Publications by authors named "Kalet Leon"

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Enhanced affinity for the IL-2 receptor β subunit potently increases antitumor efficacy of IL-2 across various tumor models by reshaping the tumor microenvironment.
Ernesto Relova-Hernández, Ana Beatriz Díaz-Bravo, Rodrigo Pedroso, Miguel Ángel Gonzalez-Cruz, Tania Gómez

J Immunol· November 2025

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Preclinical Evaluation of a Near-Infrared Labelled Antibody Targeting the Tumour Associated Xenoantigen N-Glycolyl-Neuraminic Acid GM3 Ganglioside.
Kris Barreto, Wendy Bernhard, Darien Toledo, Kimberly Jett, Angel Casaco

Mol Imaging Biol· August 2025

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Safety toxicology of an IL-2 'no-alpha' mutein in the Sprague-Dawley rat following repeated dosing via intravenous administration.
Gokulan Nagabaskaran, Aaron Thambiahpillay, Nuris Ledon, Richard Bagshaw, Sum Lai Lozada, Kalet Leon

Toxicol Rep· June 2025

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PEGylation Strategy for Improving the Pharmacokinetic and Antitumoral Activity of the IL-2 No-alpha Mutein.
Marianniz Díaz-Hernández, Janoi Chang-Calderón, Miguel Angel Álvarez, Ingrid Ruiz Ramírez, Olga Lidea Fernández Saez

Curr Pharm Des· January 2024

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NeuroEPO plus (NeuralCIM) in mild-to-moderate Alzheimer's clinical syndrome: the ATHENEA randomized clinical trial.
Saily Sosa, Giosmany Bringas, Nelky Urrutia, Ana Ivis Peñalver, Danay López

Alzheimers Res Ther· December 2023

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HEK293 producing the extracellular domain HER1: Full datasets of continuous fermentation process and metabolites analysis.
Lisandra Calzadilla, Erick Hernández, Julio Dustet, Jorge Fernandez-de-Cossio-Diaz, Kalet León

Data Brief· October 2023

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Molecular reshaping of phage-displayed Interleukin-2 at beta chain receptor interface to obtain potent super-agonists with improved developability profiles.
Gertrudis Rojas, Ernesto Relova-Hernández, Annia Pérez-Riverón, Camila Castro-Martínez, Osmany Diaz-Bravo

Commun Biol· August 2023

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Predicting a Stable Dimeric Form of the PD1-PDL1 Complex: Implications for Understanding the PD1 Activation Mechanism.
Luis F Ponce, Daniel P Ramírez-Echemendia, Kalet León, Pedro A Valiente

J Phys Chem B· July 2023

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Potent immunomodulatory and antitumor effect of anti-CD20-IL2no-alpha tri-functional immunocytokine for cancer therapy.
Ana Victoria Casadesús, Beatriz María Cruz, Wilden Díaz, Miguel Ángel González, Tania Gómez

Front Immunol· December 2022

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The antitumor effect induced by an IL-2 'no-alpha' mutein depends on changes in the CD8 T lymphocyte/Treg cell balance.
Tania Carmenate, Galia Montalvo, Sum Lai Lozada, Yaretnis Rodriguez, Yaquelin Ortiz

Front Immunol· September 2022

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Augmenting antibody response to EGF-depleting immunotherapy: Findings from a phase I trial of CIMAvax-EGF in combination with nivolumab in advanced stage NSCLC.
Rachel Evans, Kelvin Lee, Paul K Wallace, Mary Reid, Jason Muhitch, Kalet Leon

Front Oncol· August 2022

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Unraveling a Conserved Conformation of the FG Loop upon the Binding of Natural Ligands to the Human and Murine PD1.
Luis F Ponce, Kalet Leon, Pedro A Valiente

J Phys Chem B· February 2022

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SARS-CoV-2 RBD-Tetanus Toxoid Conjugate Vaccine Induces a Strong Neutralizing Immunity in Preclinical Studies.
Yury Valdes-Balbin, Darielys Santana-Mederos, Lauren Quintero, Sonsire Fernández, Laura Rodriguez

ACS Chem Biol· July 2021

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In-silico media optimization for continuous cultures using genome scale metabolic networks: The case of CHO-K1.
Bárbara A Pérez-Fernández, Jorge Fernandez-de-Cossio-Diaz, Tammy Boggiano, Kalet León, Roberto Mulet

Biotechnol Bioeng· May 2021

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Molecular Aspects Concerning the Use of the SARS-CoV-2 Receptor Binding Domain as a Target for Preventive Vaccines.
Yury Valdes-Balbin, Darielys Santana-Mederos, Françoise Paquet, Sonsire Fernandez, Yanet Climent, Kalet Leon

ACS Cent Sci· May 2021

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Differential Effects of IL2Rα and IL15Rα over the Stability of the Common Beta-Gamma Signaling Subunits of the IL2 and IL15 Receptors.
Luis F Ponce, Galia Montalvo, Kalet Leon, Pedro A Valiente

J Chem Inf Model· April 2021

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An anti-CD6 antibody for the treatment of COVID-19 patients with cytokine-release syndrome: report of three cases.
Lázaro Manuel Filgueira, Julio Betancourt Cervantes, Orlando Adolfo Lovelle, Carlos Herrera, Carlos Figueredo, Kalet Leon

Immunotherapy· March 2021

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Exploring the conformational dynamics of PD1 in complex with different ligands: What we can learn for designing novel PD1 signaling blockers?
Luis F Ponce, Karina García-Martínez, Kalet León, Pedro A Valiente

Proteins· February 2021

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Use of a Humanized Anti-CD6 Monoclonal Antibody (Itolizumab) in Elderly Patients with Moderate COVID-19.
Yayquier Díaz, Mayra Ramos-Suzarte, Yordanis Martín, Néstor Antonio Calderón, William Santiago, Kalet Leon

Gerontology· December 2020

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An anti-CD6 monoclonal antibody (itolizumab) reduces circulating IL-6 in severe COVID-19 elderly patients.
Danay Saavedra, Ana Laura Añé-Kourí, Naivy Sánchez, Lázaro Manuel Filgueira, Julio Betancourt

Immun Ageing· November 2020

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Treatment of COVID-19 patients with the anti-CD6 antibody itolizumab.
Armando Caballero, Lázaro M Filgueira, Julio Betancourt, Naivy Sánchez, Carlos Hidalgo

Clin Transl Immunology· November 2020

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A rationally-engineered IL-2 improves the antitumor effect of anti-CD20 therapy.
Ana Victoria Casadesús, Claire Deligne, Béré Kadjdiatou Diallo, Katya Sosa, Nathalie Josseaume

Oncoimmunology· June 2020

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Quantitative assessment of extracellular IL-1 regulation.
Luis F Ponce, Karina García-Martínez, Kalet León

J Theor Biol· February 2020

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Modulation of CD4 T cell function via CD6-targeting.
Raquel Filipa Freitas, Afonso Basto, Silvia C P Almeida, Rita F Santos, Carine M Gonçalves, Kalet Leon

EBioMedicine· September 2019

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Directed evolution of super-secreted variants from phage-displayed human Interleukin-2.
Gertrudis Rojas, Tania Carmenate, Julio Felipe Santo-Tomás, Pedro A Valiente, Marlies Becker

Sci Rep· January 2019

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