Publications by authors named "Marylore Chenel"

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The Evolving Role of In Vitro-In Vivo Correlation in Model-Informed Drug Development: A Multi-Stakeholder Perspective.
Marylore Chenel, Sylvain Fouliard, Emma Hansson, Karl Brendel, Matthieu Jacobs

CPT Pharmacometrics Syst Pharmacol· December 2025

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Harnessing Open-Source Solutions: Insights From the First Open Systems Pharmacology (OSP) Community Conference.
André Dallmann, Denise Feick, Pavel Balazki, Salih Benamara, Rolf Burghaus, Marylore Chenel

CPT Pharmacometrics Syst Pharmacol· May 2025

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Model-Informed Drug Development of a Sustained Release Formulation of Flucytosine in the Treatment of Cryptococcal Meningitis: A Case Study Using Physiologically Based Pharmacokinetic Modeling.
Johanna Eriksson, Erik Sjögren, Jean-Yves Gillon, Henri Caplain, Vishal Goyal, Marylore Chenel

CPT Pharmacometrics Syst Pharmacol· April 2025

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Bioavailability of a novel sustained-release pellet formulation of 5-flucytosine in healthy-fed participants for use in patients with cryptococcal meningitis.
Nabila Ibnou Zekri Lassout, Vishal Goyal, Edrich Krantz, Francois Simon, Anouk Neven, Marylore Chenel

Clin Transl Sci· September 2024

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Bioavailability of three novel oral, sustained-release pellets, relative to an immediate-release tablet containing 500 mg flucytosine: A randomized, open-label, crossover study in healthy volunteers.
Vishal Goyal, Edrich Krantz, Francois Simon, Anouk Neven, Johanna Eriksson, Marylore Chenel

Clin Transl Sci· March 2024

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Virtual patients, digital twins and causal disease models: Paving the ground for in silico clinical trials.
Philippe Moingeon, Marylore Chenel, Cécile Rousseau, Emmanuelle Voisin, Mickael Guedj

Drug Discov Today· July 2023

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How to Successfully Generate an Alternative Approach to a Thorough QT Study: GLPG1972 as an Example.
Claudia Meyer, Ines Dierick, Glenn Gauderat, Jurgen Langenhorst, Céline Sarr, Marylore Chenel

Clin Pharmacol Ther· February 2023

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Mechanistic Modeling of the Interplay Between Host Immune System, IL-7 and UCART19 Allogeneic CAR-T Cells in Adult B-cell Acute Lymphoblastic Leukemia.
Thibaud Derippe, Sylvain Fouliard, Ibtissam Marchiq, Sandra Dupouy, Maria Almena-Carrasco, Marylore Chenel

Cancer Res Commun· November 2022

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Modeling restoration of gefitinib efficacy by co-administration of MET inhibitors in an EGFR inhibitor-resistant NSCLC xenograft model: A tumor-in-host DEB-based approach.
Elena M Tosca, Glenn Gauderat, Sylvain Fouliard, Mike Burbridge, Marylore Chenel

CPT Pharmacometrics Syst Pharmacol· November 2021

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Reduced physiologically-based pharmacokinetic model of dabigatran etexilate-dabigatran and its application for prediction of intestinal P-gp-mediated drug-drug interactions.
Jennifer Lang, Ludwig Vincent, Marylore Chenel, Kayode Ogungbenro, Aleksandra Galetin

Eur J Pharm Sci· October 2021

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Impact of Hepatic CYP3A4 Ontogeny Functions on Drug-Drug Interaction Risk in Pediatric Physiologically-Based Pharmacokinetic/Pharmacodynamic Modeling: Critical Literature Review and Ivabradine Case Study.
Jennifer Lang, Ludwig Vincent, Marylore Chenel, Kayode Ogungbenro, Aleksandra Galetin

Clin Pharmacol Ther· June 2021

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Impact of interleukin-6 on drug transporters and permeability in the hCMEC/D3 blood-brain barrier model.
Florian Simon, Laetitia Guyot, Jessica Garcia, Gaelle Vilchez, Claire Bardel, Marylore Chenel

