Publications by authors named "Karen Sims"

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Preclinical and clinical antiviral characterization of AB-836, a potent capsid assembly modulator against hepatitis B virus.
Angela M Lam, Nagraj Mani, Andrzej Ardzinski, Kim Stever, Andrea Cuconati, Karen D Sims

Antiviral Res· November 2024

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A national assessment of standards of care for inherited bleeding disorders in Canada.
David Page, Sarah Crymble, Lawrence Jardine, JoAnn Nilson, Kathy Mulder, Karen Sims

Haemophilia· November 2023

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Safety, pharmacokinetics, and antiviral activity of the capsid inhibitor AB-506 from Phase 1 studies in healthy subjects and those with hepatitis B.
Man-Fung Yuen, Elina Berliba, Wattana Sukeepaisarnjaroen, Sang Hoon Ahn, Tawesak Tanwandee, Karen D Sims

Hepatol Commun· December 2022

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Correction for Saha et al., "Epstein-Barr Virus Nuclear Antigen 3C Augments Mdm2-Mediated p53 Ubiquitination and Degradation by Deubiquitinating Mdm2".
Abhik Saha, Masanao Murakami, Pankaj Kumar, Bharat Bajaj, Karen Sims

J Virol· August 2021

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Effects of a Fixed-Dose Co-Formulation of Daclatasvir, Asunaprevir, and Beclabuvir on the Pharmacokinetics of a Cocktail of Cytochrome P450 and Drug Transporter Substrates in Healthy Subjects.
Tushar Garimella, Xiaolu Tao, Karen Sims, Yi-Ting Chang, Jignasa Rana

Drugs R D· March 2018

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CYP2C19 Genotype-Dependent Pharmacokinetic Drug Interaction Between Voriconazole and Ritonavir-Boosted Atazanavir in Healthy Subjects.
Li Zhu, Roger J Brüggemann, Jonathan Uy, Angela Colbers, Matthew W Hruska, Karen Sims

J Clin Pharmacol· February 2017

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A randomized trial in healthy subjects to assess the bioequivalence of an atazanavir/cobicistat fixed-dose combination tablet versus administration as separate agents.
Heather Sevinsky, Xiaolu Tao, Reena Wang, Palanikumar Ravindran, Karen Sims

Antivir Ther· May 2016

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Daclatasvir + asunaprevir + beclabuvir ± ribavirin for chronic HCV genotype 1-infected treatment-naive patients.
Gregory T Everson, Karen D Sims, Paul J Thuluvath, Eric Lawitz, Tarek Hassanein

Liver Int· February 2016

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NS5A Sequence Heterogeneity and Mechanisms of Daclatasvir Resistance in Hepatitis C Virus Genotype 4 Infection.
Nannan Zhou, Dennis Hernandez, Joseph Ueland, Xiaoyan Yang, Fei Yu, Karen Sims

J Infect Dis· January 2016

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A randomized trial of daclatasvir in combination with asunaprevir and beclabuvir in patients with chronic hepatitis C virus genotype 4 infection.
Tarek Hassanein, Karen D Sims, Michael Bennett, Norman Gitlin, Eric Lawitz

J Hepatol· May 2015

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Randomized, placebo-controlled, single-ascending-dose study of BMS-791325, a hepatitis C virus (HCV) NS5B polymerase inhibitor, in HCV genotype 1 infection.
Karen D Sims, Julie Lemm, Timothy Eley, Menping Liu, Anna Berglind

Antimicrob Agents Chemother· June 2014

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Efficacy of an interferon- and ribavirin-free regimen of daclatasvir, asunaprevir, and BMS-791325 in treatment-naive patients with HCV genotype 1 infection.
Gregory T Everson, Karen D Sims, Maribel Rodriguez-Torres, Christophe Hézode, Eric Lawitz

Gastroenterology· February 2014

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A rare chromosome 3 imbalance and its clinical implications.
Karen Sims, Roberto L P Mazzaschi, Emilie Payne, Ian Hayes, Donald R Love

Case Rep Pediatr· October 2012

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Effect of single vs bilateral lung transplantation on plasma surfactant protein D levels in idiopathic pulmonary fibrosis.
Michael W Sims, Michael F Beers, Vivek N Ahya, Steven M Kawut, Karen D Sims

Chest· August 2011

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Common infections in the lung transplant recipient.
Karen D Sims, Emily A Blumberg

Clin Chest Med· June 2011

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Why did passion wane? A qualitative study of married women's attributions for declines in sexual desire.
Karen E Sims, Marta Meana

J Sex Marital Ther· February 2011

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Targeting choroid plexus epithelia and ventricular ependyma for drug delivery to the central nervous system.
Ana Maria Gonzalez, Wendy E Leadbeater, Michael Burg, Karen Sims, Tetsuya Terasaki

BMC Neurosci· January 2011

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Epidermal growth factor targeting of bacteriophage to the choroid plexus for gene delivery to the central nervous system via cerebrospinal fluid.
Ana Maria Gonzalez, Wendy Leadbeater, Sonia Podvin, Alexandra Borboa, Michael Burg, Karen Sims

Brain Res· November 2010

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The deployment of adenovirus-containing gene activated matrices onto severed axons after central nervous system injury leads to transgene expression in target neuronal cell bodies.
Ana Maria Gonzalez, Oscar Berlanga, Wendy E Leadbeater, Lisa Cooper-Charles, Karen Sims

J Gene Med· August 2009

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Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
Abhik Saha, Masanao Murakami, Pankaj Kumar, Bharat Bajaj, Karen Sims

J Virol· May 2009

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In vitro evaluation of a 'stealth' adenoviral vector for targeted gene delivery to adult mammalian neurones.
Karen Sims, Zubair Ahmed, Martin L Read, Lisa Cooper-Charles, Ana Maria Gonzalez

J Gene Med· April 2009

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Targeting adenoviral transgene expression to neurons.
Karen Sims, Zubair Ahmed, Ana Maria Gonzalez, Martin L Read, Lisa Cooper-Charles

Mol Cell Neurosci· November 2008

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Separation anxiety disorder in young children: a longitudinal and family analysis.
Christopher A Kearney, Karen E Sims, Courtney R Pursell, Cheryl A Tillotson

J Clin Child Adolesc Psychol· December 2003

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