Publications by authors named "Karl J Mathis"

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MMP-13 selective α-sulfone hydroxamates: a survey of P1' heterocyclic amide isosteres.
Thomas E Barta, Daniel P Becker, Louis J Bedell, Alan M Easton, Susan L Hockerman, Karl J Mathis

Bioorg Med Chem Lett· May 2011

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Structure analysis reveals the flexibility of the ADAMTS-5 active site.
Huey-Sheng Shieh, Alfredo G Tomasselli, Karl J Mathis, Mark E Schnute, Scott S Woodard

Protein Sci· April 2011

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Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease.
Daniel P Becker, Thomas E Barta, Louis J Bedell, Terri L Boehm, Brian R Bond, Karl J Mathis

J Med Chem· September 2010

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Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode.
Marvin J Meyers, Matthew Pelc, Satwik Kamtekar, Jacqueline Day, Gennadiy I Poda, Karl J Mathis

Bioorg Med Chem Lett· March 2010

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Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors.
Micky D Tortorella, Alfredo G Tomasselli, Karl J Mathis, Mark E Schnute, Scott S Woodard

J Biol Chem· September 2009

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The titerless infected-cells preservation and scale-up (TIPS) method for large-scale production of NO-sensitive human soluble guanylate cyclase (sGC) from insect cells infected with recombinant baculovirus.
David J Wasilko, S Edward Lee, Kim J Stutzman-Engwall, Beverly A Reitz, Thomas L Emmons, Karl J Mathis

Protein Expr Purif· June 2009

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Purification and characterization of recombinant human soluble guanylate cyclase produced from baculovirus-infected insect cells.
Thomas L Emmons, Karl J Mathis, Mary E Shuck, Beverly A Reitz, Daniel F Curran

Protein Expr Purif· June 2009

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2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: design and synthesis of a potent and isoform selective PKC-zeta inhibitor.
John I Trujillo, James R Kiefer, Wei Huang, Atli Thorarensen, Li Xing, Karl J Mathis

Bioorg Med Chem Lett· February 2009

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High yield purification of soluble guanylate cyclase from bovine lung.
Karl J Mathis, Thomas L Emmons, Daniel F Curran, Jacqueline E Day, Alfredo G Tomasselli

Protein Expr Purif· July 2008

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High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2).
Huey-Sheng Shieh, Karl J Mathis, Jennifer M Williams, Robert L Hills, Joe F Wiese

J Biol Chem· January 2008

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Mammalian cell production and purification of progenipoietin, a dual-agonist chimaeric haematopoietic growth factor.
David C Wood, Karl J Mathis, William D Joy, John C Minnerly, Lyle E Pegg

Biotechnol Appl Biochem· February 2003

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Purification and characterization of progenipoietins produced in Escherichia. coli.
Bernard N Violand, John C Minnerly, Yiqing G Feng, Joseph O Polazzi, Karl J Mathis

Protein Expr Purif· November 2002

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