Publications by authors named "KJ Vos"

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RuvBL1/2 reduce toxic dipeptide repeat protein burden in multiple models of C9orf72-ALS/FTD.
Christopher P Webster, Bradley Hall, Olivia M Crossley, Dana Dauletalina, Marianne King, Kurt J De Vos

Life Sci Alliance· February 2025

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A cell-penetrant peptide blocking -repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins.
Lydia M Castelli, Ya-Hui Lin, Alvaro Sanchez-Martinez, Aytaç Gül, Kamallia Mohd Imran, Kurt J De Vos

Sci Transl Med· March 2023

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Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation.
Claudia S Bauer, Christopher P Webster, Allan C Shaw, Jannigje R Kok, Lydia M Castelli, Kurt J De Vos

Front Cell Neurosci· December 2022

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-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons.
Paolo M Marchi, Lara Marrone, Laurent Brasseur, Audrey Coens, Christopher P Webster, Kurt J De Vos

Life Sci Alliance· September 2022

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An interaction between synapsin and C9orf72 regulates excitatory synapses and is impaired in ALS/FTD.
Claudia S Bauer, Rebecca N Cohen, Francesca Sironi, Matthew R Livesey, Thomas H Gillingwater, Kurt J De Vos

Acta Neuropathol· September 2022

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Objective assessment of chronic pain in donkeys using the donkey chronic pain scale (DCPS): A scale-construction study.
Johannes P A M van Loon, Janny C de Grauw, Faith Burden, Kayleigh J Vos, Lyanne H Bardelmeijer

Vet J· January 2021

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The role of mitochondria in amyotrophic lateral sclerosis.
Emma F Smith, Pamela J Shaw, Kurt J De Vos

Neurosci Lett· September 2019

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Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis.
Scott P Allen, Benjamin Hall, Lydia M Castelli, Laura Francis, Ryan Woof, Kurt J De Vos

Brain· March 2019

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C9orf72 plays a central role in Rab GTPase-dependent regulation of autophagy.
Christopher P Webster, Emma F Smith, Andrew J Grierson, Kurt J De Vos

Small GTPases· September 2018

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Amyotrophic lateral sclerosis-associated mutant SOD1 inhibits anterograde axonal transport of mitochondria by reducing Miro1 levels.
Annekathrin Moller, Claudia S Bauer, Rebecca N Cohen, Christopher P Webster, Kurt J De Vos

Hum Mol Genet· December 2017

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Axonal Transport Defects in a Mitofusin 2 Loss of Function Model of Charcot-Marie-Tooth Disease in Zebrafish.
Anna L Chapman, Ellen J Bennett, Tennore M Ramesh, Kurt J De Vos, Andrew J Grierson

PLoS One· October 2017

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Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research?
Kurt J De Vos, Majid Hafezparast

Neurobiol Dis· September 2017

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C9orf72 expansion disrupts ATM-mediated chromosomal break repair.
Callum Walker, Saul Herranz-Martin, Evangelia Karyka, Chunyan Liao, Katherine Lewis, Kurt J De Vos

Nat Neurosci· September 2017

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SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits.
Guillaume M Hautbergue, Lydia M Castelli, Laura Ferraiuolo, Alvaro Sanchez-Martinez, Johnathan Cooper-Knock, Kurt J De Vos

Nat Commun· July 2017

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Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?
Christopher P Webster, Emma F Smith, Pamela J Shaw, Kurt J De Vos

Front Mol Neurosci· May 2017

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C9ORF72 hexanucleotide repeat exerts toxicity in a stable, inducible motor neuronal cell model, which is rescued by partial depletion of Pten.
Matthew J Stopford, Adrian Higginbottom, Guillaume M Hautbergue, Johnathan Cooper-Knock, Padraig J Mulcahy, Kurt J De Vos

Hum Mol Genet· March 2017

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ALS/FTD-associated FUS activates GSK-3β to disrupt the VAPB-PTPIP51 interaction and ER-mitochondria associations.
Radu Stoica, Sébastien Paillusson, Patricia Gomez-Suaga, Jacqueline C Mitchell, Dawn Hw Lau, Kurt J De Vos

EMBO Rep· September 2016

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The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy.
Christopher P Webster, Emma F Smith, Claudia S Bauer, Annekathrin Moller, Guillaume M Hautbergue, Kurt J De Vos

EMBO J· August 2016

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Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons.
Teresa Rodríguez-Martín, Amy M Pooler, Dawn H W Lau, Gábor M Mórotz, Kurt J De Vos

Neurobiol Dis· January 2016

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Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations.
Vinay K Godena, Nicholas Brookes-Hocking, Annekathrin Moller, Gary Shaw, Matthew Oswald, Kurt J De Vos

Nat Commun· October 2014

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ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43.
Radu Stoica, Kurt J De Vos, Sébastien Paillusson, Sarah Mueller, Rosa M Sancho

Nat Commun· June 2014

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Lemur tyrosine kinase-2 signalling regulates kinesin-1 light chain-2 phosphorylation and binding of Smad2 cargo.
C Manser, F Guillot, A Vagnoni, J Davies, K-F Lau, K J De Vos

Oncogene· May 2012

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Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria.
Gábor M Mórotz, Kurt J De Vos, Alessio Vagnoni, Steven Ackerley, Christopher E Shaw

Hum Mol Genet· May 2012

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VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis.
Kurt J De Vos, Gábor M Mórotz, Radu Stoica, Elizabeth L Tudor, Kwok-Fai Lau

Hum Mol Genet· March 2012

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Esomeprazole relieves upper gastrointestinal symptoms in high-risk and average-risk NSAID users in daily clinical practice: results from an open-label study.
Merel M Tielemans, Martijn G H van Oijen, Chris J J Mulder, Kees J Vos, Willem F Lems

Eur J Gastroenterol Hepatol· March 2012

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