Publications by authors named "Katelyn Connelly"

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Large-scale multiomic analysis identifies non-coding somatic driver mutations and nominates as a driver gene for pancreatic ductal adenocarcinoma.
Jun Zhong, Aidan O'Brien, Minal B Patel, Daina Eiser, Michael Mobaraki, Katelyn E Connelly

Gut· October 2025

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A Common CTRB misfolding variant associated with pancreatic cancer risk causes ER stress and inflammation in mice.
Cristina Bodas, Irene Felipe, Brice Chanez, Miguel Lafarga, Evangelina Lopez de Maturana, Katelyn Connelly

Gut· August 2025

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Allelic effects on KLHL17 expression underlie a pancreatic cancer genome-wide association signal at chr1p36.33.
Katelyn E Connelly, Katherine Hullin, Ehssan Abdolalizadeh, Jun Zhong, Daina Eiser

Nat Commun· April 2025

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Allelic effects on expression likely mediated by JunB/D underlie a PDAC GWAS signal at chr1p36.33.
Katelyn E Connelly, Katherine Hullin, Ehssan Abdolalizadeh, Jun Zhong, Daina Eiser

medRxiv· September 2024

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Large-scale multi-omic analysis identifies noncoding somatic driver mutations and nominates as a driver gene for pancreatic ductal adenocarcinoma.
Jun Zhong, Aidan O'Brien, Minal Patel, Daina Eiser, Michael Mobaraki, Katelyn E Connelly

medRxiv· September 2024

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A common CTRB misfolding variant associated with pancreatic cancer risk causes ER stress and inflammation in mice.
Cristina Bodas, Irene Felipe, Brice Chanez, Miguel Lafarga, Evangelina López de Maturana, Katelyn E Connelly

bioRxiv· July 2024

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Inferred expression regulator activities suggest genes mediating cardiometabolic genetic signals.
Jason W Hoskins, Charles C Chung, Aidan O'Brien, Jun Zhong, Katelyn Connelly

PLoS Comput Biol· November 2021

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Polycomb Paralog Chromodomain Inhibitors Active against Both CBX6 and CBX8*.
Natalia Milosevich, Chelsea R Wilson, Tyler M Brown, Aktan Alpsoy, Sijie Wang, Katelyn E Connelly

ChemMedChem· October 2021

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A 584 bp deletion in CTRB2 inhibits chymotrypsin B2 activity and secretion and confers risk of pancreatic cancer.
Ashley Jermusyk, Jun Zhong, Katelyn E Connelly, Naomi Gordon, Sumeth Perera

Am J Hum Genet· October 2021

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Optimization of Ligands Using Focused DNA-Encoded Libraries To Develop a Selective, Cell-Permeable CBX8 Chromodomain Inhibitor.
Sijie Wang, Kyle E Denton, Kathryn F Hobbs, Tyler Weaver, James M B McFarlane, Katelyn E Connelly

ACS Chem Biol· January 2020

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Engagement of DNA and H3K27me3 by the CBX8 chromodomain drives chromatin association.
Katelyn E Connelly, Tyler M Weaver, Aktan Alpsoy, Brian X Gu, Catherine A Musselman

Nucleic Acids Res· March 2019

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The EZH2 SANT1 domain is a histone reader providing sensitivity to the modification state of the H4 tail.
Tyler M Weaver, Jiachen Liu, Katelyn E Connelly, Chris Coble, Katayoun Varzavand

Sci Rep· January 2019

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Analysis of Human Nuclear Protein Complexes by Quantitative Mass Spectrometry Profiling.
Katelyn E Connelly, Victoria Hedrick, Tiago Jose Paschoal Sobreira, Emily C Dykhuizen, Uma K Aryal

Proteomics· June 2018

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Sequential Salt Extractions for the Analysis of Bulk Chromatin Binding Properties of Chromatin Modifying Complexes.
Elizabeth G Porter, Katelyn E Connelly, Emily C Dykhuizen

J Vis Exp· October 2017

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Compositional and functional diversity of canonical PRC1 complexes in mammals.
Katelyn E Connelly, Emily C Dykhuizen

Biochim Biophys Acta Gene Regul Mech· February 2017

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CBX Chromodomain Inhibition Enhances Chemotherapy Response in Glioblastoma Multiforme.
Katelyn E Connelly, Emily C Martin, Emily C Dykhuizen

Yale J Biol Med· December 2016

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