Narikawa, Atsuo Kuramasu, Masahiro Hosonuma, Masakazu Murayama, Eiji Funayama, Junya Isobe

Cancer Immunol Immunother· August 2025

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and are associated with aging of the gut microbiota and affect the efficacy of immune checkpoint inhibitors.
Yuya Hirasawa, Junya Isobe, Masahiro Hosonuma, Toshiaki Tsurui, Yuta Baba

Front Immunol· June 2025

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Ki-67 expression in anti-programmed cell death protein-1 antibody-bound CD8 T cells as a predictor of clinical benefit.
Toshiaki Tsurui, Masahiro Hosonuma, Aya Sasaki, Yuuki Maruyama, Yasunobu Amari, Junya Isobe

Discov Oncol· March 2025

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Association between the gene polymorphism-determined earwax properties and external auditory canal microbiota in healthy adults.
Yasunobu Amari, Masahiro Hosonuma, Takuya Mizukami, Junya Isobe, Yuki Azetsu

Microbiol Spectr· February 2025

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Oral administration of Bifidobacterium longum and Bifidobacterium infantis ameliorates cefcapene pivoxil-induced attenuation of anti-programmed cell death protein-1 antibody action in mice.
Eiji Funayama, Masahiro Hosonuma, Kohei Tajima, Junya Isobe, Yuta Baba

Biomed Pharmacother· January 2025

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MHC class I polypeptide-related sequence B shedding modulates pancreatic tumor immunity via the activation of NKG2D T cells.
Hitoshi Toyoda, Atsuo Kuramasu, Masahiro Hosonuma, Masakazu Murayama, Yoichiro Narikawa, Junya Isobe

Sci Rep· October 2024

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Isobutyric acid enhances the anti-tumour effect of anti-PD-1 antibody.
Masakazu Murayama, Masahiro Hosonuma, Atsuo Kuramasu, Sei Kobayashi, Akiko Sasaki, Junya Isobe

Sci Rep· May 2024

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Nivolumab receptor occupancy on effector regulatory T cells predicts clinical benefit.
Masahiro Hosonuma, Yuya Hirasawa, Atsuo Kuramasu, Masakazu Murayama, Yoichiro Narikawa, Junya Isobe

Cancer Sci· March 2024

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Butyricimonas is a key gut microbiome component for predicting postoperative recurrence of esophageal cancer.
Koji Otsuka, Junya Isobe, Yoshiyuki Asai, Tomohisa Nakano, Kouya Hattori

Cancer Immunol Immunother· January 2024

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and predict immune-related adverse events and efficacy of immune checkpoint inhibitor.
Kazuyuki Hamada, Junya Isobe, Kouya Hattori, Masahiro Hosonuma, Yuta Baba

Front Immunol· May 2023

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Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells.
Daisuke Takahashi, Naomi Hoshina, Yuma Kabumoto, Yuichi Maeda, Akari Suzuki, Junya Isobe

EBioMedicine· August 2020

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Commensal-bacteria-derived butyrate promotes the T-cell-independent IgA response in the colon.
Junya Isobe, Shintarou Maeda, Yuuki Obata, Keito Iizuka, Yutaka Nakamura

Int Immunol· April 2020

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