Publications by authors named "Christos Reppas"

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In vitro evaluation of drug presence in the upper small intestine when antro-duodenal drug transfer of a highly permeable drug occurs after a high-calorie, high-fat meal.
Shirin Dietrich, Spyridoula Karagianni, Jens Ceulemans, Eline Hermans, Jan Bevernage, Christos Reppas

Eur J Pharm Sci· September 2025

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Corrigendum to "Characteristics of contents in the upper gastrointestinal lumen after a standard high-calorie high-fat meal and implications for the in vitro drug product performance testing conditions" [Eur J Pharm Sci. 155 (2020) 105535].
Christina Pentafragka, Maria Vertzoni, Jennifer Dressman, Mira Symillides, Konstantinos Goumas, Christos Reppas

Eur J Pharm Sci· September 2025

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Screening adsorbents for the prevention of drug-induced intestinal dysbiosis at pre-formulation stage: case example activated charcoal.
Lea Gnatzy, Dimitrios-Marios Katsikis, Konstantinos Papandreou, George Ismailos, Maria Vertzoni, Christos Reppas

J Pharm Pharmacol· September 2025

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Corrigendum to 'Understanding the conditions under which drugs are transferred from the stomach through the upper small intestine after a high-calorie, high-fat meal' Journal of Pharmaceutical Sciences/ Volume 113, Issue 6, June 2024, Pages 1546-1554.
Shirin Dietrich, Jens Ceulemans, Eline Hermans, Theodoros Argyropoulos, Konstantinos Goumas, Christos Reppas

J Pharm Sci· August 2025

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Simulation of Antral Conditions for Estimating Drug Apparent Equilibrium Solubility after a High-Calorie, High-Fat Meal.
Christos Reppas, Christina Chorianopoulou, Ioanna Karkaletsi, Shirin Dietrich, Andriani Bakolia

Mol Pharm· February 2025

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The effect of propranolol on gastrointestinal motility and permeability in patients with cirrhosis and significant portal hypertension.
Elias Xirouchakis, Hariklia Kranidioti, Emilia Hadziyanni, Anastasia Kourikou, Christos Reppas

BMC Gastroenterol· November 2024

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On the processes limiting oral drug absorption when amorphous solid dispersions are administered after a high-calorie, high-fat meal: Sporanox® pellets.
Shirin Dietrich, Myrto Dimoula, Theodoros Argyropoulos, Jens Ceulemans, Konstantinos Goumas, Christos Reppas

Eur J Pharm Sci· August 2024

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Understanding the Conditions Under Which Drugs are Transferred from the Stomach Through the Upper Small Intestine After a High-Calorie, High-Fat Meal.
Shirin Dietrich, Jens Ceulemans, Eline Hermans, Theodoros Argyropoulos, Konstantinos Goumas, Christos Reppas

J Pharm Sci· June 2024

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Drug Dissolution in Oral Drug Absorption: Workshop Report.
Kimberly Raines, Payal Agarwal, Patrick Augustijns, Alaadin Alayoubi, Lucas Attia, Christos Reppas

AAPS J· November 2023

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Leveraging the use of in vitro and computational methods to support the development of enabling oral drug products: An InPharma commentary.
Christos Reppas, Martin Kuentz, Annette Bauer-Brandl, Sara Carlert, André Dallmann

Eur J Pharm Sci· September 2023

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Managing the clinical effects of drug-induced intestinal dysbiosis with a focus to antibiotics: Challenges and opportunities.
Lea Gnatzy, George Ismailos, Maria Vertzoni, Christos Reppas

Eur J Pharm Sci· September 2023

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Screening for Differences in Early Exposure in the Fasted State with in Vitro Methodologies can be Challenging: Experience with the BioGIT System.
Christina Kostantini, Evanthia Spilioti, Jan Bevernage, Jens Ceulemans, Simone Hansmann, Christos Reppas

J Pharm Sci· August 2023

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The impact of advanced age on gastrointestinal characteristics that are relevant to oral drug absorption: An AGePOP review.
Cordula Stillhart, Adam Asteriadis, Ekaterina Bocharova, Gabriel Eksteen, Fritz Harder, Christos Reppas

Eur J Pharm Sci· August 2023

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Usefulness of the Beagle Model in the Evaluation of Paracetamol and Ibuprofen Exposure after Oral Administration to Pediatric Populations: An Exploratory Study.
Marina Statelova, René Holm, Nikoletta Fotaki, Christos Reppas, Maria Vertzoni

Mol Pharm· June 2023

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Usefulness of the BioGIT system in screening for differences in early exposure in the fasted state on an a priori basis.
Christina Kostantini, Evanthia Spilioti, Jan Bevernage, Jens Ceulemans, Simone Hansmann, Christos Reppas

Int J Pharm· March 2023

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Usefulness of Optimized Human Fecal Material in Simulating the Bacterial Degradation of Sulindac and Sulfinpyrazone in the Lower Intestine.
Christina Kostantini, Sumit Arora, Erik Söderlind, Jens Ceulemans, Christos Reppas

Mol Pharm· July 2022

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Integration of advanced methods and models to study drug absorption and related processes: An UNGAP perspective.
Clive G Wilson, Leon Aarons, Patrick Augustijns, Joachim Brouwers, Adam S Darwich, Christos Reppas

Eur J Pharm Sci· May 2022

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On the usefulness of four in vitro methods in assessing the intraluminal performance of poorly soluble, ionisable compounds in the fasted state.
Patrick J O'Dwyer, Karl J Box, Georgios Imanidis, Maria Vertzoni, Christos Reppas

Eur J Pharm Sci· January 2022

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In Vitro Simulation of the Environment in the Upper Gastrointestinal Lumen After Drug Administration in the Fed State Using the TIM-1 System and Comparison With Luminal Data in Adults.
Christina Pentafragka, Irena Tomaszewska, Susann Bellmann, Mans Minekus, Ronald Schilderink, Christos Reppas

J Pharm Sci· January 2022

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Jennifer Dressman - 40 years of Oral Drug Absorption.
Bertil Abrahamsson, James Butler, Rodrigo Cristofoletti, Edmund Kostewicz, Christoph Saal, Christos Reppas

J Pharm Sci· January 2022

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Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: An UNGAP review.
Zahari Vinarov, Mohammad Abdallah, José A G Agundez, Karel Allegaert, Abdul W Basit, Christos Reppas

Eur J Pharm Sci· July 2021

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Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network.
Zahari Vinarov, Bertil Abrahamsson, Per Artursson, Hannah Batchelor, Philippe Berben, Christos Reppas

Adv Drug Deliv Rev· April 2021

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Oral biopharmaceutics tools: recent progress from partnership through the Pharmaceutical Education and Research with Regulatory Links collaboration.
Patrick J O'Dwyer, Karl J Box, Jennifer Dressman, Brendan T Griffin, Laura J Henze, Christos Reppas

J Pharm Pharmacol· March 2021

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Characteristics of Contents of Lower intestine in the 65-74 Years of Age Range Could Impact the Performance of Safe and Efficacious Modified Release Products.
Maria Vertzoni, Sarah Sulaiman, Konstantinos Goumas, Elisabeth Kersten, Johanna Anlahr, Christos Reppas

J Pharm Sci· January 2021

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Factors Affecting Successful Extrapolation of Ibuprofen Exposure from Adults to Pediatric Populations After Oral Administration of a Pediatric Aqueous Suspension.
Marina Statelova, René Holm, Nikoletta Fotaki, Christos Reppas, Maria Vertzoni

AAPS J· November 2020

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