Publications by authors named "Karl Malcolm"

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Use of hydrophilic pharmaceutical excipients to modulate release of metal ions from silicone elastomers.
Xin Shen, Xinyu Zhao, Clare F McCoy, Yahya H Dallal Bashi, Peter Boyd, R Karl Malcolm

Drug Deliv· December 2025

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A prodrug strategy for sustained release of lactic acid from silicone elastomer vaginal rings.
Yahya H Dallal Bashi, Xinyu Zhao, Clare F McCoy, Narender Kumar, Natalia Teleshova, R Karl Malcolm

Int J Pharm· November 2025

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A multipurpose silicone elastomer vaginal ring releasing dapivirine and Cu/Zn ions for HIV prevention and non-hormonal contraception.
Xin Shen, Peter Boyd, Yahya H Dallal Bashi, Clare F McCoy, Xinyu Zhao, R Karl Malcolm

Int J Pharm· April 2025

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Editorial: Multipurpose prevention technologies for HIV, STIs and pregnancies.
Barbara A Friedland, Andrea Ries Thurman, Harriet Nuwagaba-Biribonwoha, R Karl Malcolm

Front Reprod Health· February 2024

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First-in-human study to assess the pharmacokinetics, tolerability, and safety of single-dose oxybutynin hydrochloride administered via a microprocessor-controlled intravaginal ring.
Willem de Laat, Lisa Pagan, R Karl Malcolm, Maarten Wiegerinck, Victor Nickolson

Drug Deliv· December 2023

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Two into one does go: Formulation development of a multipurpose combination vaginal ring releasing dapivirine and metronidazole for prevention of HIV infection and treatment of bacterial vaginosis.
Xinyu Zhao, Peter Boyd, Yahya Dallal Bashi, Diarmaid J Murphy, Clare F McCoy, R Karl Malcolm

Int J Pharm· December 2023

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Physicochemical considerations in the formulation development of silicone elastomer vaginal rings releasing 5-nitroimidazole drugs for the treatment of bacterial vaginosis.
Xinyu Zhao, Peter Boyd, Yahya H Dallal Bashi, Clare F McCoy, R Karl Malcolm

Int J Pharm· September 2023

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Refining the in vitro release test method for a dapivirine-releasing vaginal ring to match in vivo performance.
Diarmaid J Murphy, Deanna Lim, Ryan Armstrong, Clare F McCoy, Yahya H Dallal Bashi, R Karl Malcolm

Drug Deliv Transl Res· August 2023

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drug release, mechanical performance and stability testing of a custom silicone elastomer vaginal ring releasing dapivirine and levonorgestrel.
Diarmaid J Murphy, Yahya H Dallal Bashi, Clare F McCoy, Peter Boyd, Leeanne Brown, R Karl Malcolm

Int J Pharm X· December 2022

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Pharmacological Approaches for the Prevention of Breast Implant Capsular Contracture.
Eugénie Guimier, Louise Carson, Benny David, James M Lambert, Enda Heery, R Karl Malcolm

J Surg Res· December 2022

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Color, Scent and Size: Exploring Women's Preferences Around Design Characteristics of Drug-Releasing Vaginal Rings.
Xinyu Zhao, Cecilia Milford, Jenni Smit, Bongiwe Zulu, Peter Boyd, R Karl Malcolm

AIDS Behav· September 2022

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The pharmacology of HIV-1 antiretrovirals differs between macaques and humans.
Carolina Herrera, Mackenzie L Cottrell, John Prybylski, Angela D M Kashuba, Ronald S Veazey, Karl R Malcolm

iScience· June 2022

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Linking robust spatiotemporal datasets to assess and monitor habitat attributes of a threatened species.
Chris Witt, Raymond J Davis, Zhiqiang Yang, Joseph L Ganey, R J Gutiérrez, Karl Malcolm

PLoS One· May 2022

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Use of simulated vaginal and menstrual fluids to model discolouration of silicone elastomer vaginal rings.
Clare F McCoy, Patrick Spence, Yahya H Dallal Bashi, Diarmaid J Murphy, Peter Boyd, R Karl Malcolm

Int J Pharm X· December 2021

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Silicone elastomer formulations for improved performance of a multipurpose vaginal ring releasing dapivirine and levonorgestrel.
Yahya H Dallal Bashi, Diarmaid J Murphy, Clare F McCoy, Peter Boyd, Leeanne Brown, R Karl Malcolm

Int J Pharm X· December 2021

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Recent advances in electrospun nanofiber vaginal formulations for women's sexual and reproductive health.
Raúl Cazorla-Luna, Roberto Ruiz-Caro, María-Dolores Veiga, R Karl Malcolm, Dimitrios A Lamprou

Int J Pharm· September 2021

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The ins and outs of drug-releasing vaginal rings: a literature review of expulsions and removals.
Peter Boyd, Ruth Merkatz, Bruce Variano, R Karl Malcolm

Expert Opin Drug Deliv· November 2020

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Dapivirine-releasing vaginal rings produced by plastic freeforming additive manufacturing.
Nicole R Welsh, R Karl Malcolm, Brid Devlin, Peter Boyd

Int J Pharm· December 2019

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In vitro release testing methods for drug-releasing vaginal rings.
Peter Boyd, Bruce Variano, Patrick Spence, Clare F McCoy, Diarmaid J Murphy, R Karl Malcolm

J Control Release· November 2019

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Towards a dapivirine and levonorgestrel multipurpose vaginal ring: Investigations into the reaction between levonorgestrel and addition-cure silicone elastomers.
Yahya H Dallal Bashi, Clare F McCoy, Diarmaid J Murphy, Peter Boyd, Patrick Spence, R Karl Malcolm

Int J Pharm· October 2019

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Post-use ring weight and residual drug content as potential objective measures of user adherence to a contraceptive progesterone vaginal ring.
Diarmaid J Murphy, Clare F McCoy, Marlena Plagianos, Saumya RamaRao, Ruth Merkatz, R Karl Malcolm

Contraception· September 2019

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Development and pharmacokinetics of a combination vaginal ring for sustained release of dapivirine and the protein microbicide 5P12-RANTES.
John W McBride, R Karl Malcolm, Nicola Dias, David Cameron, Robin E Offord

Int J Pharm· June 2019

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Drug stability and product performance characteristics of a dapivirine-releasing vaginal ring under simulated real-world conditions.
Diarmaid J Murphy, Clare F McCoy, Peter Boyd, Tiffany Derrick, Patrick Spence, R Karl Malcolm

Int J Pharm· June 2019

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Mechanical testing methods for drug-releasing vaginal rings.
Clare F McCoy, Bronagh G Millar, Diarmaid J Murphy, Wendy Blanda, Bashir Hansraj, R Karl Malcolm

Int J Pharm· March 2019

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Vaginal rings with exposed cores for sustained delivery of the HIV CCR5 inhibitor 5P12-RANTES.
John W McBride, Peter Boyd, Nicola Dias, David Cameron, Robin E Offord, R Karl Malcolm

J Control Release· March 2019

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