Publications by authors named "Karl Brendel"

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The Evolving Role of In Vitro-In Vivo Correlation in Model-Informed Drug Development: A Multi-Stakeholder Perspective.
Marylore Chenel, Sylvain Fouliard, Emma Hansson, Karl Brendel, Matthieu Jacobs

CPT Pharmacometrics Syst Pharmacol· December 2025

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Using Fisher Information Matrix to predict uncertainty in covariate effects and power to detect their relevance in Non-Linear Mixed Effect Models in pharmacometrics.
Lucie Fayette, Karl Brendel, France Mentré

J Pharmacokinet Pharmacodyn· July 2025

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Population pharmacokinetics of liposomal irinotecan in patients with cancer and exposure-safety analyses in patients with metastatic pancreatic cancer.
Karl Brendel, Tanios Bekaii-Saab, Patrick M Boland, Farshid Dayyani, Andrew Dean

CPT Pharmacometrics Syst Pharmacol· December 2021

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First-in-human phase I study of oral S49076, a unique MET/AXL/FGFR inhibitor, in advanced solid tumours.
Jordi Rodon, Sophie Postel-Vinay, Antoine Hollebecque, Paolo Nuciforo, Analia Azaro, Karl Brendel

Eur J Cancer· August 2017

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Model-based approaches for ivabradine development in paediatric population, part I: study preparation assessment.
Sophie Peigné, François Bouzom, Karl Brendel, Charlotte Gesson, Sylvain Fouliard

J Pharmacokinet Pharmacodyn· February 2016

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Optimal sampling times for a drug and its metabolite using SIMCYP(®) simulations as prior information.
Cyrielle Dumont, France Mentré, Clare Gaynor, Karl Brendel, Charlotte Gesson

Clin Pharmacokinet· January 2013

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Why should prediction discrepancies be renamed standardized visual predictive check?
Emmanuelle Comets, Karl Brendel, France Mentré

J Clin Pharmacol· August 2012

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Evaluation of different tests based on observations for external model evaluation of population analyses.
Karl Brendel, Emmanuelle Comets, Céline Laffont, France Mentré

J Pharmacokinet Pharmacodyn· February 2010

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Computing normalised prediction distribution errors to evaluate nonlinear mixed-effect models: the npde add-on package for R.
Emmanuelle Comets, Karl Brendel, France Mentré

Comput Methods Programs Biomed· May 2008

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Are population pharmacokinetic and/or pharmacodynamic models adequately evaluated? A survey of the literature from 2002 to 2004.
Karl Brendel, Céline Dartois, Emmanuelle Comets, Annabelle Lemenuel-Diot, Christian Laveille

Clin Pharmacokinet· April 2007

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Metrics for external model evaluation with an application to the population pharmacokinetics of gliclazide.
Karl Brendel, Emmanuelle Comets, Céline Laffont, Christian Laveille, France Mentré

Pharm Res· September 2006

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Absence of association between MDR1 genetic polymorphisms, indinavir pharmacokinetics and response to highly active antiretroviral therapy.
Céline Verstuyft, Fabienne Marcellin, Laurence Morand-Joubert, Odile Launay, Karl Brendel

AIDS· December 2005

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Population pharmacokinetic analysis of indinavir in HIV-infected patient treated with a stable antiretroviral therapy.
Karl Brendel, Mayeule Legrand, Anne-Marie Taburet, Gabriel Baron, Cécile Goujard

Fundam Clin Pharmacol· June 2005

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