Publications by authors named "Katrin Rittinger"

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Conformational dynamics of the bacterial E3 ligase SspH1.
Cassandra R Kennedy, Diego Esposito, Jessica Huber, David House, Katrin Rittinger

J Biol Chem· October 2025

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Covalent fragment screening to inhibit the E3 ligase activity of bacterial NEL enzymes SspH1 and SspH2.
Cassandra R Kennedy, Katherine A McPhie, Aini Vuorinen, Jane Dudley-Fraser, Diego Esposito, Katrin Rittinger

RSC Chem Biol· October 2025

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Bacterial effectors mediate kinase reprogramming through mimicry of conserved eukaryotic motifs.
Ioanna Panagi, Janina H Muench, Alexi Ronneau, Ines Diaz-Del-Olmo, Agnel Aliyath, Katrin Rittinger

EMBO Rep· July 2025

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Discovery and optimisation of a covalent ligand for TRIM25 and its application to targeted protein ubiquitination.
Katherine A McPhie, Diego Esposito, Jonathan Pettinger, Daniel Norman, Thilo Werner, Katrin Rittinger

Chem Sci· June 2025

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Identification of RING E3 pseudoligases in the TRIM protein family.
Jane Dudley-Fraser, Diego Esposito, Katherine A McPhie, Coltrane Morley-Williams, Tania Auchynnikava, Katrin Rittinger

Nat Commun· April 2025

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Robust proteome profiling of cysteine-reactive fragments using label-free chemoproteomics.
George S Biggs, Emma E Cawood, Aini Vuorinen, William J McCarthy, Harry Wilders, Katrin Rittinger

Nat Commun· January 2025

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Enantioselective OTUD7B fragment discovery through chemoproteomics screening and high-throughput optimisation.
Aini Vuorinen, Cassandra R Kennedy, Katherine A McPhie, William McCarthy, Jonathan Pettinger, Katrin Rittinger

Commun Chem· January 2025

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The molecular dissection of TRIM25's RNA-binding mechanism provides key insights into its antiviral activity.
Lucía Álvarez, Kevin Haubrich, Louisa Iselin, Laurent Gillioz, Vincenzo Ruscica, Katrin Rittinger

Nat Commun· October 2024

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Covalent fragment-based drug discovery for target tractability.
William J McCarthy, Antonie J van der Zouwen, Jacob T Bush, Katrin Rittinger

Curr Opin Struct Biol· June 2024

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It's a TRIM-endous view from the top: the varied roles of TRIpartite Motif proteins in brain development and disease.
Jane Dudley-Fraser, Katrin Rittinger

Front Mol Neurosci· December 2023

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Efficient Ligand Discovery Using Sulfur(VI) Fluoride Reactive Fragments.
Arron Aatkar, Aini Vuorinen, Oliver E Longfield, Katharine Gilbert, Rachel Peltier-Heap, Katrin Rittinger

ACS Chem Biol· September 2023

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Profiling Sulfur(VI) Fluorides as Reactive Functionalities for Chemical Biology Tools and Expansion of the Ligandable Proteome.
Katharine E Gilbert, Aini Vuorinen, Arron Aatkar, Peter Pogány, Jonathan Pettinger, Katrin Rittinger

ACS Chem Biol· February 2023

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Structural basis for ubiquitylation by HOIL-1.
Qilong Wu, Marios G Koliopoulos, Katrin Rittinger, Benjamin Stieglitz

Front Mol Biosci· January 2023

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Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity.
Diego Esposito, Jane Dudley-Fraser, Acely Garza-Garcia, Katrin Rittinger

Nat Commun· December 2022

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Characterisation of HOIP RBR E3 ligase conformational dynamics using integrative modelling.
Marius Kausas, Diego Esposito, Katrin Rittinger, Franca Fraternali

Sci Rep· September 2022

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Targeting the ubiquitin system by fragment-based drug discovery.
Cassandra Kennedy, Katherine McPhie, Katrin Rittinger

Front Mol Biosci· September 2022

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Does it take two to tango? RING domain self-association and activity in TRIM E3 ubiquitin ligases.
Filippo Fiorentini, Diego Esposito, Katrin Rittinger

Biochem Soc Trans· December 2020

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Advanced rules of relays.
Sonja Lorenz, Katrin Rittinger

Nat Chem Biol· November 2020

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The product PACRG promotes TNF signaling by stabilizing LUBAC.
Jens Meschede, Maria Šadić, Nikolas Furthmann, Tim Miedema, Dominik A Sehr, Katrin Rittinger

Sci Signal· February 2020

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Single-Domain Antibodies as Crystallization Chaperones to Enable Structure-Based Inhibitor Development for RBR E3 Ubiquitin Ligases.
Yi-Chun Isabella Tsai, Henrik Johansson, David Dixon, Stephen Martin, Chun-Wa Chung, Katrin Rittinger

Cell Chem Biol· January 2020

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Characterisation of class VI TRIM RING domains: linking RING activity to C-terminal domain identity.
Rebecca V Stevens, Diego Esposito, Katrin Rittinger

Life Sci Alliance· June 2019

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Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP.
Henrik Johansson, Yi-Chun Isabella Tsai, Ken Fantom, Chun-Wa Chung, Sandra Kümper, Katrin Rittinger

J Am Chem Soc· February 2019

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Structure-function analyses of the bacterial zinc metalloprotease effector protein GtgA uncover key residues required for deactivating NF-κB.
Elliott Jennings, Diego Esposito, Katrin Rittinger, Teresa L M Thurston

J Biol Chem· September 2018

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RBR ligase-mediated ubiquitin transfer: a tale with many twists and turns.
Helen Walden, Katrin Rittinger

Nat Struct Mol Biol· June 2018

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Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition.
Marios G Koliopoulos, Mathilde Lethier, Annemarthe G van der Veen, Kevin Haubrich, Janosch Hennig, Katrin Rittinger

Nat Commun· May 2018

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