Fundam Clin Pharmacol· April 2021

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Quantitative Systems Pharmacology Approaches for Immuno-Oncology: Adding Virtual Patients to the Development Paradigm.
Vijayalakshmi Chelliah, Georgia Lazarou, Sumit Bhatnagar, John P Gibbs, Marjoleen Nijsen, Marylore Chenel

Clin Pharmacol Ther· March 2021

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Modeling Approach to Predict the Impact of Inflammation on the Pharmacokinetics of CYP2C19 and CYP3A4 Substrates.
Florian Simon, Elodie Gautier-Veyret, Aurélie Truffot, Marylore Chenel, Léa Payen

Pharm Res· March 2021

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Translational approach from preclinical to clinical: comparison of dose finding methods of a new Bcl2 inhibitor using PK-PD modeling and interspecies extrapolation.
Philippe B Pierrillas, Emilie Henin, Julien Ogier, Magali Amiel, Laurence Kraus-Berthier, Marylore Chenel

Invest New Drugs· December 2020

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Simultaneous Ivabradine Parent-Metabolite PBPK/PD Modelling Using a Bayesian Estimation Method.
Jennifer Lang, Ludwig Vincent, Marylore Chenel, Kayode Ogungbenro, Aleksandra Galetin

AAPS J· October 2020

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Transforming Translation Through Quantitative Pharmacology for High-Impact Decision Making in Drug Discovery and Development.
Neeraj Gupta, Dean Bottino, Ulrika S H Simonsson, Cynthia J Musante, Tjerk Bueters, Marylore Chenel

Clin Pharmacol Ther· June 2020

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Impact of Interleukin-6 on Drug-Metabolizing Enzymes and Transporters in Intestinal Cells.
Florian Simon, Jessica Garcia, Laetitia Guyot, Jérôme Guitton, Gaelle Vilchez, Marylore Chenel

AAPS J· December 2019

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Application of Item Response Theory to Model Disease Progression and Agomelatine Effect in Patients with Major Depressive Disorder.
Marc Cerou, Sophie Peigné, Emmanuelle Comets, Marylore Chenel

AAPS J· November 2019

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Prediction of Human Nonlinear Pharmacokinetics of a New Bcl-2 Inhibitor Using PBPK Modeling and Interspecies Extrapolation Strategy.
Philippe B Pierrillas, Emilie Henin, Kathryn Ball, Julien Ogier, Magali Amiel, Marylore Chenel

Drug Metab Dispos· June 2019

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Tumor Growth Inhibition Modelling Based on Receptor Occupancy and Biomarker Activity of a New Bcl-2 Inhibitor in Mice.
Philippe B Pierrillas, Emilie Henin, Julien Ogier, Laurence Kraus-Berthier, Marylore Chenel

J Pharmacol Exp Ther· December 2018

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Integrated Pharmacokinetic/Pharmacodynamic Model of a Bispecific CD3xCD123 DART Molecule in Nonhuman Primates: Evaluation of Activity and Impact of Immunogenicity.
Olivia Campagne, Audrey Delmas, Sylvain Fouliard, Marylore Chenel, Gurunadh R Chichili

Clin Cancer Res· June 2018

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Getting Innovative Therapies Faster to Patients at the Right Dose: Impact of Quantitative Pharmacology Towards First Registration and Expanding Therapeutic Use.
Satyaprakash Nayak, Oliver Sander, Nidal Al-Huniti, Dinesh de Alwis, Anne Chain, Marylore Chenel

Clin Pharmacol Ther· March 2018

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Model-Based Adaptive Optimal Design (MBAOD) Improves Combination Dose Finding Designs: an Example in Oncology.
Philippe B Pierrillas, Sylvain Fouliard, Marylore Chenel, Andrew C Hooker, Lena E Friberg

AAPS J· March 2018

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Correction to: Model-Based Adaptive Optimal Design (MBAOD) Improves Combination Dose Finding Designs: an Example in Oncology.
Philippe B Pierrillas, Sylvain Fouliard, Marylore Chenel, Andrew C Hooker, Lena E Friberg

AAPS J· March 2018

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