Publications by authors named "Kai F Cheng"

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Novel small-molecule inhibitors of the protein kinase DYRK: Potential therapeutic candidates in cancer.
Prabhadevi Venkataramani, Elad Elkayam, Ankur Garg, Kai Fan Cheng, Ahmad Altiti

bioRxiv· November 2025

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Protease-Resistant Azapeptide GLP-1 Analogue Improves Metabolic Control in Diet-Induced Obesity.
Mingzhu He, Kai Fan Cheng, Sonya VanPatten, Marcelo D T Torres, Bayan Al Jabari

bioRxiv· November 2025

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Atom-level backbone engineering preserves peptide function while enhancing stability.
Mingzhu He, Kai Fan Cheng, Anh Vu, Marcelo D T Torres, Stavros Zanos

bioRxiv· November 2025

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Thiocarbazate building blocks enable the construction of azapeptides for rapid development of therapeutic candidates.
Ahmad Altiti, Mingzhu He, Sonya VanPatten, Kai Fan Cheng, Umair Ahmed

Nat Commun· November 2022

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Evidence supporting the use of peptides and peptidomimetics as potential SARS-CoV-2 (COVID-19) therapeutics.
Sonya VanPatten, Mingzhu He, Ahmad Altiti, Kai F Cheng, Mustafa H Ghanem

Future Med Chem· September 2020

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Endogenous retroviruses are associated with hippocampus-based memory impairment.
Roman Sankowski, Joshua J Strohl, Tomás S Huerta, Elham Nasiri, Andrea N Mazzarello, Kai Fan Cheng

Proc Natl Acad Sci U S A· December 2019

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Inhibition of HMGB1/RAGE-mediated endocytosis by HMGB1 antagonist box A, anti-HMGB1 antibodies, and cholinergic agonists suppresses inflammation.
Huan Yang, Hui Liu, Qiong Zeng, Gavin H Imperato, Meghan E Addorisio, Kai Fan Cheng

Mol Med· April 2019

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A structural investigation of FISLE-412, a peptidomimetic compound derived from saquinavir that targets lupus autoantibodies.
Mingzhu He, Kai Fan Cheng, Sonya VanPatten, Ona Bloom, Betty Diamond

Bioorg Med Chem Lett· October 2017

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β-Hydroxy-tetrahydroquinolines from Quinolines Using Chloroborane: Synthesis of the Peptidomimetic FISLE-412.
Ahmad S Altiti, Kai Fan Cheng, Mingzhu He, Yousef Al-Abed

Chemistry· August 2017

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Identification of Iguratimod as an Inhibitor of Macrophage Migration Inhibitory Factor (MIF) with Steroid-sparing Potential.
Joshua Bloom, Christine Metz, Saisha Nalawade, Julian Casabar, Kai Fan Cheng

J Biol Chem· December 2016

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Amending HIV Drugs: A Novel Small-Molecule Approach To Target Lupus Anti-DNA Antibodies.
Sonya VanPatten, Shan Sun, Mingzhu He, Kai Fan Cheng, Ahmad Altiti

J Med Chem· October 2016

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The cation channel Trpv2 is a new suppressor of arthritis severity, joint damage, and synovial fibroblast invasion.
Teresina Laragione, Kai F Cheng, Mark R Tanner, Mingzhu He, Christine Beeton

Clin Immunol· June 2015

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Xanomeline suppresses excessive pro-inflammatory cytokine responses through neural signal-mediated pathways and improves survival in lethal inflammation.
Mauricio Rosas-Ballina, Sergio I Valdés-Ferrer, Meghan E Dancho, Mahendar Ochani, David Katz, Kai Fan Cheng

Brain Behav Immun· February 2015

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A novel mechanism of B cell-mediated immune suppression through CD73 expression and adenosine production.
Hiroaki Kaku, Kai Fan Cheng, Yousef Al-Abed, Thomas L Rothstein

J Immunol· December 2014

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ISO-66, a novel inhibitor of macrophage migration, shows efficacy in melanoma and colon cancer models.
Kyriaki Ioannou, Kai Fan Cheng, Gregg V Crichlow, Anastasios I Birmpilis, Elias J Lolis

Int J Oncol· October 2014

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Novel arylazoarylmethane as potential inhibitor of macrophage migration inhibitory factor.
Mingzhu He, Christine Metz, Kai Fan Cheng, Jie Ling, Thomas Coleman

Arch Pharm (Weinheim)· February 2014

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Macrophage migration inhibitory factor mediates hypoxia-induced pulmonary hypertension.
Yinzhong Zhang, Arunabh Talwar, Donna Tsang, Annette Bruchfeld, Ali Sadoughi, Kai Fan Cheng

Mol Med· March 2012

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Inhibition of macrophage migration inhibitory factor reduces endometriotic implant size in mice with experimentally induced disease.
Warren B Nothnick, Arlene Colvin, Kai Fan Cheng, Yousef Al-Abed

J Endometr· September 2011

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Cytotoxic and immune-sensitizing properties of nitric oxide-modified Saquinavir in iNOS-positive human melanoma cells.
Sanja Mijatovic, Danijela Maksimovic-Ivanic, Marija Mojic, Gordana Timotijevic, Djordje Miljkovic, Kai Fan Cheng

J Cell Physiol· July 2011

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Generation of a unique small molecule peptidomimetic that neutralizes lupus autoantibody activity.
Ona Bloom, Kai Fan Cheng, Mingzhu He, Angelos Papatheodorou, Bruce T Volpe

Proc Natl Acad Sci U S A· June 2011

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Thyroxine is a potential endogenous antagonist of macrophage migration inhibitory factor (MIF) activity.
Yousef Al-Abed, Christine N Metz, Kai Fan Cheng, Bayan Aljabari, Sonya VanPatten

Proc Natl Acad Sci U S A· May 2011

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ISO-1, a macrophage migration inhibitory factor antagonist, inhibits airway remodeling in a murine model of chronic asthma.
Pei-Fen Chen, Ya-ling Luo, Wei Wang, Jiang-xin Wang, Wen-yan Lai, Kai Fan Cheng

Mol Med· December 2010

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The antitumor properties of a nontoxic, nitric oxide-modified version of saquinavir are independent of Akt.
Danijela Maksimovic-Ivanic, Sanja Mijatovic, Djordje Miljkovic, Ljubica Harhaji-Trajkovic, Gordana Timotijevic, Kai Fan Cheng

Mol Cancer Ther· May 2009

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Novel nitric oxide-donating compound (S,R)-3-phenyl-4,5-dihydro-5-isoxazole acetic acid-nitric oxide (GIT-27NO) induces p53 mediated apoptosis in human A375 melanoma cells.
Sanja Mijatovic, Danijela Maksimovic-Ivanic, Marija Mojic, Graziella Malaponte, Massimo Libra, Kai Fan Cheng

Nitric Oxide· September 2008

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Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor.
Gregg V Crichlow, Kai Fan Cheng, Darrin Dabideen, Mahendar Ochani, Bayan Aljabari

J Biol Chem· August 2007

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