Publications by authors named "Karl J Box"

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Predictions of biorelevant solubility change during dispersion and digestion of lipid-based formulations.
Lotte Ejskjær, René Holm, Martin Kuentz, Karl J Box, Brendan T Griffin

Eur J Pharm Sci· September 2024

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Developing an in vitro lipolysis model for real-time analysis of drug concentrations during digestion of lipid-based formulations.
Lotte Ejskjær, Patrick J O'Dwyer, Callum D Ryan, René Holm, Martin Kuentz, Karl J Box

Eur J Pharm Sci· March 2024

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On the usefulness of four in vitro methods in assessing the intraluminal performance of poorly soluble, ionisable compounds in the fasted state.
Patrick J O'Dwyer, Karl J Box, Georgios Imanidis, Maria Vertzoni, Christos Reppas

Eur J Pharm Sci· January 2022

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Oral biopharmaceutics tools: recent progress from partnership through the Pharmaceutical Education and Research with Regulatory Links collaboration.
Patrick J O'Dwyer, Karl J Box, Jennifer Dressman, Brendan T Griffin, Laura J Henze

J Pharm Pharmacol· March 2021

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Applying Computational Predictions of Biorelevant Solubility Ratio Upon Self-Emulsifying Lipid-Based Formulations Dispersion to Predict Dose Number.
Harriet Bennett-Lenane, Niklas J Koehl, Patrick J O'Dwyer, Karl J Box, Joseph P O'Shea

J Pharm Sci· January 2021

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Novel Biphasic Lipolysis Method To Predict Performance of Lipid-Based Formulations.
Patrick J O'Dwyer, Karl J Box, Niklas J Koehl, Harriet Bennett-Lenane, Christos Reppas

Mol Pharm· September 2020

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Combining biorelevant in vitro and in silico tools to investigate the in vivo performance of the amorphous solid dispersion formulation of etravirine in the fed state.
Chara Litou, David B Turner, Nico Holmstock, Jens Ceulemans, Karl J Box

Eur J Pharm Sci· June 2020

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On the Usefulness of Two Small-Scale In Vitro Setups in the Evaluation of Luminal Precipitation of Lipophilic Weak Bases in Early Formulation Development.
Patrick J O'Dwyer, Georgios Imanidis, Karl J Box, Christos Reppas

Pharmaceutics· March 2020

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Combining biorelevant in vitro and in silico tools to simulate and better understand the in vivo performance of a nano-sized formulation of aprepitant in the fasted and fed states.
Chara Litou, Nikunjkumar Patel, David B Turner, Edmund Kostewicz, Martin Kuentz, Karl J Box

Eur J Pharm Sci· October 2019

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Biphasic drug release testing coupled with diffusing wave spectroscopy for mechanistic understanding of solid dispersion performance.
Sandra Jankovic, Patrick J O'Dwyer, Karl J Box, Georgios Imanidis, Christos Reppas

Eur J Pharm Sci· September 2019

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In vitro methods to assess drug precipitation in the fasted small intestine - a PEARRL review.
Patrick J O'Dwyer, Chara Litou, Karl J Box, Jennifer B Dressman, Edmund S Kostewicz

J Pharm Pharmacol· April 2019

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Effects of medicines used to treat gastrointestinal diseases on the pharmacokinetics of coadministered drugs: a PEARRL Review.
Chara Litou, Angela Effinger, Edmund S Kostewicz, Karl J Box, Nikoletta Fotaki

J Pharm Pharmacol· April 2019

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Small-Scale Assays for Studying Dissolution of Pharmaceutical Cocrystals for Oral Administration.
Karl J Box, John Comer, Robert Taylor, Shyam Karki, Rebeca Ruiz

AAPS PharmSciTech· April 2016

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pH-Dependent Liquid-Liquid Phase Separation of Highly Supersaturated Solutions of Weakly Basic Drugs.
Anura S Indulkar, Karl J Box, Robert Taylor, Rebeca Ruiz, Lynne S Taylor

Mol Pharm· July 2015

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pH-Induced precipitation behavior of weakly basic compounds: determination of extent and duration of supersaturation using potentiometric titration and correlation to solid state properties.
Yi-Ling Hsieh, Grace A Ilevbare, Bernard Van Eerdenbrugh, Karl J Box, Manuel Vincente Sanchez-Felix

Pharm Res· October 2012

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Study of pH-dependent solubility of organic bases. Revisit of Henderson-Hasselbalch relationship.
Gergely Völgyi, Edit Baka, Karl J Box, John E A Comer, Krisztina Takács-Novák

Anal Chim Acta· July 2010

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The chemistry of multi-protic drugs Part 1: a potentiometric, multi-wavelength UV and NMR pH titrimetric study of the micro-speciation of SKI-606.
Karl J Box, Rachel E Donkor, Philip A Jupp, Ian P Leader, David F Trew

J Pharm Biomed Anal· June 2008

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Diclofenac solubility: independent determination of the intrinsic solubility of three crystal forms.
Antonio Llinàs, Jonathan C Burley, Karl J Box, Robert C Glen, Jonathan M Goodman

J Med Chem· March 2007

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Equilibrium versus kinetic measurements of aqueous solubility, and the ability of compounds to supersaturate in solution--a validation study.
Karl J Box, Gergely Völgyi, Edit Baka, Martin Stuart, Krisztina Takács-Novák

J Pharm Sci· June 2006

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