Publications by authors named "Justin Murray"

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Use of a Transgenic Human PNPLA3 Knock-in Mouse for Translational Safety Evaluations of siRNA Therapeutics.
Ben Brooks, Artem Shkumatov, Jackson Kalanzi, Kim Henderson Park, Julie M Lade, Justin K Murray

Nucleic Acid Ther· December 2025

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Pathogenesis of Hazara orthonairovirus infection in type I interferon receptor-deficient mice and resolution of disease following 4'-fluorouridine therapy.
Justin S Murray, Jonna B Westover, Dionna Scharton, Arnaud J Van Wettere, Alexander A Kolykhalov

J Virol· December 2025

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Surface Plasmon Resonance Based Binding Characterization for Screening RNA-Loaded Lipid Nanoparticles (LNPs): Exploring Species Cross-Reactivity in LNP-Apolipoprotein E Interactions.
Benjamin Lew, Sandeep Chhabra, Jacob A Lewis, Angela C Wagoner, Angel Hsu, Justin K Murray

Mol Pharm· August 2025

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A replicating RNA vaccine confers protection against Crimean-Congo hemorrhagic fever in cynomolgus macaques.
David W Hawman, Shanna Leventhal, Kimberly Meade-White, William Graham, Karen Gaffney, Justin Murray

EBioMedicine· May 2025

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Antibodies targeting the Crimean-Congo Hemorrhagic Fever Virus nucleoprotein protect via TRIM21.
Shanna S Leventhal, Thomas Bisom, Dean Clift, Deepashri Rao, Kimberly Meade-White, Justin Murray

Nat Commun· October 2024

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Liver-specific mitochondrial amidoxime-reducing component 1 (Mtarc1) knockdown protects the liver from diet-induced MASH in multiple mouse models.
Yuanjun Guo, Zhengyu Gao, Edward L LaGory, Lewis Wilson Kristin, Jamila Gupte, Justin K Murray

Hepatol Commun· May 2024

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A replicating RNA vaccine confers protection in a rhesus macaque model of Crimean-Congo hemorrhagic fever.
David W Hawman, Shanna S Leventhal, Kimberly Meade-White, Amit Khandhar, Justin Murray

NPJ Vaccines· May 2024

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Restoration of virulence in the attenuated Candid#1 vaccine virus requires reversion at both positions 168 and 427 in the envelope glycoprotein GPC.
Jack H Nunberg, Jonna B Westover, Joanne York, Kie Hoon Jung, Kevin W Bailey, Justin S Murray

J Virol· April 2024

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Purification of N-acetylgalactosamine-modified-oligonucleotides using orthogonal anion-exchange and mixed-mode chromatography approaches.
Artaches A Kazarian, Wesley Barnhart, Jason Long, Kelvin Sham, Bin Wu, Justin K Murray

J Chromatogr A· January 2022

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Identification and Optimization of a Minor Allele-Specific siRNA to Prevent PNPLA3 I148M-Driven Nonalcoholic Fatty Liver Disease.
Justin K Murray, Jason Long, Lei Liu, Shivani Singh, Danielle Pruitt

Nucleic Acid Ther· October 2021

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Purification of guanine-quadruplex using monolithic stationary phase under ion-exchange conditions.
Artaches A Kazarian, Wesley Barnhart, Iain D G Campuzano, Jeremy Cabrera, Theodore Fitch, Justin K Murray

J Chromatogr A· December 2020

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Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species.
Robert S Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Justin Murray

Drug Metab Dispos· October 2019

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Engineering Na1.7 Inhibitory JzTx-V Peptides with a Potency and Basicity Profile Suitable for Antibody Conjugation To Enhance Pharmacokinetics.
Justin K Murray, Bin Wu, Christopher M Tegley, Thomas E Nixey, James R Falsey

ACS Chem Biol· April 2019

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Discovery of Tarantula Venom-Derived Na1.7-Inhibitory JzTx-V Peptide 5-Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis.
Bin Wu, Justin K Murray, Kristin L Andrews, Kelvin Sham, Jason Long

J Med Chem· November 2018

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Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V.
Bryan D Moyer, Justin K Murray, Joseph Ligutti, Kristin Andrews, Philippe Favreau

PLoS One· August 2018

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Engineering Antibody Reactivity for Efficient Derivatization to Generate Na1.7 Inhibitory GpTx-1 Peptide-Antibody Conjugates.
Kaustav Biswas, Thomas E Nixey, Justin K Murray, James R Falsey, Li Yin

ACS Chem Biol· September 2017

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Single Residue Substitutions That Confer Voltage-Gated Sodium Ion Channel Subtype Selectivity in the NaV1.7 Inhibitory Peptide GpTx-1.
Justin K Murray, Jason Long, Anruo Zou, Joseph Ligutti, Kristin L Andrews

J Med Chem· March 2016

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Sustained inhibition of the NaV1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1.
Justin K Murray, Kaustav Biswas, J Ryan Holder, Anruo Zou, Joseph Ligutti

Bioorg Med Chem Lett· November 2015

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Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3.
Justin K Murray, Yi-Xin Qian, Benxian Liu, Robin Elliott, Jennifer Aral

J Med Chem· September 2015

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Engineering potent and selective analogues of GpTx-1, a tarantula venom peptide antagonist of the Na(V)1.7 sodium channel.
Justin K Murray, Joseph Ligutti, Dong Liu, Anruo Zou, Leszek Poppe

J Med Chem· March 2015

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PADLOC: a powerful tool to assign disulfide bond connectivities in peptides and proteins by NMR spectroscopy.
Leszek Poppe, John O Hui, Joseph Ligutti, Justin K Murray, Paul D Schnier

Anal Chem· January 2012

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Solid-phase peptide synthesis using microwave irradiation.
Justin K Murray, Jennifer Aral, Les P Miranda

Methods Mol Biol· May 2011

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Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1α prolyl hydroxylases-1, -2, and -3 with altered selectivity.
Justin K Murray, Chenera Balan, Alan M Allgeier, Annie Kasparian, Vellarkad Viswanadhan

J Comb Chem· September 2010

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PRX-08066, a novel 5-hydroxytryptamine receptor 2B antagonist, reduces monocrotaline-induced pulmonary arterial hypertension and right ventricular hypertrophy in rats.
Stacy L Porvasnik, Sean Germain, Jennifer Embury, Kimberley S Gannon, Vincent Jacques, Justin Murray

J Pharmacol Exp Ther· August 2010

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A combination of ultrahigh throughput PathHunter and cytokine secretion assays to identify glucocorticoid receptor agonists.
Amita Patel, Justin Murray, Sheila McElwee-Whitmer, Chang Bai, Priya Kunapuli

Anal Biochem· February 2009

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