Publications by authors named "Karl Staples"

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A novel SPECT-CT imaging platform for quantifying lung cytokine signals in COPD.
Benjamin Welham, Michael Bennett, Kristoffer Ostridge, Matthew Guy, Clint Zvavamwe, Karl J Staples

ERJ Open Res· November 2025

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The respiratory tract virome: unravelling the role of viral dark matter in respiratory health and disease.
Martha Purcell, Jodie Ackland, Karl J Staples, Anna Freeman, Tom M A Wilkinson

Eur Respir Rev· July 2025

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Influenza-induced microRNA-155 expression is altered in extracellular vesicles derived from the COPD epithelium.
Laura V Reid, C Mirella Spalluto, Tom M A Wilkinson, Karl J Staples

Front Cell Infect Microbiol· June 2025

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Understanding Infection, Viral Exacerbation and Respiratory Symptoms at Admission-Longitudinal (UNIVERSAL) study: a prospective observational cohort study protocol.
Tommaso Morelli, Martha Purcell, Pedro Rodrigues, Charles Roberts, Olivia Cox, Karl J Staples

BMJ Open· April 2025

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Natural killer cells in the lung: novel insight and future challenge in the airway diseases.
Tommaso Pianigiani, Irene Paggi, Grace E Cooper, Karl J Staples, Melissa McDonnell

ERJ Open Res· March 2025

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Lung IL-13 gene signatures are associated with raised tissue eosinophils in COPD.
Karl J Staples, Jodie Ackland, Sruthymol Lukose, Bastian Angermann, Graham Belfield

Respir Res· March 2025

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Hidden in plain sight: the impact of human rhinovirus infection in adults.
Tommaso Morelli, Anna Freeman, Karl J Staples, Tom M A Wilkinson

Respir Res· March 2025

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In Asthma, Change Is the Only Constant.
Karl J Staples

Am J Respir Crit Care Med· February 2025

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NTHi killing activity is reduced in COPD patients and is associated with a differential microbiome.
Vancheswaran Gopalakrishnan, Ben Sparklin, Jung Hwan Kim, Jerome Bouquet, Margaret Kehl, Karl J Staples

Respir Res· January 2025

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Mechanisms of SARS-CoV-2 Inactivation Using UVC Laser Radiation.
George Devitt, Peter B Johnson, Niall Hanrahan, Simon I R Lane, Magdalena C Vidale, Karl Staples

ACS Photonics· January 2024

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Multiomics links global surfactant dysregulation with airflow obstruction and emphysema in COPD.
Ventzislava A Hristova, Alastair Watson, Raghothama Chaerkady, Matthew S Glover, Jodie Ackland, Karl J Staples

ERJ Open Res· May 2023

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Antiviral Responses of Tissue-resident CD49a Lung Natural Killer Cells Are Dysregulated in Chronic Obstructive Pulmonary Disease.
Grace E Cooper, Jemma Mayall, Chantal Donovan, Tatt J Haw, Kurtis F Budden, Karl J Staples

Am J Respir Crit Care Med· March 2023

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Breaching the Defenses? Mucosal-associated Invariant T Cells, Smoking, and Chronic Obstructive Pulmonary Disease.
Karl J Staples

Am J Respir Cell Mol Biol· January 2023

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Towards an artificial human lung: modelling organ-like complexity to aid mechanistic understanding.
Maria Victoria Humbert, Cosma Mirella Spalluto, Joseph Bell, Cornelia Blume, Franco Conforti, Karl J Staples

Eur Respir J· December 2022

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Pulmonary EV miRNA profiles identify disease and distinct inflammatory endotypes in COPD.
Hannah Burke, Doriana Cellura, Anna Freeman, Alex Hicks, Kris Ostridge, Karl J Staples

Front Med (Lausanne)· December 2022

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Nontypeable Haemophilus influenzae infection of pulmonary macrophages drives neutrophilic inflammation in severe asthma.
Jodie Ackland, Clair Barber, Ashley Heinson, Adnan Azim, David W Cleary, Karl J Staples

Allergy· October 2022

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The Role of Extracellular Vesicles as a Shared Disease Mechanism Contributing to Multimorbidity in Patients With COPD.
Laura V Reid, C Mirella Spalluto, Alastair Watson, Karl J Staples, Tom M A Wilkinson

Front Immunol· February 2022

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Immunopeptidomic analysis of influenza A virus infected human tissues identifies internal proteins as a rich source of HLA ligands.
Ben Nicholas, Alistair Bailey, Karl J Staples, Tom Wilkinson, Tim Elliott

PLoS Pathog· January 2022

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Exercise Training Induces a Shift in Extracellular Redox Status with Alterations in the Pulmonary and Systemic Redox Landscape in Asthma.
Anna Freeman, Doriana Cellura, Magdalena Minnion, Bernadette O Fernandez, Cosma Mirella Spalluto, Karl J Staples

Antioxidants (Basel)· November 2021

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Dual RNASeq Reveals NTHi-Macrophage Transcriptomic Changes During Intracellular Persistence.
Jodie Ackland, Ashley I Heinson, David W Cleary, Myron Christodoulides, Tom M A Wilkinson, Karl J Staples

Front Cell Infect Microbiol· October 2021

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Interrupting the Conversation: Implications for Crosstalk Between Viral and Bacterial Infections in the Asthmatic Airway.
Jodie Ackland, Alastair Watson, Tom M A Wilkinson, Karl J Staples

Front Allergy· October 2021

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The Role of Non-Typeable Biofilms in Chronic Obstructive Pulmonary Disease.
Jake R Weeks, Karl J Staples, C Mirella Spalluto, Alastair Watson, Tom M A Wilkinson

Front Cell Infect Microbiol· August 2021

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Influence of Hypoxia on the Epithelial-Pathogen Interactions in the Lung: Implications for Respiratory Disease.
Lee K Page, Karl J Staples, C Mirella Spalluto, Alastair Watson, Tom M A Wilkinson

Front Immunol· May 2021

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Dysregulation of COVID-19 related gene expression in the COPD lung.
Alastair Watson, Lisa Öberg, Bastian Angermann, C Mirella Spalluto, Michael Hühn, Karl J Staples

Respir Res· May 2021

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