Publications by authors named "Jacob T Bush"

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Discovery and optimisation of a covalent ligand for TRIM25 and its application to targeted protein ubiquitination.
Katherine A McPhie, Diego Esposito, Jonathan Pettinger, Daniel Norman, Thilo Werner, Jacob T Bush

Chem Sci· June 2025

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Expedited SARS-CoV-2 Main Protease Inhibitor Discovery through Modular 'Direct-to-Biology' Screening.
Harry Wilders, George Biggs, Sam M Rowe, Emma E Cawood, Ioannis G Riziotis, Jacob T Bush

Angew Chem Int Ed Engl· February 2025

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Robust proteome profiling of cysteine-reactive fragments using label-free chemoproteomics.
George S Biggs, Emma E Cawood, Aini Vuorinen, William J McCarthy, Harry Wilders, Jacob T Bush

Nat Commun· January 2025

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Enantioselective OTUD7B fragment discovery through chemoproteomics screening and high-throughput optimisation.
Aini Vuorinen, Cassandra R Kennedy, Katherine A McPhie, William McCarthy, Jonathan Pettinger, Jacob T Bush

Commun Chem· January 2025

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mRNA Display in Cell Lysates Enables Identification of Cyclic Peptides Targeting the BRD3 Extraterminal Domain.
Catherine A Hurd, Jacob T Bush, Andrew J Powell, Louise J Walport

Angew Chem Int Ed Engl· September 2024

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Mapping protein binding sites by photoreactive fragment pharmacophores.
Péter Ábrányi-Balogh, Dávid Bajusz, Zoltán Orgován, Aaron B Keeley, László Petri, Jacob T Bush

Commun Chem· July 2024

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Covalent fragment-based drug discovery for target tractability.
William J McCarthy, Antonie J van der Zouwen, Jacob T Bush, Katrin Rittinger

Curr Opin Struct Biol· June 2024

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Mutate and Conjugate: A Method to Enable Rapid In-Cell Target Validation.
Adam M Thomas, Marta Serafini, Emma K Grant, Edward A J Coombs, Joseph P Bluck, Jacob T Bush

ACS Chem Biol· November 2023

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Efficient Ligand Discovery Using Sulfur(VI) Fluoride Reactive Fragments.
Arron Aatkar, Aini Vuorinen, Oliver E Longfield, Katharine Gilbert, Rachel Peltier-Heap, Jacob T Bush

ACS Chem Biol· September 2023

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Photoaffinity labelling displacement assay using multiple recombinant protein domains.
David J Fallon, Alex Phillipou, Christopher J Schofield, David House, Nicholas C O Tomkinson, Jacob T Bush

Biochem J· August 2023

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Reactive fragments targeting carboxylate residues employing direct to biology, high-throughput chemistry.
Ross P Thomas, Emma K Grant, Eleanor R Dickinson, Francesca Zappacosta, Lee J Edwards, Jacob T Bush

RSC Med Chem· April 2023

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Profiling Sulfur(VI) Fluorides as Reactive Functionalities for Chemical Biology Tools and Expansion of the Ligandable Proteome.
Katharine E Gilbert, Aini Vuorinen, Arron Aatkar, Peter Pogány, Jonathan Pettinger, Jacob T Bush

ACS Chem Biol· February 2023

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A Chemo- and Regioselective Tandem [3 + 2]Heteroannulation Strategy for Carbazole Synthesis: Combining Two Mechanistically Distinct Bond-Forming Processes.
Emma Campbell, Andrea Taladriz-Sender, Olivia I Paisley, Alan R Kennedy, Jacob T Bush

J Org Chem· April 2022

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One-Step Synthesis of Photoaffinity Probes for Live-Cell MS-Based Proteomics.
David J Fallon, Stephanie Lehmann, Chun-Wa Chung, Alex Phillipou, Christian Eberl, Jacob T Bush

Chemistry· December 2021

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Optimization of Metabolic Oligosaccharide Engineering with AcGalNAlk and AcGlcNAlk by an Engineered Pyrophosphorylase.
Anna Cioce, Ganka Bineva-Todd, Anthony J Agbay, Junwon Choi, Thomas M Wood, Jacob T Bush

ACS Chem Biol· October 2021

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A direct-to-biology high-throughput chemistry approach to reactive fragment screening.
Ross P Thomas, Rachel E Heap, Francesca Zappacosta, Emma K Grant, Peter Pogány, Jacob T Bush

Chem Sci· September 2021

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A Photoaffinity-Based Fragment-Screening Platform for Efficient Identification of Protein Ligands.
Emma K Grant, David J Fallon, Michael M Hann, Ken G M Fantom, Chad Quinn, Jacob T Bush

Angew Chem Int Ed Engl· November 2020

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A Turing Test for Molecular Generators.
Jacob T Bush, Peter Pogany, Stephen D Pickett, Mike Barker, Andrew Baxter

J Med Chem· October 2020

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Quantitative MS-Based Proteomics: Comparing the MCF-7 Cellular Response to Hypoxia and a 2-Oxoglutarate Analogue.
Jacob T Bush, Mun Chiang Chan, Shabaz Mohammed, Christopher J Schofield

Chembiochem· June 2020

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A Photoaffinity Displacement Assay and Probes to Study the Cyclin-Dependent Kinase Family.
Emma K Grant, David J Fallon, H Christian Eberl, Ken G M Fantom, Francesca Zappacosta, Jacob T Bush

Angew Chem Int Ed Engl· November 2019

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Small-molecules that covalently react with a human prolyl hydroxylase - towards activity modulation and substrate capture.
Jacob T Bush, Robert K Leśniak, Tzu-Lan Yeh, Roman Belle, Holger Kramer

Chem Commun (Camb)· January 2019

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Selectively Targeting the Kinome-Conserved Lysine of PI3Kδ as a General Approach to Covalent Kinase Inhibition.
Samuel E Dalton, Lars Dittus, Daniel A Thomas, Máire A Convery, Joao Nunes, Jacob T Bush

J Am Chem Soc· January 2018

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Systematic review of clinical trials assessing the therapeutic efficacy of visceral leishmaniasis treatments: A first step to assess the feasibility of establishing an individual patient data sharing platform.
Jacob T Bush, Monique Wasunna, Fabiana Alves, Jorge Alvar, Piero L Olliaro

PLoS Negl Trop Dis· September 2017

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Studies on deacetoxycephalosporin C synthase support a consensus mechanism for 2-oxoglutarate dependent oxygenases.
Hanna Tarhonskaya, Andrea Szöllössi, Ivanhoe K H Leung, Jacob T Bush, Luc Henry

Biochemistry· April 2014

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A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1.
Rachel Schiller, Giuseppe Scozzafava, Anthony Tumber, James R Wickens, Jacob T Bush

ChemMedChem· March 2014

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