Publications by authors named "Karl A Walter"

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In silico high throughput mutagenesis and screening of signal peptides to mitigate N-terminal heterogeneity of recombinant monoclonal antibodies.
Xin Yu, Merlinda Conyne, Marc R Lake, Karl A Walter, Jing Min

MAbs· April 2022

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Ligand association rates to the inner-variable-domain of a dual-variable-domain immunoglobulin are significantly impacted by linker design.
Enrico L Digiammarino, John E Harlan, Karl A Walter, Uri S Ladror, Rohinton P Edalji

MAbs· March 2012

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Expression and purification of human TRPV1 in baculovirus-infected insect cells for structural studies.
Alla Korepanova, Ana Pereda-Lopez, Larry R Solomon, Karl A Walter, Marc R Lake

Protein Expr Purif· May 2009

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Toxicological evaluation of thiol-reactive compounds identified using a la assay to detect reactive molecules by nuclear magnetic resonance.
Jeffrey R Huth, Danying Song, Renaldo R Mendoza, Candice L Black-Schaefer, Jamey C Mack, Karl A Walter

Chem Res Toxicol· December 2007

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Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies.
Jeffrey R Huth, Chang Park, Andrew M Petros, Aaron R Kunzer, Michael D Wendt, Karl A Walter

Chem Biol Drug Des· July 2007

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From bacterial genomes to novel antibacterial agents: discovery, characterization, and antibacterial activity of compounds that bind to HI0065 (YjeE) from Haemophilus influenzae.
Claude G Lerner, Philip J Hajduk, Rolf Wagner, Frank L Wagenaar, Charlotte Woodall, Karl A Walter

Chem Biol Drug Des· June 2007

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Design and characterization of an engineered gp41 protein from human immunodeficiency virus-1 as a tool for drug discovery.
Kent D Stewart, Kevin Steffy, Kevin Harris, John E Harlan, Vincent S Stoll, Karl A Walter

J Comput Aided Mol Des· May 2007

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Activation of TRPA1 channels by the fatty acid amide hydrolase inhibitor 3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate (URB597).
Wende Niforatos, Xu-Feng Zhang, Marc R Lake, Karl A Walter, Torben Neelands

Mol Pharmacol· May 2007

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Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS.
Chaohong Sun, Danying Song, Rachel A Davis-Taber, Leo W Barrett, Victoria E Scott, Karl A Walter

Proc Natl Acad Sci U S A· May 2007

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Utility of large-scale transiently transfected cells for cell-based high-throughput screens to identify transient receptor potential channel A1 (TRPA1) antagonists.
Jun Chen, Marc R Lake, Reza S Sabet, Wende Niforatos, Steve D Pratt, Karl A Walter

J Biomol Screen· February 2007

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Structure of MurF from Streptococcus pneumoniae co-crystallized with a small molecule inhibitor exhibits interdomain closure.
Kenton L Longenecker, Geoffrey F Stamper, Philip J Hajduk, Elizabeth H Fry, Clarissa G Jakob, Karl A Walter

Protein Sci· December 2005

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Kringle 5 of human plasminogen induces apoptosis of endothelial and tumor cells through surface-expressed glucose-regulated protein 78.
Don J Davidson, Catherine Haskell, Sandy Majest, Abdullah Kherzai, David A Egan, Karl A Walter

Cancer Res· June 2005

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Discovery of potent inhibitors of dihydroneopterin aldolase using CrystaLEAD high-throughput X-ray crystallographic screening and structure-directed lead optimization.
William J Sanders, Vicki L Nienaber, Claude G Lerner, J Owen McCall, Sean M Merrick, Karl A Walter

J Med Chem· March 2004

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